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Locomotor stimulant and discriminative stimulus effects of 'bath salt' cathinones.
Behav Pharmacol. 2013 Sep; 24(5-6):437-47.BP

Abstract

A number of psychostimulant-like cathinone compounds are being sold as 'legal' alternatives to methamphetamine or cocaine. The purpose of these experiments was to determine whether cathinone compounds stimulate motor activity and have discriminative stimulus effects similar to those of cocaine and/or methamphetamine. 3,4-Methylenedioxypyrovalerone (MDPV), methylone, mephedrone, naphyrone, flephedrone, and butylone were tested for locomotor stimulant effects in mice and subsequently for substitution in rats trained to discriminate cocaine (10 mg/kg, intraperitoneally) or methamphetamine (1 mg/kg, intraperitoneally) from saline. All compounds fully substituted for the discriminative stimulus effects of cocaine and methamphetamine. Several commonly marketed cathinones produce discriminative stimulus effects comparable with those of cocaine and methamphetamine, which suggests that these compounds are likely to have similar abuse liabilities. MDPV and naphyrone produced locomotor stimulant effects that lasted much longer than those of cocaine or methamphetamine and therefore may be of particular concern, particularly because MDPV is one of the most commonly found substances associated with emergency room visits because of adverse effects of taking 'bath salts'.

Authors+Show Affiliations

Department of Pharmacology & Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107-2699, USA. michael.gatch@unthsc.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

23839026

Citation

Gatch, Michael B., et al. "Locomotor Stimulant and Discriminative Stimulus Effects of 'bath Salt' Cathinones." Behavioural Pharmacology, vol. 24, no. 5-6, 2013, pp. 437-47.
Gatch MB, Taylor CM, Forster MJ. Locomotor stimulant and discriminative stimulus effects of 'bath salt' cathinones. Behav Pharmacol. 2013;24(5-6):437-47.
Gatch, M. B., Taylor, C. M., & Forster, M. J. (2013). Locomotor stimulant and discriminative stimulus effects of 'bath salt' cathinones. Behavioural Pharmacology, 24(5-6), 437-47. https://doi.org/10.1097/FBP.0b013e328364166d
Gatch MB, Taylor CM, Forster MJ. Locomotor Stimulant and Discriminative Stimulus Effects of 'bath Salt' Cathinones. Behav Pharmacol. 2013;24(5-6):437-47. PubMed PMID: 23839026.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Locomotor stimulant and discriminative stimulus effects of 'bath salt' cathinones. AU - Gatch,Michael B, AU - Taylor,Cynthia M, AU - Forster,Michael J, PY - 2013/7/11/entrez PY - 2013/7/11/pubmed PY - 2013/10/30/medline SP - 437 EP - 47 JF - Behavioural pharmacology JO - Behav Pharmacol VL - 24 IS - 5-6 N2 - A number of psychostimulant-like cathinone compounds are being sold as 'legal' alternatives to methamphetamine or cocaine. The purpose of these experiments was to determine whether cathinone compounds stimulate motor activity and have discriminative stimulus effects similar to those of cocaine and/or methamphetamine. 3,4-Methylenedioxypyrovalerone (MDPV), methylone, mephedrone, naphyrone, flephedrone, and butylone were tested for locomotor stimulant effects in mice and subsequently for substitution in rats trained to discriminate cocaine (10 mg/kg, intraperitoneally) or methamphetamine (1 mg/kg, intraperitoneally) from saline. All compounds fully substituted for the discriminative stimulus effects of cocaine and methamphetamine. Several commonly marketed cathinones produce discriminative stimulus effects comparable with those of cocaine and methamphetamine, which suggests that these compounds are likely to have similar abuse liabilities. MDPV and naphyrone produced locomotor stimulant effects that lasted much longer than those of cocaine or methamphetamine and therefore may be of particular concern, particularly because MDPV is one of the most commonly found substances associated with emergency room visits because of adverse effects of taking 'bath salts'. SN - 1473-5849 UR - https://www.unboundmedicine.com/medline/citation/23839026/Locomotor_stimulant_and_discriminative_stimulus_effects_of_'bath_salt'_cathinones_ L2 - http://dx.doi.org/10.1097/FBP.0b013e328364166d DB - PRIME DP - Unbound Medicine ER -