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Ameliorative effect of Noni fruit extract on streptozotocin-induced memory impairment in mice.
Behav Pharmacol. 2013 Aug; 24(4):307-19.BP

Abstract

This study evaluated the effects of a standardized ethyl acetate extract of Morinda citrifolia L. (Noni) fruit on impairment of memory, brain energy metabolism, and cholinergic function in intracerebral streptozotocin (STZ)-treated mice. STZ (0.5 mg/kg) was administered twice at an interval of 48 h. Noni (50 and 100 mg/kg, postoperatively) was administered for 21 days following STZ administration. Memory function was evaluated using Morris Water Maze and passive avoidance tests, and brain levels of cholinergic function, oxidative stress, energy metabolism, and brain-derived neurotrophic factor (BDNF) were estimated. STZ caused memory impairment in Morris Water Maze and passive avoidance tests along with reduced brain levels of ATP, BDNF, and acetylcholine and increased acetylcholinesterase activity and oxidative stress. Treatment with Noni extract (100 mg/kg) prevented the STZ-induced memory impairment in both behavioral tests along with reduced oxidative stress and acetylcholinesterase activity, and increased brain levels of BDNF, acetylcholine, and ATP level. The study shows the beneficial effects of Noni fruit against STZ-induced memory impairment, which may be attributed to improved brain energy metabolism, cholinergic neurotransmission, BDNF, and antioxidative action.

Authors+Show Affiliations

Division of Pharmaceutics, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23838966

Citation

Pachauri, Shakti D., et al. "Ameliorative Effect of Noni Fruit Extract On Streptozotocin-induced Memory Impairment in Mice." Behavioural Pharmacology, vol. 24, no. 4, 2013, pp. 307-19.
Pachauri SD, Verma PR, Dwivedi AK, et al. Ameliorative effect of Noni fruit extract on streptozotocin-induced memory impairment in mice. Behav Pharmacol. 2013;24(4):307-19.
Pachauri, S. D., Verma, P. R., Dwivedi, A. K., Tota, S., Khandelwal, K., Saxena, J. K., & Nath, C. (2013). Ameliorative effect of Noni fruit extract on streptozotocin-induced memory impairment in mice. Behavioural Pharmacology, 24(4), 307-19. https://doi.org/10.1097/FBP.0b013e3283637a51
Pachauri SD, et al. Ameliorative Effect of Noni Fruit Extract On Streptozotocin-induced Memory Impairment in Mice. Behav Pharmacol. 2013;24(4):307-19. PubMed PMID: 23838966.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ameliorative effect of Noni fruit extract on streptozotocin-induced memory impairment in mice. AU - Pachauri,Shakti D, AU - Verma,Priya Ranjan P, AU - Dwivedi,Anil K, AU - Tota,Santoshkumar, AU - Khandelwal,Kiran, AU - Saxena,Jitendra K, AU - Nath,Chandishwar, PY - 2013/7/11/entrez PY - 2013/7/11/pubmed PY - 2013/11/12/medline SP - 307 EP - 19 JF - Behavioural pharmacology JO - Behav Pharmacol VL - 24 IS - 4 N2 - This study evaluated the effects of a standardized ethyl acetate extract of Morinda citrifolia L. (Noni) fruit on impairment of memory, brain energy metabolism, and cholinergic function in intracerebral streptozotocin (STZ)-treated mice. STZ (0.5 mg/kg) was administered twice at an interval of 48 h. Noni (50 and 100 mg/kg, postoperatively) was administered for 21 days following STZ administration. Memory function was evaluated using Morris Water Maze and passive avoidance tests, and brain levels of cholinergic function, oxidative stress, energy metabolism, and brain-derived neurotrophic factor (BDNF) were estimated. STZ caused memory impairment in Morris Water Maze and passive avoidance tests along with reduced brain levels of ATP, BDNF, and acetylcholine and increased acetylcholinesterase activity and oxidative stress. Treatment with Noni extract (100 mg/kg) prevented the STZ-induced memory impairment in both behavioral tests along with reduced oxidative stress and acetylcholinesterase activity, and increased brain levels of BDNF, acetylcholine, and ATP level. The study shows the beneficial effects of Noni fruit against STZ-induced memory impairment, which may be attributed to improved brain energy metabolism, cholinergic neurotransmission, BDNF, and antioxidative action. SN - 1473-5849 UR - https://www.unboundmedicine.com/medline/citation/23838966/Ameliorative_effect_of_Noni_fruit_extract_on_streptozotocin_induced_memory_impairment_in_mice_ L2 - https://doi.org/10.1097/FBP.0b013e3283637a51 DB - PRIME DP - Unbound Medicine ER -