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Prevalence and clinical characteristics of patients with true resistant hypertension in central and Eastern Europe: data from the BP-CARE study.
J Hypertens. 2013 Oct; 31(10):2018-24.JH

Abstract

OBJECTIVE

Scanty information is available on the clinical characteristics of resistant hypertension in Central and East European countries. The Blood Pressure (BP) control rate and CArdiovascular Risk profilE (BP-CARE) study allowed us to assess the prevalence and the main clinical features of resistant hypertension in this population.

DESIGN AND METHOD

The study was carried out in 1312 treated hypertensive patients living in nine Central and East European countries.

RESULTS

Four hundred and twenty-three patients had apparent resistant hypertension, of whom 168 had pseudo-resistant hypertension (noncompliant/white-coat) and 255 were true treatment-resistant hypertension patients (TRH). Clinical BP values in TRH amounted to 157.4±16.9/91.8±10.0 mmHg despite the daily use of 3.6±0.7 drugs. Their 24-h BP values were 149.5±16.5/97.5±9.8 mmHg. Compared to controlled hypertensive patients (n=368) and uncontrolled nonresistant hypertensive patients (n=521), TRH were older with a greater prevalence of women. They showed a higher rate of previous cardiovascular events and a very high cardiovascular risk profile. Estimated glomerular filtration rate was significantly lower in TRH as compared to controlled hypertensive patients and uncontrolled nonresistant hypertensive patients. Overall, target organ damage was more frequently detected in TRH than in controlled hypertensive patients and uncontrolled nonresistant hypertensive patients. The factor most frequently associated with TRH was severity of hypertension followed by age, total cholesterol, BMI and history of heart failure.

CONCLUSIONS

The present study provides evidence that the prevalence of TRH in Central and East European countries is similar to that found in Western Europe and USA. It also shows the very high cardiovascular risk of TRH and the elevated association of this condition with obesity, renal failure, organ damage and history of cardiovascular events.

Authors+Show Affiliations

aClinica Medica, Università Milano-Bicocca, Ospedale San Gerardo dei Tintori, Monza bIstituto Auxologico Italiano, Ospedale San Luca, Milan, Italy cCenter for Cardiovascular Prevention, Thomayer Hospital and Department of Preventive Cardiology, Institute of Clinical and Experimental Medicine, Prague, Czech Republic dPharmacology Department and INSERM U970 Hopital Europeen Georges Pompidou, Assistance-Publique Hopitaux de Paris, Paris-Derscartes University, France eDepartment of Hypertension and Diabetology, Medical University of Gdansk, Gdansk, Poland fInternal Medicine, Hospital Clinico, University of Valencia, Valencia, Spain gIRCCS MultiMedica, Sesto San Giovanni, Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23838657

Citation

Brambilla, Gianmaria, et al. "Prevalence and Clinical Characteristics of Patients With True Resistant Hypertension in Central and Eastern Europe: Data From the BP-CARE Study." Journal of Hypertension, vol. 31, no. 10, 2013, pp. 2018-24.
Brambilla G, Bombelli M, Seravalle G, et al. Prevalence and clinical characteristics of patients with true resistant hypertension in central and Eastern Europe: data from the BP-CARE study. J Hypertens. 2013;31(10):2018-24.
Brambilla, G., Bombelli, M., Seravalle, G., Cifkova, R., Laurent, S., Narkiewicz, K., Facchetti, R., Redon, J., Mancia, G., & Grassi, G. (2013). Prevalence and clinical characteristics of patients with true resistant hypertension in central and Eastern Europe: data from the BP-CARE study. Journal of Hypertension, 31(10), 2018-24. https://doi.org/10.1097/HJH.0b013e328363823f
Brambilla G, et al. Prevalence and Clinical Characteristics of Patients With True Resistant Hypertension in Central and Eastern Europe: Data From the BP-CARE Study. J Hypertens. 2013;31(10):2018-24. PubMed PMID: 23838657.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and clinical characteristics of patients with true resistant hypertension in central and Eastern Europe: data from the BP-CARE study. AU - Brambilla,Gianmaria, AU - Bombelli,Michele, AU - Seravalle,Gino, AU - Cifkova,Renata, AU - Laurent,Stephane, AU - Narkiewicz,Krzysztof, AU - Facchetti,Rita, AU - Redon,Josep, AU - Mancia,Giuseppe, AU - Grassi,Guido, PY - 2013/7/11/entrez PY - 2013/7/11/pubmed PY - 2014/5/30/medline SP - 2018 EP - 24 JF - Journal of hypertension JO - J Hypertens VL - 31 IS - 10 N2 - OBJECTIVE: Scanty information is available on the clinical characteristics of resistant hypertension in Central and East European countries. The Blood Pressure (BP) control rate and CArdiovascular Risk profilE (BP-CARE) study allowed us to assess the prevalence and the main clinical features of resistant hypertension in this population. DESIGN AND METHOD: The study was carried out in 1312 treated hypertensive patients living in nine Central and East European countries. RESULTS: Four hundred and twenty-three patients had apparent resistant hypertension, of whom 168 had pseudo-resistant hypertension (noncompliant/white-coat) and 255 were true treatment-resistant hypertension patients (TRH). Clinical BP values in TRH amounted to 157.4±16.9/91.8±10.0 mmHg despite the daily use of 3.6±0.7 drugs. Their 24-h BP values were 149.5±16.5/97.5±9.8 mmHg. Compared to controlled hypertensive patients (n=368) and uncontrolled nonresistant hypertensive patients (n=521), TRH were older with a greater prevalence of women. They showed a higher rate of previous cardiovascular events and a very high cardiovascular risk profile. Estimated glomerular filtration rate was significantly lower in TRH as compared to controlled hypertensive patients and uncontrolled nonresistant hypertensive patients. Overall, target organ damage was more frequently detected in TRH than in controlled hypertensive patients and uncontrolled nonresistant hypertensive patients. The factor most frequently associated with TRH was severity of hypertension followed by age, total cholesterol, BMI and history of heart failure. CONCLUSIONS: The present study provides evidence that the prevalence of TRH in Central and East European countries is similar to that found in Western Europe and USA. It also shows the very high cardiovascular risk of TRH and the elevated association of this condition with obesity, renal failure, organ damage and history of cardiovascular events. SN - 1473-5598 UR - https://www.unboundmedicine.com/medline/citation/23838657/Prevalence_and_clinical_characteristics_of_patients_with_true_resistant_hypertension_in_central_and_Eastern_Europe:_data_from_the_BP_CARE_study_ L2 - https://doi.org/10.1097/HJH.0b013e328363823f DB - PRIME DP - Unbound Medicine ER -