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[Research on nourishing and tonifying blood effects of the herb pair consisting of Angelica sinensis and Ligusticum chuanxiong on the basis of drug interaction].
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013 Apr; 33(4):516-21.ZZ

Abstract

OBJECTIVE

To study the pharmacodynamic interaction of nourishing and tonifying blood effects of the herb pair consisting of Angelica sinensis and Ligusticum chuanxiong by response surface method.

METHODS

The blood deficiency rat model was induced by injecting N-acetylphenylhydrazine and cyclophosphamide. The effects of Angelica sinensis and Ligusticum chuanxiong in different proportions (0:1, 1:5, 2:5, 2:3, 1:1, 3:2, 5:2, 5:1, and 1:0) and at different concentrations on the peripheral blood index and the organ indices were observed. Then all indices were integrated to the total nourishing effect value by comprehensive index method. The interaction was analyzed by response surface method. The model parameters were estimated with nonlinear regression. The three-dimensional response surfaces were constructed with Matlab Software.

RESULTS

In the response surface, most compatibility of Angelica sinensis and Ligusticum chuanxiong showed synergistic action, some showed addition action, and few of them showed obvious antagonist action. The proportion of Angelica sinensis and Ligusticum chuanxiong from 4:1 to 2:1 and the dose of Angelica sinensis and Ligusticum chuanxiong from low to high showed addition action, while the other proportions showed obvious addition action at low dose and synergistic action at high dose.

CONCLUSIONS

The research results could provide scientific evidence for reasonable application of Angelica sinensis and Ligusticum chuanxiong in clinics of Chinese medicine. The quantitative analysis on drug interactions of herbal compatibility by response surface method could provide reference for relative studies.

Authors+Show Affiliations

Huang MY
Jiangsu Key Laboratory for High Technology Research of Traditional Chinese Medicine Formula, Nanjing University of Traditional Chinese Medicine, Nanjing, China.
Shang EX
No affiliation info available
Tang YP
No affiliation info available
Guo JM
No affiliation info available
Shi XQ
No affiliation info available
Li WX
No affiliation info available
Duan JA
No affiliation info available

MeSH

Angelica sinensisAnimalsDrug InteractionsDrugs, Chinese HerbalFemaleLigusticumMiceMice, Inbred ICR

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

23841275

Citation

Huang, Mei-yan, et al. "[Research On Nourishing and Tonifying Blood Effects of the Herb Pair Consisting of Angelica Sinensis and Ligusticum Chuanxiong On the Basis of Drug Interaction]." Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine, vol. 33, no. 4, 2013, pp. 516-21.
Huang MY, Shang EX, Tang YP, et al. [Research on nourishing and tonifying blood effects of the herb pair consisting of Angelica sinensis and Ligusticum chuanxiong on the basis of drug interaction]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013;33(4):516-21.
Huang, M. Y., Shang, E. X., Tang, Y. P., Guo, J. M., Shi, X. Q., Li, W. X., & Duan, J. A. (2013). [Research on nourishing and tonifying blood effects of the herb pair consisting of Angelica sinensis and Ligusticum chuanxiong on the basis of drug interaction]. Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine, 33(4), 516-21.
Huang MY, et al. [Research On Nourishing and Tonifying Blood Effects of the Herb Pair Consisting of Angelica Sinensis and Ligusticum Chuanxiong On the Basis of Drug Interaction]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013;33(4):516-21. PubMed PMID: 23841275.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Research on nourishing and tonifying blood effects of the herb pair consisting of Angelica sinensis and Ligusticum chuanxiong on the basis of drug interaction]. AU - Huang,Mei-yan, AU - Shang,Er-xin, AU - Tang,Yu-ping, AU - Guo,Jian-ming, AU - Shi,Xu-qin, AU - Li,Wei-xia, AU - Duan,Jin-ao, PY - 2013/7/12/entrez PY - 2013/7/12/pubmed PY - 2014/4/11/medline SP - 516 EP - 21 JF - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine JO - Zhongguo Zhong Xi Yi Jie He Za Zhi VL - 33 IS - 4 N2 - OBJECTIVE: To study the pharmacodynamic interaction of nourishing and tonifying blood effects of the herb pair consisting of Angelica sinensis and Ligusticum chuanxiong by response surface method. METHODS: The blood deficiency rat model was induced by injecting N-acetylphenylhydrazine and cyclophosphamide. The effects of Angelica sinensis and Ligusticum chuanxiong in different proportions (0:1, 1:5, 2:5, 2:3, 1:1, 3:2, 5:2, 5:1, and 1:0) and at different concentrations on the peripheral blood index and the organ indices were observed. Then all indices were integrated to the total nourishing effect value by comprehensive index method. The interaction was analyzed by response surface method. The model parameters were estimated with nonlinear regression. The three-dimensional response surfaces were constructed with Matlab Software. RESULTS: In the response surface, most compatibility of Angelica sinensis and Ligusticum chuanxiong showed synergistic action, some showed addition action, and few of them showed obvious antagonist action. The proportion of Angelica sinensis and Ligusticum chuanxiong from 4:1 to 2:1 and the dose of Angelica sinensis and Ligusticum chuanxiong from low to high showed addition action, while the other proportions showed obvious addition action at low dose and synergistic action at high dose. CONCLUSIONS: The research results could provide scientific evidence for reasonable application of Angelica sinensis and Ligusticum chuanxiong in clinics of Chinese medicine. The quantitative analysis on drug interactions of herbal compatibility by response surface method could provide reference for relative studies. SN - 1003-5370 UR - https://www.unboundmedicine.com/medline/citation/23841275/[Research_on_nourishing_and_tonifying_blood_effects_of_the_herb_pair_consisting_of_Angelica_sinensis_and_Ligusticum_chuanxiong_on_the_basis_of_drug_interaction]_ DB - PRIME DP - Unbound Medicine ER -