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Alopecia areata: infiltration of Th17 cells in the dermis, particularly around hair follicles.
Dermatology. 2013; 226(4):333-6.D

Abstract

BACKGROUND

The precise pathogenesis of alopecia areata remains unknown, although this disease seems to be triggered by helper T cell infiltration in hair follicles. Recent studies of psoriasis and vitiligo have demonstrated the involvement of Th17 cells. Psoriasis and vitiligo occasionally develop concomitantly or inversely in patients with alopecia areata.

OBJECTIVE

The aim of this study was to determine whether Th17 cells are present in the affected lesions of alopecia areata.

METHODS

We performed immunofluorescent staining of representative immunocompetent cells that had infiltrated into the skin of the scalp in 4 individuals with alopecia areata (single patchy alopecia areata, multiple patchy alopecia areata, alopecia totalis and alopecia universalis).

RESULTS

We found the infiltration of CD4(+)IL-17A(+) Th17 cells in the dermis, particularly around hair follicles, in all 4 cases.

CONCLUSIONS

These findings suggest the possibility that alopecia areata is induced by a Th17 cell-associated autoimmune mechanism.

Authors+Show Affiliations

Department of Dermatology, Integrated Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23838575

Citation

Tanemura, Atsushi, et al. "Alopecia Areata: Infiltration of Th17 Cells in the Dermis, Particularly Around Hair Follicles." Dermatology (Basel, Switzerland), vol. 226, no. 4, 2013, pp. 333-6.
Tanemura A, Oiso N, Nakano M, et al. Alopecia areata: infiltration of Th17 cells in the dermis, particularly around hair follicles. Dermatology (Basel). 2013;226(4):333-6.
Tanemura, A., Oiso, N., Nakano, M., Itoi, S., Kawada, A., & Katayama, I. (2013). Alopecia areata: infiltration of Th17 cells in the dermis, particularly around hair follicles. Dermatology (Basel, Switzerland), 226(4), 333-6. https://doi.org/10.1159/000350933
Tanemura A, et al. Alopecia Areata: Infiltration of Th17 Cells in the Dermis, Particularly Around Hair Follicles. Dermatology (Basel). 2013;226(4):333-6. PubMed PMID: 23838575.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alopecia areata: infiltration of Th17 cells in the dermis, particularly around hair follicles. AU - Tanemura,Atsushi, AU - Oiso,Naoki, AU - Nakano,Mayuko, AU - Itoi,Saori, AU - Kawada,Akira, AU - Katayama,Ichiro, Y1 - 2013/07/04/ PY - 2012/12/10/received PY - 2013/03/18/accepted PY - 2013/7/11/entrez PY - 2013/7/11/pubmed PY - 2014/5/29/medline SP - 333 EP - 6 JF - Dermatology (Basel, Switzerland) JO - Dermatology (Basel) VL - 226 IS - 4 N2 - BACKGROUND: The precise pathogenesis of alopecia areata remains unknown, although this disease seems to be triggered by helper T cell infiltration in hair follicles. Recent studies of psoriasis and vitiligo have demonstrated the involvement of Th17 cells. Psoriasis and vitiligo occasionally develop concomitantly or inversely in patients with alopecia areata. OBJECTIVE: The aim of this study was to determine whether Th17 cells are present in the affected lesions of alopecia areata. METHODS: We performed immunofluorescent staining of representative immunocompetent cells that had infiltrated into the skin of the scalp in 4 individuals with alopecia areata (single patchy alopecia areata, multiple patchy alopecia areata, alopecia totalis and alopecia universalis). RESULTS: We found the infiltration of CD4(+)IL-17A(+) Th17 cells in the dermis, particularly around hair follicles, in all 4 cases. CONCLUSIONS: These findings suggest the possibility that alopecia areata is induced by a Th17 cell-associated autoimmune mechanism. SN - 1421-9832 UR - https://www.unboundmedicine.com/medline/citation/23838575/Alopecia_areata:_infiltration_of_Th17_cells_in_the_dermis_particularly_around_hair_follicles_ L2 - https://www.karger.com?DOI=10.1159/000350933 DB - PRIME DP - Unbound Medicine ER -