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Purpura fulminans after therapeutic hypothermia in an asphyxiated neonate with streptococcemia.
Am J Perinatol 2014; 31(4):257-60AJ

Abstract

OBJECTIVE

Therapeutic hypothermia is an established therapeutic regimen in severely asphyxiated term neonates. The amount of cerebral injury is reduced resulting in an improved neurologic outcome. Therapeutic hypothermia-induced side effects mostly affect the circulatory system, kidney, and liver. However, asphyxia and hypothermia in itself reduce the hemostatic capacity of each individual organism.

STUDY DESIGN

A case of a neonate with severe asphyxia and purpura fulminans after hypothermia is described.

RESULTS AND CONCLUSION

Although purpura fulminans cannot be attributed to hypothermia solely, the influence of hypothermia on hemostasis may have promoted severe coagulopathy with a fatal outcome. Further studies are necessary to reveal therapeutic hypothermia as a trigger for severe coagulopathies in asphyxiated neonates, especially in those with sepsis and overt coagulopathy prior to therapeutic hypothermia.

Authors+Show Affiliations

Division of Neonatology, Department of Pediatrics, JW Goethe-University Hospital, Frankfurt, Germany.Division of Neonatology, Department of Pediatrics, JW Goethe-University Hospital, Frankfurt, Germany.Division of Neonatology, Department of Pediatrics, JW Goethe-University Hospital, Frankfurt, Germany.Division of Neonatology, Department of Pediatrics, JW Goethe-University Hospital, Frankfurt, Germany.Division of Neonatology, Department of Pediatrics, JW Goethe-University Hospital, Frankfurt, Germany.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

23839905

Citation

Fischer, Doris, et al. "Purpura Fulminans After Therapeutic Hypothermia in an Asphyxiated Neonate With Streptococcemia." American Journal of Perinatology, vol. 31, no. 4, 2014, pp. 257-60.
Fischer D, Allendorf A, Buxmann H, et al. Purpura fulminans after therapeutic hypothermia in an asphyxiated neonate with streptococcemia. Am J Perinatol. 2014;31(4):257-60.
Fischer, D., Allendorf, A., Buxmann, H., Weiss, K., & Schloesser, R. L. (2014). Purpura fulminans after therapeutic hypothermia in an asphyxiated neonate with streptococcemia. American Journal of Perinatology, 31(4), pp. 257-60. doi:10.1055/s-0033-1349343.
Fischer D, et al. Purpura Fulminans After Therapeutic Hypothermia in an Asphyxiated Neonate With Streptococcemia. Am J Perinatol. 2014;31(4):257-60. PubMed PMID: 23839905.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Purpura fulminans after therapeutic hypothermia in an asphyxiated neonate with streptococcemia. AU - Fischer,Doris, AU - Allendorf,Antje, AU - Buxmann,Horst, AU - Weiss,Katja, AU - Schloesser,Rolf L, Y1 - 2013/07/09/ PY - 2013/7/11/entrez PY - 2013/7/11/pubmed PY - 2014/12/15/medline SP - 257 EP - 60 JF - American journal of perinatology JO - Am J Perinatol VL - 31 IS - 4 N2 - OBJECTIVE: Therapeutic hypothermia is an established therapeutic regimen in severely asphyxiated term neonates. The amount of cerebral injury is reduced resulting in an improved neurologic outcome. Therapeutic hypothermia-induced side effects mostly affect the circulatory system, kidney, and liver. However, asphyxia and hypothermia in itself reduce the hemostatic capacity of each individual organism. STUDY DESIGN: A case of a neonate with severe asphyxia and purpura fulminans after hypothermia is described. RESULTS AND CONCLUSION: Although purpura fulminans cannot be attributed to hypothermia solely, the influence of hypothermia on hemostasis may have promoted severe coagulopathy with a fatal outcome. Further studies are necessary to reveal therapeutic hypothermia as a trigger for severe coagulopathies in asphyxiated neonates, especially in those with sepsis and overt coagulopathy prior to therapeutic hypothermia. SN - 1098-8785 UR - https://www.unboundmedicine.com/medline/citation/23839905/Purpura_fulminans_after_therapeutic_hypothermia_in_an_asphyxiated_neonate_with_streptococcemia L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0033-1349343 DB - PRIME DP - Unbound Medicine ER -