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Excitability modulation of the motor system induced by transcranial direct current stimulation: a multimodal approach.
Neuroimage 2013; 83:569-80N

Abstract

Anodal and cathodal transcranial direct current stimulations (tDCS) are both established techniques to induce cortical excitability changes. Typically, in the human motor system, such cortical modulations are inferred through changes in the amplitude of the motor evoked potentials (MEPs). However, it is now possible to directly evaluate tDCS-induced changes at the cortical level by recording the transcranial magnetic stimulation evoked potentials (TEPs) using electroencephalography (EEG). The present study investigated the modulation induced by the tDCS on the motor system. The study evaluates changes in the MEPs, in the amplitude and distribution of the TEPs, in resting state oscillatory brain activity and in behavioral performance in a simple manual response task. Both the short- and long-term tDCS effects were investigated by evaluating their time course at ~0 and 30min after tDCS. Anodal tDCS over the left primary motor cortex (M1) induced an enhancement of corticospinal excitability, whereas cathodal stimulation produced a reduction. These changes in excitability were indexed by changes in MEP amplitude. More interestingly, tDCS modulated the cortical reactivity, which is the neuronal activity evoked by TMS, in a polarity-dependent and site-specific manner. Cortical reactivity increased after anodal stimulation over the left M1, whereas it decreased with cathodal stimulation. These effects were partially present also at long term evaluation. No polarity-specific effect was found either on behavioral measures or on oscillatory brain activity. The latter showed a general increase in the power density of low frequency oscillations (theta and alpha) at both stimulation polarities. Our results suggest that tDCS is able to modulate motor cortical reactivity in a polarity-specific manner, inducing a complex pattern of direct and indirect cortical activations or inhibitions of the motor system-related network, which might be related to changes in synaptic efficacy of the motor cortex.

Authors+Show Affiliations

Cognitive Neuroscience Section, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23845429

Citation

Pellicciari, Maria Concetta, et al. "Excitability Modulation of the Motor System Induced By Transcranial Direct Current Stimulation: a Multimodal Approach." NeuroImage, vol. 83, 2013, pp. 569-80.
Pellicciari MC, Brignani D, Miniussi C. Excitability modulation of the motor system induced by transcranial direct current stimulation: a multimodal approach. Neuroimage. 2013;83:569-80.
Pellicciari, M. C., Brignani, D., & Miniussi, C. (2013). Excitability modulation of the motor system induced by transcranial direct current stimulation: a multimodal approach. NeuroImage, 83, pp. 569-80. doi:10.1016/j.neuroimage.2013.06.076.
Pellicciari MC, Brignani D, Miniussi C. Excitability Modulation of the Motor System Induced By Transcranial Direct Current Stimulation: a Multimodal Approach. Neuroimage. 2013;83:569-80. PubMed PMID: 23845429.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Excitability modulation of the motor system induced by transcranial direct current stimulation: a multimodal approach. AU - Pellicciari,Maria Concetta, AU - Brignani,Debora, AU - Miniussi,Carlo, Y1 - 2013/07/09/ PY - 2013/04/23/received PY - 2013/06/12/revised PY - 2013/06/29/accepted PY - 2013/7/13/entrez PY - 2013/7/13/pubmed PY - 2014/6/26/medline KW - Cortical reactivity KW - EEG KW - LMFP KW - Motor cortex KW - Reaction time KW - TEP KW - TMS KW - local mean field power KW - tDCS KW - transcranial direct current stimulation KW - transcranial magnetic stimulation evoked potential SP - 569 EP - 80 JF - NeuroImage JO - Neuroimage VL - 83 N2 - Anodal and cathodal transcranial direct current stimulations (tDCS) are both established techniques to induce cortical excitability changes. Typically, in the human motor system, such cortical modulations are inferred through changes in the amplitude of the motor evoked potentials (MEPs). However, it is now possible to directly evaluate tDCS-induced changes at the cortical level by recording the transcranial magnetic stimulation evoked potentials (TEPs) using electroencephalography (EEG). The present study investigated the modulation induced by the tDCS on the motor system. The study evaluates changes in the MEPs, in the amplitude and distribution of the TEPs, in resting state oscillatory brain activity and in behavioral performance in a simple manual response task. Both the short- and long-term tDCS effects were investigated by evaluating their time course at ~0 and 30min after tDCS. Anodal tDCS over the left primary motor cortex (M1) induced an enhancement of corticospinal excitability, whereas cathodal stimulation produced a reduction. These changes in excitability were indexed by changes in MEP amplitude. More interestingly, tDCS modulated the cortical reactivity, which is the neuronal activity evoked by TMS, in a polarity-dependent and site-specific manner. Cortical reactivity increased after anodal stimulation over the left M1, whereas it decreased with cathodal stimulation. These effects were partially present also at long term evaluation. No polarity-specific effect was found either on behavioral measures or on oscillatory brain activity. The latter showed a general increase in the power density of low frequency oscillations (theta and alpha) at both stimulation polarities. Our results suggest that tDCS is able to modulate motor cortical reactivity in a polarity-specific manner, inducing a complex pattern of direct and indirect cortical activations or inhibitions of the motor system-related network, which might be related to changes in synaptic efficacy of the motor cortex. SN - 1095-9572 UR - https://www.unboundmedicine.com/medline/citation/23845429/Excitability_modulation_of_the_motor_system_induced_by_transcranial_direct_current_stimulation:_a_multimodal_approach_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1053-8119(13)00719-2 DB - PRIME DP - Unbound Medicine ER -