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Effect of dietary lipid structure in early postnatal life on mouse adipose tissue development and function in adulthood.

Abstract

Obese individuals have more (hyperplastic) and larger (hypertrophic) adipocytes in their white adipose tissue (WAT) than normal-weight individuals. The difference in cell number emerges early in childhood, suggesting that this is a critical period for being susceptible to obesity. Breast-feeding has been shown to be protective against obesity, and we have previously shown in mice that the physical structure of lipids in human milk may contribute to this protective effect. In the present study, we investigated how differences in the physical structure of lipids in the early diet may modulate adipose tissue development. Male mice were fed a diet containing control infant milk formula (Control IMF; Danone Research) or Nuturis® (Concept IMF with large phospholipid-coated lipid droplets; Danone Research) from postnatal day (PN)16 to 42. Subsequently, mice were challenged with a moderate Western-style diet (WSD) until PN98, and body composition was monitored by dual-energy X-ray absorptiometry. Epididymal WAT was analysed for adipocyte size, number and gene expression of metabolic transcription factors. Early Concept IMF exposure reduced fat accumulation during the WSD challenge by 30 % compared with the Control IMF. It reduced adipocyte size without affecting adipocyte number in adult mice. The Concept IMF decreased the expression of PPARγ, CCAAT/enhancer-binding protein and retinoid X receptor α in WAT in adulthood, key regulators of metabolic activity. In conclusion, Concept IMF exposure in early life reduced susceptibility to obesity in adult life, by preventing adipocyte hypertrophia upon adult dietary challenge without affecting adipogenesis. These data emphasise the importance of the physical properties of dietary lipids in early life in obesity risk later in life.

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  • Authors+Show Affiliations

    ,

    Danone Research - Centre for Specialised Nutrition, Bosrandweg 20, 6704 PH, Wageningen, The Netherlands.

    ,

    Division of Pharmacology, Department of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.

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    Danone Research - Centre for Specialised Nutrition, Bosrandweg 20, 6704 PH, Wageningen, The Netherlands.

    ,

    Danone Research - Centre for Specialised Nutrition, Bosrandweg 20, 6704 PH, Wageningen, The Netherlands.

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    Danone Research - Centre for Specialised Nutrition, Bosrandweg 20, 6704 PH, Wageningen, The Netherlands.

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    Danone Research - Centre for Specialised Nutrition, Bosrandweg 20, 6704 PH, Wageningen, The Netherlands.

    ,

    Department of Pediatric Gastroenterology and Hepatology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

    Danone Research - Centre for Specialised Nutrition, Singapore, Singapore.

    Source

    The British journal of nutrition 111:2 2014 Jan 28 pg 215-26

    MeSH

    Adipose Tissue
    Animal Feed
    Animals
    Diet
    Dietary Fats
    Epididymis
    Gene Expression Regulation
    Humans
    Infant
    Infant Formula
    Lipogenesis
    Male
    Mice
    Mice, Inbred C57BL
    Random Allocation

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    23845308

    Citation

    * When formatting your citation, note that all book, journal, and database titles should be italicized* Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of dietary lipid structure in early postnatal life on mouse adipose tissue development and function in adulthood. AU - Oosting,Annemarie, AU - van Vlies,Naomi, AU - Kegler,Diane, AU - Schipper,Lidewij, AU - Abrahamse-Berkeveld,Marieke, AU - Ringler,Silvia, AU - Verkade,Henkjan J, AU - van der Beek,Eline M, Y1 - 2013/07/11/ PY - 2013/7/13/entrez PY - 2013/7/13/pubmed PY - 2014/3/22/medline SP - 215 EP - 26 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 111 IS - 2 N2 - Obese individuals have more (hyperplastic) and larger (hypertrophic) adipocytes in their white adipose tissue (WAT) than normal-weight individuals. The difference in cell number emerges early in childhood, suggesting that this is a critical period for being susceptible to obesity. Breast-feeding has been shown to be protective against obesity, and we have previously shown in mice that the physical structure of lipids in human milk may contribute to this protective effect. In the present study, we investigated how differences in the physical structure of lipids in the early diet may modulate adipose tissue development. Male mice were fed a diet containing control infant milk formula (Control IMF; Danone Research) or Nuturis® (Concept IMF with large phospholipid-coated lipid droplets; Danone Research) from postnatal day (PN)16 to 42. Subsequently, mice were challenged with a moderate Western-style diet (WSD) until PN98, and body composition was monitored by dual-energy X-ray absorptiometry. Epididymal WAT was analysed for adipocyte size, number and gene expression of metabolic transcription factors. Early Concept IMF exposure reduced fat accumulation during the WSD challenge by 30 % compared with the Control IMF. It reduced adipocyte size without affecting adipocyte number in adult mice. The Concept IMF decreased the expression of PPARγ, CCAAT/enhancer-binding protein and retinoid X receptor α in WAT in adulthood, key regulators of metabolic activity. In conclusion, Concept IMF exposure in early life reduced susceptibility to obesity in adult life, by preventing adipocyte hypertrophia upon adult dietary challenge without affecting adipogenesis. These data emphasise the importance of the physical properties of dietary lipids in early life in obesity risk later in life. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/23845308/Effect_of_dietary_lipid_structure_in_early_postnatal_life_on_mouse_adipose_tissue_development_and_function_in_adulthood_ L2 - https://www.cambridge.org/core/product/identifier/S0007114513002201/type/journal_article DB - PRIME DP - Unbound Medicine ER -