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Diffusion tensor MRI of the corpus callosum in amyotrophic lateral sclerosis.
J Magn Reson Imaging. 2014 Mar; 39(3):641-7.JM

Abstract

PURPOSE

To determine if decline in corpus callosum (CC) white matter integrity in patients with amyotrophic lateral sclerosis (ALS) is localized to motor-related areas.

MATERIALS AND METHODS

Twenty-one ALS patients and 21 controls participated. Diffusion tensor images (DTI) were acquired using 3 Tesla (T) MRI. Tract-based spatial statistics were used to examine whole-brain white matter damage. A segmentation schema was used to define CC volumes-of-interest (VOI). Fractional anisotropy (FA) and radial- and axial-diffusivity (RD, AD) were extracted from VOIs and compared between groups. DTI measurements in motor-related Area III were tested for correlation with symptoms and disease duration.

RESULTS

Extracted FA values from CC VOIs were reduced in ALS patients (P≤0.0001), particularly in Areas II and III (P≤0.01). Reduced FA in Area III correlated with disease symptomology (P≤0.05) and duration (P≤0.02). Between-group whole-brain comparisons (P≤0.05, corrected) showed reduced FA and increased RD throughout white matter regions including the CC, corona radiata, and internal capsule. AD was increased in the left corona radiata and internal and external capsules.

CONCLUSION

FA in motor-related regions of the CC is more affected than other CC areas in ALS patients. Microstructural pathology of transcallosal fiber tracts may represent a future component of an imaging biomarker for ALS.

Authors+Show Affiliations

Medical School, University of Michigan, Ann Arbor, Michigan, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23843179

Citation

Chapman, Molly C., et al. "Diffusion Tensor MRI of the Corpus Callosum in Amyotrophic Lateral Sclerosis." Journal of Magnetic Resonance Imaging : JMRI, vol. 39, no. 3, 2014, pp. 641-7.
Chapman MC, Jelsone-Swain L, Johnson TD, et al. Diffusion tensor MRI of the corpus callosum in amyotrophic lateral sclerosis. J Magn Reson Imaging. 2014;39(3):641-7.
Chapman, M. C., Jelsone-Swain, L., Johnson, T. D., Gruis, K. L., & Welsh, R. C. (2014). Diffusion tensor MRI of the corpus callosum in amyotrophic lateral sclerosis. Journal of Magnetic Resonance Imaging : JMRI, 39(3), 641-7. https://doi.org/10.1002/jmri.24218
Chapman MC, et al. Diffusion Tensor MRI of the Corpus Callosum in Amyotrophic Lateral Sclerosis. J Magn Reson Imaging. 2014;39(3):641-7. PubMed PMID: 23843179.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diffusion tensor MRI of the corpus callosum in amyotrophic lateral sclerosis. AU - Chapman,Molly C, AU - Jelsone-Swain,Laura, AU - Johnson,Timothy D, AU - Gruis,Kirsten L, AU - Welsh,Robert C, Y1 - 2013/07/10/ PY - 2013/01/27/received PY - 2013/04/18/accepted PY - 2013/7/12/entrez PY - 2013/7/12/pubmed PY - 2015/1/22/medline KW - DTI KW - amyotrophic lateral sclerosis KW - corpus callosum SP - 641 EP - 7 JF - Journal of magnetic resonance imaging : JMRI JO - J Magn Reson Imaging VL - 39 IS - 3 N2 - PURPOSE: To determine if decline in corpus callosum (CC) white matter integrity in patients with amyotrophic lateral sclerosis (ALS) is localized to motor-related areas. MATERIALS AND METHODS: Twenty-one ALS patients and 21 controls participated. Diffusion tensor images (DTI) were acquired using 3 Tesla (T) MRI. Tract-based spatial statistics were used to examine whole-brain white matter damage. A segmentation schema was used to define CC volumes-of-interest (VOI). Fractional anisotropy (FA) and radial- and axial-diffusivity (RD, AD) were extracted from VOIs and compared between groups. DTI measurements in motor-related Area III were tested for correlation with symptoms and disease duration. RESULTS: Extracted FA values from CC VOIs were reduced in ALS patients (P≤0.0001), particularly in Areas II and III (P≤0.01). Reduced FA in Area III correlated with disease symptomology (P≤0.05) and duration (P≤0.02). Between-group whole-brain comparisons (P≤0.05, corrected) showed reduced FA and increased RD throughout white matter regions including the CC, corona radiata, and internal capsule. AD was increased in the left corona radiata and internal and external capsules. CONCLUSION: FA in motor-related regions of the CC is more affected than other CC areas in ALS patients. Microstructural pathology of transcallosal fiber tracts may represent a future component of an imaging biomarker for ALS. SN - 1522-2586 UR - https://www.unboundmedicine.com/medline/citation/23843179/Diffusion_tensor_MRI_of_the_corpus_callosum_in_amyotrophic_lateral_sclerosis_ L2 - https://doi.org/10.1002/jmri.24218 DB - PRIME DP - Unbound Medicine ER -