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Neurometabolic and microstructural alterations following a sports-related concussion in female athletes.
Brain Inj. 2013; 27(9):1038-46.BI

Abstract

BACKGROUND

Sports-related concussions are a major public health concern affecting millions of individuals annually. Neurometabolic and microstructural alterations have been reported in the chronic phase following a concussion in male athletes, while no study has investigated these alterations in female athletes.

METHODS

Neurometabolic and microstructural alterations following a concussion were investigated by comparing 10 female athletes with a concussion and 10 control female athletes, using magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI). Athletes with concussion were scanned at least 7 months post-concussion (mean = 18.9 months).

RESULTS

MRS revealed a significant lower level of myo-inositol in the hippocampus and the primary motor cortices (M1) bilaterally. DTI analysis using Tract-Based Spatial Statistics (TBSS) showed no difference in fractional anisotropy (FA) while higher level of mean diffusivity (MD) in athletes with concussion was detected in large white matter tracts including the forceps minors, inferior/superior longitudinal fasciculi, inferior fronto-occipital fasciculus, cingulum, uncinate fasciculus, anterior thalamic radiations and corticospinal tract. Moreover, a region of interest approach for the corpus callosum revealed a significant lower level of FA in the segment containing fibres projecting to M1.

CONCLUSIONS

This study demonstrates persistent neurometabolic and microstructural alterations in female athletes suffering a sports-related concussion.

Authors+Show Affiliations

Centre de Recherche en Neuropsychologie et Cognition, Department of Psychology, University of Montreal, Montréal, Québec, Canada. emilie.chamard@umontreal.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23834633

Citation

Chamard, Emilie, et al. "Neurometabolic and Microstructural Alterations Following a Sports-related Concussion in Female Athletes." Brain Injury, vol. 27, no. 9, 2013, pp. 1038-46.
Chamard E, Lassonde M, Henry L, et al. Neurometabolic and microstructural alterations following a sports-related concussion in female athletes. Brain Inj. 2013;27(9):1038-46.
Chamard, E., Lassonde, M., Henry, L., Tremblay, J., Boulanger, Y., De Beaumont, L., & Théoret, H. (2013). Neurometabolic and microstructural alterations following a sports-related concussion in female athletes. Brain Injury, 27(9), 1038-46. https://doi.org/10.3109/02699052.2013.794968
Chamard E, et al. Neurometabolic and Microstructural Alterations Following a Sports-related Concussion in Female Athletes. Brain Inj. 2013;27(9):1038-46. PubMed PMID: 23834633.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurometabolic and microstructural alterations following a sports-related concussion in female athletes. AU - Chamard,Emilie, AU - Lassonde,Maryse, AU - Henry,Luke, AU - Tremblay,Julie, AU - Boulanger,Yvan, AU - De Beaumont,Louis, AU - Théoret,Hugo, PY - 2013/7/10/entrez PY - 2013/7/10/pubmed PY - 2014/3/7/medline SP - 1038 EP - 46 JF - Brain injury JO - Brain Inj VL - 27 IS - 9 N2 - BACKGROUND: Sports-related concussions are a major public health concern affecting millions of individuals annually. Neurometabolic and microstructural alterations have been reported in the chronic phase following a concussion in male athletes, while no study has investigated these alterations in female athletes. METHODS: Neurometabolic and microstructural alterations following a concussion were investigated by comparing 10 female athletes with a concussion and 10 control female athletes, using magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI). Athletes with concussion were scanned at least 7 months post-concussion (mean = 18.9 months). RESULTS: MRS revealed a significant lower level of myo-inositol in the hippocampus and the primary motor cortices (M1) bilaterally. DTI analysis using Tract-Based Spatial Statistics (TBSS) showed no difference in fractional anisotropy (FA) while higher level of mean diffusivity (MD) in athletes with concussion was detected in large white matter tracts including the forceps minors, inferior/superior longitudinal fasciculi, inferior fronto-occipital fasciculus, cingulum, uncinate fasciculus, anterior thalamic radiations and corticospinal tract. Moreover, a region of interest approach for the corpus callosum revealed a significant lower level of FA in the segment containing fibres projecting to M1. CONCLUSIONS: This study demonstrates persistent neurometabolic and microstructural alterations in female athletes suffering a sports-related concussion. SN - 1362-301X UR - https://www.unboundmedicine.com/medline/citation/23834633/Neurometabolic_and_microstructural_alterations_following_a_sports_related_concussion_in_female_athletes_ L2 - https://www.tandfonline.com/doi/full/10.3109/02699052.2013.794968 DB - PRIME DP - Unbound Medicine ER -