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The chronic toxicity of ZnO nanoparticles and ZnCl2 to Daphnia magna and the use of different methods to assess nanoparticle aggregation and dissolution.
Nanotoxicology. 2014 Nov; 8(7):709-17.N

Abstract

In this study, the effect of ZnO nanoparticles and ZnCl2 on growth, reproduction and accumulation of zinc in Daphnia magna was determined in a 21-day chronic toxicity test. A variety of techniques were used to distinguish the free zinc ion, dissolved, nanoparticle and aggregated zinc fraction in the Daphnia test medium. The results showed similar chronic effects on growth, reproduction and accumulation for the ZnO nanoparticles (EC10, 20, 50 reproduction: 0.030, 0.049, 0.112 mg Zn/l) and the ZnCl2 (EC10, 20, 50 reproduction: 0.014, 0.027, 0.082 mg Zn/l). A large fraction of the nanoparticles rapidly dissolved after introduction in the exposure medium. Aggregation of nanoparticles was also observed but within 48 h of exposure most of these ZnO aggregates were dissolved. Based on the combined dissolution kinetics and toxicity results, it can be concluded that the toxicological effects of ZnO nanoparticles at the chronic level can be largely attributed to the dissolved fraction rather than the nanoparticles or initially formed aggregates.

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Authors+Show Affiliations

Adam N
Department of Biology (Systemic Physiological and Ecotoxicological Research), University of Antwerp , Antwerp , Belgium.
Schmitt C
No affiliation info available
Galceran J
No affiliation info available
Companys E
No affiliation info available
Vakurov A
No affiliation info available
Wallace R
No affiliation info available
Knapen D
No affiliation info available
Blust R
No affiliation info available

MeSH

Analysis of VarianceAnimalsChloridesCulture MediaDaphniaMetal NanoparticlesParticle SizeReproductionSolubilityToxicity Tests, ChronicZinc CompoundsZinc Oxide

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23837602

Citation

Adam, Nathalie, et al. "The Chronic Toxicity of ZnO Nanoparticles and ZnCl2 to Daphnia Magna and the Use of Different Methods to Assess Nanoparticle Aggregation and Dissolution." Nanotoxicology, vol. 8, no. 7, 2014, pp. 709-17.
Adam N, Schmitt C, Galceran J, et al. The chronic toxicity of ZnO nanoparticles and ZnCl2 to Daphnia magna and the use of different methods to assess nanoparticle aggregation and dissolution. Nanotoxicology. 2014;8(7):709-17.
Adam, N., Schmitt, C., Galceran, J., Companys, E., Vakurov, A., Wallace, R., Knapen, D., & Blust, R. (2014). The chronic toxicity of ZnO nanoparticles and ZnCl2 to Daphnia magna and the use of different methods to assess nanoparticle aggregation and dissolution. Nanotoxicology, 8(7), 709-17. https://doi.org/10.3109/17435390.2013.822594
Adam N, et al. The Chronic Toxicity of ZnO Nanoparticles and ZnCl2 to Daphnia Magna and the Use of Different Methods to Assess Nanoparticle Aggregation and Dissolution. Nanotoxicology. 2014;8(7):709-17. PubMed PMID: 23837602.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The chronic toxicity of ZnO nanoparticles and ZnCl2 to Daphnia magna and the use of different methods to assess nanoparticle aggregation and dissolution. AU - Adam,Nathalie, AU - Schmitt,Claudia, AU - Galceran,Josep, AU - Companys,Encarna, AU - Vakurov,Alexander, AU - Wallace,Rachel, AU - Knapen,Dries, AU - Blust,Ronny, Y1 - 2013/07/29/ PY - 2013/7/11/entrez PY - 2013/7/11/pubmed PY - 2014/7/16/medline SP - 709 EP - 17 JF - Nanotoxicology JO - Nanotoxicology VL - 8 IS - 7 N2 - In this study, the effect of ZnO nanoparticles and ZnCl2 on growth, reproduction and accumulation of zinc in Daphnia magna was determined in a 21-day chronic toxicity test. A variety of techniques were used to distinguish the free zinc ion, dissolved, nanoparticle and aggregated zinc fraction in the Daphnia test medium. The results showed similar chronic effects on growth, reproduction and accumulation for the ZnO nanoparticles (EC10, 20, 50 reproduction: 0.030, 0.049, 0.112 mg Zn/l) and the ZnCl2 (EC10, 20, 50 reproduction: 0.014, 0.027, 0.082 mg Zn/l). A large fraction of the nanoparticles rapidly dissolved after introduction in the exposure medium. Aggregation of nanoparticles was also observed but within 48 h of exposure most of these ZnO aggregates were dissolved. Based on the combined dissolution kinetics and toxicity results, it can be concluded that the toxicological effects of ZnO nanoparticles at the chronic level can be largely attributed to the dissolved fraction rather than the nanoparticles or initially formed aggregates. SN - 1743-5404 UR - https://www.unboundmedicine.com/medline/citation/23837602/The_chronic_toxicity_of_ZnO_nanoparticles_and_ZnCl2_to_Daphnia_magna_and_the_use_of_different_methods_to_assess_nanoparticle_aggregation_and_dissolution_ L2 - https://www.tandfonline.com/doi/full/10.3109/17435390.2013.822594 DB - PRIME DP - Unbound Medicine ER -