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Orcinol glucoside produces antidepressant effects by blocking the behavioural and neuronal deficits caused by chronic stress.
Eur Neuropsychopharmacol. 2014 Jan; 24(1):172-80.EN

Abstract

This study focused on the antidepressant potential of orcinol glucoside (OG) and its possible mechanisms of action. We established a depressed rat model using 3 consecutive weeks of chronic unpredictable mild stress (CUMS). The antidepressant-like effect of OG was revealed using the sucrose preference test, the open field test, the forced swimming test (FST), and the tail suspension test (TST). The activity of the hypothalamic-pituitary-adrenal (HPA) axis was evaluated by detecting the serum corticosterone (CORT) concentrations and mRNA expression of corticotrophin-releasing hormone (CRH) in the hypothalamus. The protein expression levels of brain-derived neurotrophic factor (BDNF) and total phosphorylated-ERK1/2 were detected by western blot. The results showed that OG treatment (1.5, 3, or 6mg/kg) alleviated the depression-like behaviour of rats under CUMS, as indicated by the increased sucrose preference and the decreased immobility in both the FST and TST, although the rearing frequency in the open field test increased only in the group that received the lowest dose (1.5mg/kg OG). Rats that received OG treatment exhibited reduced serum CORT levels and CRH mRNA expression in the hypothalamus, suggesting that the hyperactivity of the HPA axis in CUMS rats was reversed by OG treatment. Moreover, OG treatment upregulated the protein levels of BDNF and phosphorylated-ERK1/2 in the hippocampus, even above control levels. Our findings suggest that OG improved depressive behaviour in CUMS rats by downregulating HPA axis hyperactivity and increasing BDNF expression and ERK1/2 phosphorylation in the hippocampus.

Authors+Show Affiliations

Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, PR China.Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, PR China.Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, PR China.Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, PR China.Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, PR China.Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, PR China.Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, PR China. Electronic address: ln0110@sina.com.Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, PR China. Electronic address: cfhchina@sohu.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23838013

Citation

Ge, Jin-Fang, et al. "Orcinol Glucoside Produces Antidepressant Effects By Blocking the Behavioural and Neuronal Deficits Caused By Chronic Stress." European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, vol. 24, no. 1, 2014, pp. 172-80.
Ge JF, Gao WC, Cheng WM, et al. Orcinol glucoside produces antidepressant effects by blocking the behavioural and neuronal deficits caused by chronic stress. Eur Neuropsychopharmacol. 2014;24(1):172-80.
Ge, J. F., Gao, W. C., Cheng, W. M., Lu, W. L., Tang, J., Peng, L., Li, N., & Chen, F. H. (2014). Orcinol glucoside produces antidepressant effects by blocking the behavioural and neuronal deficits caused by chronic stress. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, 24(1), 172-80. https://doi.org/10.1016/j.euroneuro.2013.05.007
Ge JF, et al. Orcinol Glucoside Produces Antidepressant Effects By Blocking the Behavioural and Neuronal Deficits Caused By Chronic Stress. Eur Neuropsychopharmacol. 2014;24(1):172-80. PubMed PMID: 23838013.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Orcinol glucoside produces antidepressant effects by blocking the behavioural and neuronal deficits caused by chronic stress. AU - Ge,Jin-Fang, AU - Gao,Wen-Chao, AU - Cheng,Wen-Ming, AU - Lu,Wei-Li, AU - Tang,Jie, AU - Peng,Lei, AU - Li,Ning, AU - Chen,Fei-Hu, Y1 - 2013/07/06/ PY - 2013/01/09/received PY - 2013/05/18/revised PY - 2013/05/24/accepted PY - 2013/7/11/entrez PY - 2013/7/11/pubmed PY - 2014/9/13/medline KW - Antidepressant KW - Brain-derived neurotrophic factor (BDNF) KW - Extracellular signal-regulated kinase (ERK) KW - Hypothalamic–pituitary–adrenal (HPA) axis KW - Orcinol glucoside SP - 172 EP - 80 JF - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology JO - Eur Neuropsychopharmacol VL - 24 IS - 1 N2 - This study focused on the antidepressant potential of orcinol glucoside (OG) and its possible mechanisms of action. We established a depressed rat model using 3 consecutive weeks of chronic unpredictable mild stress (CUMS). The antidepressant-like effect of OG was revealed using the sucrose preference test, the open field test, the forced swimming test (FST), and the tail suspension test (TST). The activity of the hypothalamic-pituitary-adrenal (HPA) axis was evaluated by detecting the serum corticosterone (CORT) concentrations and mRNA expression of corticotrophin-releasing hormone (CRH) in the hypothalamus. The protein expression levels of brain-derived neurotrophic factor (BDNF) and total phosphorylated-ERK1/2 were detected by western blot. The results showed that OG treatment (1.5, 3, or 6mg/kg) alleviated the depression-like behaviour of rats under CUMS, as indicated by the increased sucrose preference and the decreased immobility in both the FST and TST, although the rearing frequency in the open field test increased only in the group that received the lowest dose (1.5mg/kg OG). Rats that received OG treatment exhibited reduced serum CORT levels and CRH mRNA expression in the hypothalamus, suggesting that the hyperactivity of the HPA axis in CUMS rats was reversed by OG treatment. Moreover, OG treatment upregulated the protein levels of BDNF and phosphorylated-ERK1/2 in the hippocampus, even above control levels. Our findings suggest that OG improved depressive behaviour in CUMS rats by downregulating HPA axis hyperactivity and increasing BDNF expression and ERK1/2 phosphorylation in the hippocampus. SN - 1873-7862 UR - https://www.unboundmedicine.com/medline/citation/23838013/Orcinol_glucoside_produces_antidepressant_effects_by_blocking_the_behavioural_and_neuronal_deficits_caused_by_chronic_stress_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0924-977X(13)00168-5 DB - PRIME DP - Unbound Medicine ER -