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Evaluation of the effectiveness of malaria vector control measures in urban settings of Dakar by a specific anopheles salivary biomarker.
PLoS One. 2013; 8(6):e66354.Plos

Abstract

Standard entomological methods for evaluating the impact of vector control lack sensitivity in low-malaria-risk areas. The detection of human IgG specific to Anopheles gSG6-P1 salivary antigen reflects a direct measure of human-vector contact. This study aimed to assess the effectiveness of a range of vector control measures (VCMs) in urban settings by using this biomarker approach. The study was conducted from October to December 2008 on 2,774 residents of 45 districts of urban Dakar. IgG responses to gSG6-P1 and the use of malaria VCMs highly varied between districts. At the district level, specific IgG levels significantly increased with age and decreased with season and with VCM use. The use of insecticide-treated nets, by drastically reducing specific IgG levels, was by far the most efficient VCM regardless of age, season or exposure level to mosquito bites. The use of spray bombs was also associated with a significant reduction of specific IgG levels, whereas the use of mosquito coils or electric fans/air conditioning did not show a significant effect. Human IgG response to gSG6-P1 as biomarker of vector exposure represents a reliable alternative for accurately assessing the effectiveness of malaria VCM in low-malaria-risk areas. This biomarker tool could be especially relevant for malaria control monitoring and surveillance programmes in low-exposure/low-transmission settings.

Authors+Show Affiliations

Institut de Recherche pour le Développement (IRD), UMR-MIVEGEC (IRD224-CNRS5290- Universites Montpellier 1 et 2), Montpellier, France. papa-makhtar.drame@ird.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23840448

Citation

Drame, Papa Makhtar, et al. "Evaluation of the Effectiveness of Malaria Vector Control Measures in Urban Settings of Dakar By a Specific Anopheles Salivary Biomarker." PloS One, vol. 8, no. 6, 2013, pp. e66354.
Drame PM, Diallo A, Poinsignon A, et al. Evaluation of the effectiveness of malaria vector control measures in urban settings of Dakar by a specific anopheles salivary biomarker. PLoS One. 2013;8(6):e66354.
Drame, P. M., Diallo, A., Poinsignon, A., Boussari, O., Dos Santos, S., Machault, V., Lalou, R., Cornelie, S., LeHesran, J. Y., & Remoue, F. (2013). Evaluation of the effectiveness of malaria vector control measures in urban settings of Dakar by a specific anopheles salivary biomarker. PloS One, 8(6), e66354. https://doi.org/10.1371/journal.pone.0066354
Drame PM, et al. Evaluation of the Effectiveness of Malaria Vector Control Measures in Urban Settings of Dakar By a Specific Anopheles Salivary Biomarker. PLoS One. 2013;8(6):e66354. PubMed PMID: 23840448.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the effectiveness of malaria vector control measures in urban settings of Dakar by a specific anopheles salivary biomarker. AU - Drame,Papa Makhtar, AU - Diallo,Abdoulaye, AU - Poinsignon,Anne, AU - Boussari,Olayide, AU - Dos Santos,Stephanie, AU - Machault,Vanessa, AU - Lalou,Richard, AU - Cornelie,Sylvie, AU - LeHesran,Jean-Yves, AU - Remoue,Franck, Y1 - 2013/06/20/ PY - 2012/07/13/received PY - 2013/05/09/accepted PY - 2013/7/11/entrez PY - 2013/7/11/pubmed PY - 2014/2/6/medline SP - e66354 EP - e66354 JF - PloS one JO - PLoS One VL - 8 IS - 6 N2 - Standard entomological methods for evaluating the impact of vector control lack sensitivity in low-malaria-risk areas. The detection of human IgG specific to Anopheles gSG6-P1 salivary antigen reflects a direct measure of human-vector contact. This study aimed to assess the effectiveness of a range of vector control measures (VCMs) in urban settings by using this biomarker approach. The study was conducted from October to December 2008 on 2,774 residents of 45 districts of urban Dakar. IgG responses to gSG6-P1 and the use of malaria VCMs highly varied between districts. At the district level, specific IgG levels significantly increased with age and decreased with season and with VCM use. The use of insecticide-treated nets, by drastically reducing specific IgG levels, was by far the most efficient VCM regardless of age, season or exposure level to mosquito bites. The use of spray bombs was also associated with a significant reduction of specific IgG levels, whereas the use of mosquito coils or electric fans/air conditioning did not show a significant effect. Human IgG response to gSG6-P1 as biomarker of vector exposure represents a reliable alternative for accurately assessing the effectiveness of malaria VCM in low-malaria-risk areas. This biomarker tool could be especially relevant for malaria control monitoring and surveillance programmes in low-exposure/low-transmission settings. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/23840448/Evaluation_of_the_effectiveness_of_malaria_vector_control_measures_in_urban_settings_of_Dakar_by_a_specific_anopheles_salivary_biomarker_ L2 - https://dx.plos.org/10.1371/journal.pone.0066354 DB - PRIME DP - Unbound Medicine ER -