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An updated meta-analysis of endothelial nitric oxide synthase gene: three well-characterized polymorphisms with ischemic stroke.
Gene. 2013 Oct 10; 528(2):84-92.GENE

Abstract

Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene may influence the risk of ischemic stroke (IS), but the results are still debatable. A meta-analysis was performed to investigate the association between the eNOS gene polymorphisms in IS risk. Case-control studies on the association between the G894T, T-786C, and 4b/a polymorphisms and IS were searched up to July 2012, and the genotype frequencies in the control group were found to be consistent with the Hardy-Weinberg equilibrium (HWE). The effect summary odds ratio (OR) and 95% confidence intervals (CIs) were obtained. Meta-regression was used to explore the potential sources of heterogeneity. Funnel plots and Egger's test was used to estimate small study biases, and heterogeneity was assessed by chi-square-based Q-test and I(2) test. There were total 6537/6475 cases/controls for G894T, 3459/3951 cases/controls for 4b/a, and 2125/2673 cases/controls for T-786C polymorphism. For G894T and 4b/a, a significant association of 894T allele and 4a allele with increased risk of IS was found in Asians (TT+GT vs. GG: p<0.00001, OR=1.60, 95% CI=1.38-1.79, Pheterogeneity=0.11; aa+ba vs. bb: P<0.00001, OR=1.60, 95% CI=1.30-1.97, Pheterogeneity=0.02), but not in Caucasians (TT+GT vs. GG: P=0.60, OR=0.94, 95% CI=0.75-1.19, Pheterogeneity=0.002; aa+ba vs. bb: P=0.13, OR=0.81, 95% CI=0.62-1.06, Pheterogeneity=0.63). For T-786C polymorphism, there were no significant differences in genotype distribution between IS and control in Asians (CC+TC vs. TT: P=0.15, OR=1.14, 95% CI=0.95-1.37, Pheterogeneity=0.94) and in Caucasians (CC+TC vs. TT: P=0.72, OR=0.96, 95% CI=0.75-1.22, Pheterogeneity=0.53). This analysis provides strong evidence that the eNOS T-786C gene polymorphism is not associated with IS, the G894T and 4b/a polymorphisms might be associated with IS, at least in Asians.

Authors+Show Affiliations

Department of Preventive Medicine, Wannan Medical College, 241002 Wuhu, Anhui, China. yingshuiyao@163.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23845784

Citation

Yao, Ying-Shui, et al. "An Updated Meta-analysis of Endothelial Nitric Oxide Synthase Gene: Three Well-characterized Polymorphisms With Ischemic Stroke." Gene, vol. 528, no. 2, 2013, pp. 84-92.
Yao YS, Chang WW, Jin YL, et al. An updated meta-analysis of endothelial nitric oxide synthase gene: three well-characterized polymorphisms with ischemic stroke. Gene. 2013;528(2):84-92.
Yao, Y. S., Chang, W. W., Jin, Y. L., & He, L. P. (2013). An updated meta-analysis of endothelial nitric oxide synthase gene: three well-characterized polymorphisms with ischemic stroke. Gene, 528(2), 84-92. https://doi.org/10.1016/j.gene.2013.06.047
Yao YS, et al. An Updated Meta-analysis of Endothelial Nitric Oxide Synthase Gene: Three Well-characterized Polymorphisms With Ischemic Stroke. Gene. 2013 Oct 10;528(2):84-92. PubMed PMID: 23845784.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An updated meta-analysis of endothelial nitric oxide synthase gene: three well-characterized polymorphisms with ischemic stroke. AU - Yao,Ying-Shui, AU - Chang,Wei-Wei, AU - Jin,Yue-Long, AU - He,Lian-Ping, Y1 - 2013/07/09/ PY - 2013/01/17/received PY - 2013/05/28/revised PY - 2013/06/17/accepted PY - 2013/7/13/entrez PY - 2013/7/13/pubmed PY - 2013/11/6/medline KW - CI KW - Endothelial nitric oxide synthase KW - Gene KW - HWE KW - Hardy–Weinberg equilibrium KW - IS KW - Ischemic stroke KW - Meta-analysis KW - NO KW - OR KW - Polymorphism KW - confidence interval KW - eNOS KW - endothelial nitric oxide synthase KW - ischemic stroke KW - nitric oxide KW - odds ratio SP - 84 EP - 92 JF - Gene JO - Gene VL - 528 IS - 2 N2 - Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene may influence the risk of ischemic stroke (IS), but the results are still debatable. A meta-analysis was performed to investigate the association between the eNOS gene polymorphisms in IS risk. Case-control studies on the association between the G894T, T-786C, and 4b/a polymorphisms and IS were searched up to July 2012, and the genotype frequencies in the control group were found to be consistent with the Hardy-Weinberg equilibrium (HWE). The effect summary odds ratio (OR) and 95% confidence intervals (CIs) were obtained. Meta-regression was used to explore the potential sources of heterogeneity. Funnel plots and Egger's test was used to estimate small study biases, and heterogeneity was assessed by chi-square-based Q-test and I(2) test. There were total 6537/6475 cases/controls for G894T, 3459/3951 cases/controls for 4b/a, and 2125/2673 cases/controls for T-786C polymorphism. For G894T and 4b/a, a significant association of 894T allele and 4a allele with increased risk of IS was found in Asians (TT+GT vs. GG: p<0.00001, OR=1.60, 95% CI=1.38-1.79, Pheterogeneity=0.11; aa+ba vs. bb: P<0.00001, OR=1.60, 95% CI=1.30-1.97, Pheterogeneity=0.02), but not in Caucasians (TT+GT vs. GG: P=0.60, OR=0.94, 95% CI=0.75-1.19, Pheterogeneity=0.002; aa+ba vs. bb: P=0.13, OR=0.81, 95% CI=0.62-1.06, Pheterogeneity=0.63). For T-786C polymorphism, there were no significant differences in genotype distribution between IS and control in Asians (CC+TC vs. TT: P=0.15, OR=1.14, 95% CI=0.95-1.37, Pheterogeneity=0.94) and in Caucasians (CC+TC vs. TT: P=0.72, OR=0.96, 95% CI=0.75-1.22, Pheterogeneity=0.53). This analysis provides strong evidence that the eNOS T-786C gene polymorphism is not associated with IS, the G894T and 4b/a polymorphisms might be associated with IS, at least in Asians. SN - 1879-0038 UR - https://www.unboundmedicine.com/medline/citation/23845784/An_updated_meta_analysis_of_endothelial_nitric_oxide_synthase_gene:_three_well_characterized_polymorphisms_with_ischemic_stroke_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-1119(13)00804-4 DB - PRIME DP - Unbound Medicine ER -