Tags

Type your tag names separated by a space and hit enter

Regulation of the expression of the serine dehydratase gene in the kidney and liver of the rat.
Biochem Biophys Res Commun. 1990 Jul 31; 170(2):892-9.BB

Abstract

Serine dehydratase was induced in the kidneys of normal rats by the administration of either glucagon or dexamethasone. The increase in enzyme activity was associated with an increase in both enzyme protein and its mRNA, which were determined respectively by Western blot and RNA blot analysis. No apparent differences were observed between kidney and liver in the molecular weights of serine dehydratase proteins and the sizes of their mRNAs. Although kidney serine dehydratase was dramatically induced by either glucagon or dexamethasone, the liver enzyme was induced by glucagon but not by dexamethasone alone in the intact rat. On the other hand, liver serine dehydratase was induced in starvation, diabetes mellitus, and a high-protein diet. The kidney enzyme could not be induced under any of these conditions.

Authors+Show Affiliations

Su Y
McArdle Laboratory for Cancer Research, Medical School, University of Wisconsin, Madison 53706.
Kanamoto R
No affiliation info available
Miller DA
No affiliation info available
Ogawa H
No affiliation info available
Pitot HC
No affiliation info available

MeSH

AnimalsBlotting, WesternDexamethasoneDiabetes Mellitus, ExperimentalEnzyme InductionGene Expression Regulation, EnzymologicGlucagonKidneyL-Serine DehydrataseLiverMaleRNA, MessengerRatsRats, Inbred Strains

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2383271

Citation

Su, Y, et al. "Regulation of the Expression of the Serine Dehydratase Gene in the Kidney and Liver of the Rat." Biochemical and Biophysical Research Communications, vol. 170, no. 2, 1990, pp. 892-9.
Su Y, Kanamoto R, Miller DA, et al. Regulation of the expression of the serine dehydratase gene in the kidney and liver of the rat. Biochem Biophys Res Commun. 1990;170(2):892-9.
Su, Y., Kanamoto, R., Miller, D. A., Ogawa, H., & Pitot, H. C. (1990). Regulation of the expression of the serine dehydratase gene in the kidney and liver of the rat. Biochemical and Biophysical Research Communications, 170(2), 892-9.
Su Y, et al. Regulation of the Expression of the Serine Dehydratase Gene in the Kidney and Liver of the Rat. Biochem Biophys Res Commun. 1990 Jul 31;170(2):892-9. PubMed PMID: 2383271.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regulation of the expression of the serine dehydratase gene in the kidney and liver of the rat. AU - Su,Y, AU - Kanamoto,R, AU - Miller,D A, AU - Ogawa,H, AU - Pitot,H C, PY - 1990/7/31/pubmed PY - 1990/7/31/medline PY - 1990/7/31/entrez SP - 892 EP - 9 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 170 IS - 2 N2 - Serine dehydratase was induced in the kidneys of normal rats by the administration of either glucagon or dexamethasone. The increase in enzyme activity was associated with an increase in both enzyme protein and its mRNA, which were determined respectively by Western blot and RNA blot analysis. No apparent differences were observed between kidney and liver in the molecular weights of serine dehydratase proteins and the sizes of their mRNAs. Although kidney serine dehydratase was dramatically induced by either glucagon or dexamethasone, the liver enzyme was induced by glucagon but not by dexamethasone alone in the intact rat. On the other hand, liver serine dehydratase was induced in starvation, diabetes mellitus, and a high-protein diet. The kidney enzyme could not be induced under any of these conditions. SN - 0006-291X UR - https://www.unboundmedicine.com/medline/citation/2383271/Regulation_of_the_expression_of_the_serine_dehydratase_gene_in_the_kidney_and_liver_of_the_rat_ DB - PRIME DP - Unbound Medicine ER -