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Persistence of yellow fever vaccine-induced antibodies after solid organ transplantation.
Am J Transplant. 2013 Sep; 13(9):2458-61.AJ

Abstract

Immunization using live attenuated vaccines represents a contra-indication after solid organ transplantation (SOT): consequently, transplant candidates planning to travel in countries where yellow fever is endemic should be vaccinated prior to transplantation. The persistence of yellow fever vaccine-induced antibodies after transplantation has not been studied yet. We measured yellow-fever neutralizing antibodies in 53 SOT recipients vaccinated prior to transplantation (including 29 kidney recipients and 18 liver recipients). All but one (98%) had protective titers of antibodies after a median duration of 3 years (min.: 0.8, max.: 21) after transplantation. The median antibody level was 40 U/L (interquartile range: 40-80). For the 46 patients with a known or estimated date of vaccination, yellow-fever antibodies were still detectable after a median time of 13 years (range: 2-32 years) post-immunization. Our data suggest there is long-term persistence of antibodies to yellow fever in SOT recipients who have been vaccinated prior to transplantation.

Authors+Show Affiliations

Assistance publique-hôpitaux de Paris, CHU Bicêtre, Service de maladies infectieuses et tropicales, Centre de vaccinations internationales, Paris, Le Kremlin-Bicêtre, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23834702

Citation

Wyplosz, B, et al. "Persistence of Yellow Fever Vaccine-induced Antibodies After Solid Organ Transplantation." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons, vol. 13, no. 9, 2013, pp. 2458-61.
Wyplosz B, Burdet C, François H, et al. Persistence of yellow fever vaccine-induced antibodies after solid organ transplantation. Am J Transplant. 2013;13(9):2458-61.
Wyplosz, B., Burdet, C., François, H., Durrbach, A., Duclos-Vallée, J. C., Mamzer-Bruneel, M. F., Poujol, P., Launay, O., Samuel, D., Vittecoq, D., & Consigny, P. H. (2013). Persistence of yellow fever vaccine-induced antibodies after solid organ transplantation. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 13(9), 2458-61. https://doi.org/10.1111/ajt.12338
Wyplosz B, et al. Persistence of Yellow Fever Vaccine-induced Antibodies After Solid Organ Transplantation. Am J Transplant. 2013;13(9):2458-61. PubMed PMID: 23834702.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Persistence of yellow fever vaccine-induced antibodies after solid organ transplantation. AU - Wyplosz,B, AU - Burdet,C, AU - François,H, AU - Durrbach,A, AU - Duclos-Vallée,J C, AU - Mamzer-Bruneel,M-F, AU - Poujol,P, AU - Launay,O, AU - Samuel,D, AU - Vittecoq,D, AU - Consigny,P H, AU - ,, Y1 - 2013/07/08/ PY - 2013/03/20/received PY - 2013/05/06/revised PY - 2013/05/13/accepted PY - 2013/7/10/entrez PY - 2013/7/10/pubmed PY - 2014/4/15/medline KW - Antibody persistence KW - immunization KW - solid organ transplantation KW - yellow-fever vaccine SP - 2458 EP - 61 JF - American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons JO - Am. J. Transplant. VL - 13 IS - 9 N2 - Immunization using live attenuated vaccines represents a contra-indication after solid organ transplantation (SOT): consequently, transplant candidates planning to travel in countries where yellow fever is endemic should be vaccinated prior to transplantation. The persistence of yellow fever vaccine-induced antibodies after transplantation has not been studied yet. We measured yellow-fever neutralizing antibodies in 53 SOT recipients vaccinated prior to transplantation (including 29 kidney recipients and 18 liver recipients). All but one (98%) had protective titers of antibodies after a median duration of 3 years (min.: 0.8, max.: 21) after transplantation. The median antibody level was 40 U/L (interquartile range: 40-80). For the 46 patients with a known or estimated date of vaccination, yellow-fever antibodies were still detectable after a median time of 13 years (range: 2-32 years) post-immunization. Our data suggest there is long-term persistence of antibodies to yellow fever in SOT recipients who have been vaccinated prior to transplantation. SN - 1600-6143 UR - https://www.unboundmedicine.com/medline/citation/23834702/full_citation L2 - https://doi.org/10.1111/ajt.12338 DB - PRIME DP - Unbound Medicine ER -