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The influence of waist circumference on insulin resistance and nonalcoholic fatty liver disease in apparently healthy Korean adults.
Clin Mol Hepatol. 2013 Jun; 19(2):140-7.CM

Abstract

BACKGROUND/AIMS

Waist circumference (WC) is a risk factor for metabolic syndrome and is related to insulin resistance (IR) and nonalcoholic fatty liver disease (NAFLD). The purpose of this study was to determine the association between WC and IR and NAFLD in apparently healthy Korean adults.

METHODS

The volunteers included in this cross-sectional study comprised 9,159 adults (5,052 men, 4,107 women) who participated in a comprehensive health checkup program. IR was evaluated by the homeostasis model assessment of IR (HOMA-IR) and was considered to be present when the HOMA-IR score was >2. NAFLD was evaluated by ultrasound examination. Elevated alanine aminotransferase (ALT) was defined as >40 IU/L in men and >35 IU/L in women. Logistic regression was performed to determine the odds ratios (ORs) and 95% confidence intervals (95% CIs) for NAFLD, IR, and ALT according to categorized levels of WC.

RESULTS

NAFLD was found in 2,553 (27.9%) of the participants (82.6% men, 17.4% women), while IR and elevated ALT were found in 17.2% (68.1% men, 31.9% women) and 10% (83% men, 17% women), respectively. After adjusting for confounding factors, the prevalence of NAFLD, IR, and elevated ALT was significantly associated with increases in WC quartile: highest quartile for NAFLD in men, OR=15.539, 95% CI=12.687-19.033; highest quartile for NAFLD in women, OR=48.732, 95% CI=23.918-99.288 (P<0.001); and highest quartile for IR in men, OR=17.576, 95% CI=13.283-23.255; highest quartile for IR in women, OR=11.078, 95% CI=7.813-15.708 (P<0.001); highest quartile for elevated ALT in men, OR=7.952, 95% CI=6.046-10.459; and highest quartile for elevated ALT in women, OR=8.487, 95% CI=4.679-15.395 (P<0.001).

CONCLUSIONS

WC contributes to IR and NAFLD in apparently healthy Korean adults, and thus may be an important factor in the development of IR and NAFLD.

Authors+Show Affiliations

Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23837138

Citation

Ju, Deok Yun, et al. "The Influence of Waist Circumference On Insulin Resistance and Nonalcoholic Fatty Liver Disease in Apparently Healthy Korean Adults." Clinical and Molecular Hepatology, vol. 19, no. 2, 2013, pp. 140-7.
Ju DY, Choe YG, Cho YK, et al. The influence of waist circumference on insulin resistance and nonalcoholic fatty liver disease in apparently healthy Korean adults. Clin Mol Hepatol. 2013;19(2):140-7.
Ju, D. Y., Choe, Y. G., Cho, Y. K., Shin, D. S., Yoo, S. H., Yim, S. H., Lee, J. Y., Park, J. H., Kim, H. J., Park, D. I., Sohn, C. I., Jeon, W. K., & Kim, B. I. (2013). The influence of waist circumference on insulin resistance and nonalcoholic fatty liver disease in apparently healthy Korean adults. Clinical and Molecular Hepatology, 19(2), 140-7. https://doi.org/10.3350/cmh.2013.19.2.140
Ju DY, et al. The Influence of Waist Circumference On Insulin Resistance and Nonalcoholic Fatty Liver Disease in Apparently Healthy Korean Adults. Clin Mol Hepatol. 2013;19(2):140-7. PubMed PMID: 23837138.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The influence of waist circumference on insulin resistance and nonalcoholic fatty liver disease in apparently healthy Korean adults. AU - Ju,Deok Yun, AU - Choe,Young Gil, AU - Cho,Yong Kyun, AU - Shin,Dong Suk, AU - Yoo,Su Hyeon, AU - Yim,Seo Hyoung, AU - Lee,Ji Yong, AU - Park,Jung Ho, AU - Kim,Hong Joo, AU - Park,Dong Il, AU - Sohn,Chong Il, AU - Jeon,Woo Kyu, AU - Kim,Byung Ik, Y1 - 2013/06/27/ PY - 2013/02/13/received PY - 2013/04/21/revised PY - 2013/05/07/accepted PY - 2013/7/10/entrez PY - 2013/7/10/pubmed PY - 2014/1/24/medline KW - Insulin resistance KW - Nonalcoholic fatty liver disease KW - Waist circumference SP - 140 EP - 7 JF - Clinical and molecular hepatology JO - Clin Mol Hepatol VL - 19 IS - 2 N2 - BACKGROUND/AIMS: Waist circumference (WC) is a risk factor for metabolic syndrome and is related to insulin resistance (IR) and nonalcoholic fatty liver disease (NAFLD). The purpose of this study was to determine the association between WC and IR and NAFLD in apparently healthy Korean adults. METHODS: The volunteers included in this cross-sectional study comprised 9,159 adults (5,052 men, 4,107 women) who participated in a comprehensive health checkup program. IR was evaluated by the homeostasis model assessment of IR (HOMA-IR) and was considered to be present when the HOMA-IR score was >2. NAFLD was evaluated by ultrasound examination. Elevated alanine aminotransferase (ALT) was defined as >40 IU/L in men and >35 IU/L in women. Logistic regression was performed to determine the odds ratios (ORs) and 95% confidence intervals (95% CIs) for NAFLD, IR, and ALT according to categorized levels of WC. RESULTS: NAFLD was found in 2,553 (27.9%) of the participants (82.6% men, 17.4% women), while IR and elevated ALT were found in 17.2% (68.1% men, 31.9% women) and 10% (83% men, 17% women), respectively. After adjusting for confounding factors, the prevalence of NAFLD, IR, and elevated ALT was significantly associated with increases in WC quartile: highest quartile for NAFLD in men, OR=15.539, 95% CI=12.687-19.033; highest quartile for NAFLD in women, OR=48.732, 95% CI=23.918-99.288 (P<0.001); and highest quartile for IR in men, OR=17.576, 95% CI=13.283-23.255; highest quartile for IR in women, OR=11.078, 95% CI=7.813-15.708 (P<0.001); highest quartile for elevated ALT in men, OR=7.952, 95% CI=6.046-10.459; and highest quartile for elevated ALT in women, OR=8.487, 95% CI=4.679-15.395 (P<0.001). CONCLUSIONS: WC contributes to IR and NAFLD in apparently healthy Korean adults, and thus may be an important factor in the development of IR and NAFLD. SN - 2287-285X UR - https://www.unboundmedicine.com/medline/citation/23837138/The_influence_of_waist_circumference_on_insulin_resistance_and_nonalcoholic_fatty_liver_disease_in_apparently_healthy_Korean_adults_ L2 - http://e-cmh.org/journal/view.php?doi=10.3350/cmh.2013.19.2.140 DB - PRIME DP - Unbound Medicine ER -