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Treating cow's milk protein allergy: a double-blind randomized trial comparing two extensively hydrolysed formulas with probiotics.
Acta Paediatr. 2013 Oct; 102(10):990-8.AP

Abstract

AIM

The treatment for cow's milk protein allergy (CMPA) is a diet with an extensive hydrolysate. This study aimed to determine whether a whey (eWH) or casein hydrolysate (eCH) is the best option.

METHODS

Infants with suspected CMPA were treated with an eWH or eCH, and efficacy was assessed with a symptom-based score developed by the authors. Diagnosis of CMPA was based on a positive challenge. If positive, the same eHF/eCH was continued. If negative, a standard starter and follow-up formula were given up to the age of 12 months.

RESULTS

An open challenge was performed on 85/116 (73%) infants suspected of CMPA on clinical grounds and was positive in 59/85 (69%). After 1 month, the symptom-based scores in both groups showed significant statistical and clinical reductions, and total and specific IgE and skin prick test results were similar. Both hydrolysates were enriched with probiotics, which were recovered in the gastrointestinal flora. The eWH-Standard Formula sequence led to better growth at the age of 1 year than the other three feeding regimens tested.

CONCLUSION

The eWH and eCH are equally effective. The symptom-based score is a useful tool to evaluate the efficacy of dietary treatment in infants with CMPA.

Authors+Show Affiliations

Universitair KinderZiekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium. yvan.vandenplas@uzbrussel.beNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23837862

Citation

Vandenplas, Yvan, et al. "Treating Cow's Milk Protein Allergy: a Double-blind Randomized Trial Comparing Two Extensively Hydrolysed Formulas With Probiotics." Acta Paediatrica (Oslo, Norway : 1992), vol. 102, no. 10, 2013, pp. 990-8.
Vandenplas Y, Steenhout P, Planoudis Y, et al. Treating cow's milk protein allergy: a double-blind randomized trial comparing two extensively hydrolysed formulas with probiotics. Acta Paediatr. 2013;102(10):990-8.
Vandenplas, Y., Steenhout, P., Planoudis, Y., & Grathwohl, D. (2013). Treating cow's milk protein allergy: a double-blind randomized trial comparing two extensively hydrolysed formulas with probiotics. Acta Paediatrica (Oslo, Norway : 1992), 102(10), 990-8. https://doi.org/10.1111/apa.12349
Vandenplas Y, et al. Treating Cow's Milk Protein Allergy: a Double-blind Randomized Trial Comparing Two Extensively Hydrolysed Formulas With Probiotics. Acta Paediatr. 2013;102(10):990-8. PubMed PMID: 23837862.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treating cow's milk protein allergy: a double-blind randomized trial comparing two extensively hydrolysed formulas with probiotics. AU - Vandenplas,Yvan, AU - Steenhout,Philippe, AU - Planoudis,Yannis, AU - Grathwohl,Dominik, AU - ,, Y1 - 2013/08/05/ PY - 2013/02/28/received PY - 2013/05/05/revised PY - 2013/07/04/accepted PY - 2013/7/11/entrez PY - 2013/7/11/pubmed PY - 2014/4/20/medline KW - (extensive) Hydrolysate KW - Cow's milk protein allergy KW - Infant nutrition KW - Probiotic SP - 990 EP - 8 JF - Acta paediatrica (Oslo, Norway : 1992) JO - Acta Paediatr VL - 102 IS - 10 N2 - AIM: The treatment for cow's milk protein allergy (CMPA) is a diet with an extensive hydrolysate. This study aimed to determine whether a whey (eWH) or casein hydrolysate (eCH) is the best option. METHODS: Infants with suspected CMPA were treated with an eWH or eCH, and efficacy was assessed with a symptom-based score developed by the authors. Diagnosis of CMPA was based on a positive challenge. If positive, the same eHF/eCH was continued. If negative, a standard starter and follow-up formula were given up to the age of 12 months. RESULTS: An open challenge was performed on 85/116 (73%) infants suspected of CMPA on clinical grounds and was positive in 59/85 (69%). After 1 month, the symptom-based scores in both groups showed significant statistical and clinical reductions, and total and specific IgE and skin prick test results were similar. Both hydrolysates were enriched with probiotics, which were recovered in the gastrointestinal flora. The eWH-Standard Formula sequence led to better growth at the age of 1 year than the other three feeding regimens tested. CONCLUSION: The eWH and eCH are equally effective. The symptom-based score is a useful tool to evaluate the efficacy of dietary treatment in infants with CMPA. SN - 1651-2227 UR - https://www.unboundmedicine.com/medline/citation/23837862/Treating_cow's_milk_protein_allergy:_a_double_blind_randomized_trial_comparing_two_extensively_hydrolysed_formulas_with_probiotics_ L2 - https://doi.org/10.1111/apa.12349 DB - PRIME DP - Unbound Medicine ER -