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Calcitonin gene-related peptide (CGRP) and migraine current understanding and state of development.
Headache. 2013 Sep; 53(8):1230-44.H

Abstract

Calcitonin gene-related peptide (CGRP) is a ubiquitous neuropeptide found at the very centers of the migraine process, both centrally and peripherally. It has been under careful study for approximately 25 years. Several CGRP-receptor antagonists are being evaluated for acute treatment of episodic migraine. Three monoclonal antibodies are being studied for prevention of episodic migraine, and 1 monoclonal antibody is being studied for prevention of chronic migraine. In this review, we discuss the role of CGRP in normal physiology and the consequences of CGRP inhibition for human homeostasis. We then review the current state of development for CGRP-receptor antagonists and CGRP monoclonal antibodies. We close by speculating on the potential clinical role of CGRP antagonism in the acute and preventive treatment of episodic and chronic migraine.

Authors+Show Affiliations

Labrys Biologics, Inc, San Mateo, CA, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23848260

Citation

Bigal, Marcelo E., et al. "Calcitonin Gene-related Peptide (CGRP) and Migraine Current Understanding and State of Development." Headache, vol. 53, no. 8, 2013, pp. 1230-44.
Bigal ME, Walter S, Rapoport AM. Calcitonin gene-related peptide (CGRP) and migraine current understanding and state of development. Headache. 2013;53(8):1230-44.
Bigal, M. E., Walter, S., & Rapoport, A. M. (2013). Calcitonin gene-related peptide (CGRP) and migraine current understanding and state of development. Headache, 53(8), 1230-44. https://doi.org/10.1111/head.12179
Bigal ME, Walter S, Rapoport AM. Calcitonin Gene-related Peptide (CGRP) and Migraine Current Understanding and State of Development. Headache. 2013;53(8):1230-44. PubMed PMID: 23848260.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Calcitonin gene-related peptide (CGRP) and migraine current understanding and state of development. AU - Bigal,Marcelo E, AU - Walter,Sarah, AU - Rapoport,Alan M, Y1 - 2013/07/12/ PY - 2013/06/07/accepted PY - 2013/7/16/entrez PY - 2013/7/16/pubmed PY - 2014/7/16/medline KW - antibodies KW - calcitonin gene-related peptide KW - chronic migraine KW - migraine SP - 1230 EP - 44 JF - Headache JO - Headache VL - 53 IS - 8 N2 - Calcitonin gene-related peptide (CGRP) is a ubiquitous neuropeptide found at the very centers of the migraine process, both centrally and peripherally. It has been under careful study for approximately 25 years. Several CGRP-receptor antagonists are being evaluated for acute treatment of episodic migraine. Three monoclonal antibodies are being studied for prevention of episodic migraine, and 1 monoclonal antibody is being studied for prevention of chronic migraine. In this review, we discuss the role of CGRP in normal physiology and the consequences of CGRP inhibition for human homeostasis. We then review the current state of development for CGRP-receptor antagonists and CGRP monoclonal antibodies. We close by speculating on the potential clinical role of CGRP antagonism in the acute and preventive treatment of episodic and chronic migraine. SN - 1526-4610 UR - https://www.unboundmedicine.com/medline/citation/23848260/Calcitonin_gene_related_peptide__CGRP__and_migraine_current_understanding_and_state_of_development_ L2 - https://doi.org/10.1111/head.12179 DB - PRIME DP - Unbound Medicine ER -