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Glossina fuscipes populations provide insights for human African trypanosomiasis transmission in Uganda.
Trends Parasitol. 2013 Aug; 29(8):394-406.TP

Abstract

Uganda has both forms of human African trypanosomiasis (HAT): the chronic gambiense disease in the northwest and the acute rhodesiense disease in the south. The recent spread of rhodesiense into central Uganda has raised concerns given the different control strategies the two diseases require. We present knowledge on the population genetics of the major vector species Glossina fuscipes fuscipes in Uganda with a focus on population structure, measures of gene flow between populations, and the occurrence of polyandry. The microbiome composition and diversity is discussed, focusing on their potential role on trypanosome infection outcomes. We discuss the implications of these findings for large-scale tsetse control programs, including suppression or eradication, being undertaken in Uganda, and potential future genetic applications.

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Authors+Show Affiliations

Aksoy S
Yale School of Public Health, Department of Epidemiology of Microbial Diseases, Yale University, 60 College Street, New Haven, CT, USA. serap.aksoy@yale.edu
Caccone A
No affiliation info available
Galvani AP
No affiliation info available
Okedi LM
No affiliation info available

MeSH

AnimalsBiodiversityDNA, MitochondrialFemaleGene FlowGenetics, PopulationHost-Pathogen InteractionsHumansInsect VectorsMaleMicrobiotaMicrosatellite RepeatsPest Control, BiologicalSymbiosisTrypanosoma brucei gambienseTrypanosoma brucei rhodesienseTrypanosomiasis, AfricanTsetse FliesUganda

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

23845311

Citation

Aksoy, Serap, et al. "Glossina Fuscipes Populations Provide Insights for Human African Trypanosomiasis Transmission in Uganda." Trends in Parasitology, vol. 29, no. 8, 2013, pp. 394-406.
Aksoy S, Caccone A, Galvani AP, et al. Glossina fuscipes populations provide insights for human African trypanosomiasis transmission in Uganda. Trends Parasitol. 2013;29(8):394-406.
Aksoy, S., Caccone, A., Galvani, A. P., & Okedi, L. M. (2013). Glossina fuscipes populations provide insights for human African trypanosomiasis transmission in Uganda. Trends in Parasitology, 29(8), 394-406. https://doi.org/10.1016/j.pt.2013.06.005
Aksoy S, et al. Glossina Fuscipes Populations Provide Insights for Human African Trypanosomiasis Transmission in Uganda. Trends Parasitol. 2013;29(8):394-406. PubMed PMID: 23845311.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glossina fuscipes populations provide insights for human African trypanosomiasis transmission in Uganda. AU - Aksoy,Serap, AU - Caccone,Adalgisa, AU - Galvani,Alison P, AU - Okedi,Loyce M, Y1 - 2013/07/08/ PY - 2013/05/03/received PY - 2013/06/11/revised PY - 2013/06/11/accepted PY - 2013/7/13/entrez PY - 2013/7/13/pubmed PY - 2014/1/28/medline KW - Glossina fuscipes KW - Trypanosoma brucei gambiense KW - Trypanosoma brucei rhodesiense KW - Uganda KW - human African trypanosomiasis KW - population genetics KW - sleeping sickness KW - vector control SP - 394 EP - 406 JF - Trends in parasitology JO - Trends Parasitol VL - 29 IS - 8 N2 - Uganda has both forms of human African trypanosomiasis (HAT): the chronic gambiense disease in the northwest and the acute rhodesiense disease in the south. The recent spread of rhodesiense into central Uganda has raised concerns given the different control strategies the two diseases require. We present knowledge on the population genetics of the major vector species Glossina fuscipes fuscipes in Uganda with a focus on population structure, measures of gene flow between populations, and the occurrence of polyandry. The microbiome composition and diversity is discussed, focusing on their potential role on trypanosome infection outcomes. We discuss the implications of these findings for large-scale tsetse control programs, including suppression or eradication, being undertaken in Uganda, and potential future genetic applications. SN - 1471-5007 UR - https://www.unboundmedicine.com/medline/citation/23845311/Glossina_fuscipes_populations_provide_insights_for_human_African_trypanosomiasis_transmission_in_Uganda_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1471-4922(13)00105-0 DB - PRIME DP - Unbound Medicine ER -