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[The clinical studies of hyperhomocysteinemia and Alzheimer's disease].
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2013 Mar; 29(2):116-8, 127.ZY

Abstract

OBJECTIVE

To observe the correlation between the decline of cognitive function and the level of plasma homocysteine in patients with Alzheimer's disease (AD).

METHODS

Thirty six AD patients were selected from hospitals in Tianjin. The enrolled patients were in accord with the diagnosis criteria. Thirty two control subjects were corresponding patients without AD in the period. Blood samples were extracted from each subject to determine the levels of homocysteine (Hcy) and folate. Cognitive status was evaluated by the mini- mental state examination (MMSE) and clinical dementia rating scale (CDR).

RESULTS

The mean value of serum Hcy concentration [(17.51 +/- 5.62) micromol/L] of AD group was higher than that of control group [(12.38 +/- 4.25)micromol/L]. The serum [(5.17 +/- 1.76) microg/L] and diet folate [(206.94 +/- 44.51) microg/d] concentration of AD group were lower than those of control group [(7.92 +/- 2.22) microg/L, (259.74 +/- 41.92) microg/ d]. The incidence of hyperhomocysteinemia in AD group (64%) was higher than that in control group (22%). A significant relation between Hcy concentrations and the CDR was observed. With the increase of Hcy concentrations the CDR raised, and with the increase of Hcy concentrations the MMSE decreased.

CONCLUSION

Hyperhomocysteinemia is one of the risk factors inducing the onset of AD. There is a significant negative correlation between Hcy levels and cognitive levels in AD group. Folate deficiency is an important reason to cause elevated Hcy levels in AD.

Authors+Show Affiliations

The First Affiliated Hospital of the University of Traditional Chinese Medicine, Tianjin 300193, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

23833960

Citation

Li, Yan-Ling, et al. "[The Clinical Studies of Hyperhomocysteinemia and Alzheimer's Disease]." Zhongguo Ying Yong Sheng Li Xue Za Zhi = Zhongguo Yingyong Shenglixue Zazhi = Chinese Journal of Applied Physiology, vol. 29, no. 2, 2013, pp. 116-8, 127.
Li YL, Hou Y, Niu C, et al. [The clinical studies of hyperhomocysteinemia and Alzheimer's disease]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2013;29(2):116-8, 127.
Li, Y. L., Hou, Y., Niu, C., Yu, L. X., Cheng, Y. Y., & Hong, Y. (2013). [The clinical studies of hyperhomocysteinemia and Alzheimer's disease]. Zhongguo Ying Yong Sheng Li Xue Za Zhi = Zhongguo Yingyong Shenglixue Zazhi = Chinese Journal of Applied Physiology, 29(2), 116-8, 127.
Li YL, et al. [The Clinical Studies of Hyperhomocysteinemia and Alzheimer's Disease]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2013;29(2):116-8, 127. PubMed PMID: 23833960.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The clinical studies of hyperhomocysteinemia and Alzheimer's disease]. AU - Li,Yan-Ling, AU - Hou,Yue, AU - Niu,Chao, AU - Yu,Li-Xia, AU - Cheng,Yi-Yong, AU - Hong,Yan, PY - 2013/7/10/entrez PY - 2013/7/10/pubmed PY - 2014/1/24/medline SP - 116-8, 127 JF - Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology JO - Zhongguo Ying Yong Sheng Li Xue Za Zhi VL - 29 IS - 2 N2 - OBJECTIVE: To observe the correlation between the decline of cognitive function and the level of plasma homocysteine in patients with Alzheimer's disease (AD). METHODS: Thirty six AD patients were selected from hospitals in Tianjin. The enrolled patients were in accord with the diagnosis criteria. Thirty two control subjects were corresponding patients without AD in the period. Blood samples were extracted from each subject to determine the levels of homocysteine (Hcy) and folate. Cognitive status was evaluated by the mini- mental state examination (MMSE) and clinical dementia rating scale (CDR). RESULTS: The mean value of serum Hcy concentration [(17.51 +/- 5.62) micromol/L] of AD group was higher than that of control group [(12.38 +/- 4.25)micromol/L]. The serum [(5.17 +/- 1.76) microg/L] and diet folate [(206.94 +/- 44.51) microg/d] concentration of AD group were lower than those of control group [(7.92 +/- 2.22) microg/L, (259.74 +/- 41.92) microg/ d]. The incidence of hyperhomocysteinemia in AD group (64%) was higher than that in control group (22%). A significant relation between Hcy concentrations and the CDR was observed. With the increase of Hcy concentrations the CDR raised, and with the increase of Hcy concentrations the MMSE decreased. CONCLUSION: Hyperhomocysteinemia is one of the risk factors inducing the onset of AD. There is a significant negative correlation between Hcy levels and cognitive levels in AD group. Folate deficiency is an important reason to cause elevated Hcy levels in AD. SN - 1000-6834 UR - https://www.unboundmedicine.com/medline/citation/23833960/[The_clinical_studies_of_hyperhomocysteinemia_and_Alzheimer's_disease]_ L2 - https://medlineplus.gov/alzheimersdisease.html DB - PRIME DP - Unbound Medicine ER -
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