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Association between visual parameters and neuroimaging features of idiopathic intracranial hypertension.
J Neurol Sci. 2013 Sep 15; 332(1-2):80-5.JN

Abstract

BACKGROUND/AIMS

Papilledema refers to optic disc swelling resulting from high intracranial pressure (ICP). The precise mechanism by which papilledema occurs remains uncertain. Although orbital neuroimaging features associated with papilledema are well-described, it is unclear whether these findings correlate with visual function. Idiopathic Intracranial Hypertension (IIH) is a condition in which the intracranial pressure is elevated with no obvious cause, causing papilledema and visual loss. The utility of papilledema and IIH neuroimaging findings as a surrogate marker for visual loss, or a predictor of visual loss, is understudied. This retrospective cross-sectional review aims to correlate parameters of visual function with orbital magnetic resonance imaging (MRI) findings.

METHODS

Patients meeting criteria for IIH who had received orbital imaging within 4 weeks of examination were included. Visual parameters of papilledema grade, visual field mean deviation, and visual acuity were correlated with neuroimaging features, including optic nerve thickness, and optic nerve sheath thickness, among others. All MRI scans were reviewed by a neuroradiologist blinded to clinical status. Spearman rank correlations and t-tests were generated with SAS (v9.2).

RESULTS

Thirty five patients were included. No significant relationships were found between the main visual parameters of papilledema grade and visual field mean deviation, and MRI findings.

CONCLUSIONS

We found no significant correlation between visual parameters and imaging features of papilledema. This might indicate that MRI features may provide insight into the structural changes that occur in papilledema, but may not be helpful when making clinical management decisions for patients with IIH in particular, and papilledema in general.

Authors+Show Affiliations

School of Medicine, Washington University in St. Louis, MO 63108, United States.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23850064

Citation

Padhye, Leena V., et al. "Association Between Visual Parameters and Neuroimaging Features of Idiopathic Intracranial Hypertension." Journal of the Neurological Sciences, vol. 332, no. 1-2, 2013, pp. 80-5.
Padhye LV, Van Stavern GP, Sharma A, et al. Association between visual parameters and neuroimaging features of idiopathic intracranial hypertension. J Neurol Sci. 2013;332(1-2):80-5.
Padhye, L. V., Van Stavern, G. P., Sharma, A., Viets, R., Huecker, J. B., & Gordon, M. O. (2013). Association between visual parameters and neuroimaging features of idiopathic intracranial hypertension. Journal of the Neurological Sciences, 332(1-2), 80-5. https://doi.org/10.1016/j.jns.2013.06.022
Padhye LV, et al. Association Between Visual Parameters and Neuroimaging Features of Idiopathic Intracranial Hypertension. J Neurol Sci. 2013 Sep 15;332(1-2):80-5. PubMed PMID: 23850064.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between visual parameters and neuroimaging features of idiopathic intracranial hypertension. AU - Padhye,Leena V, AU - Van Stavern,Gregory P, AU - Sharma,Aseem, AU - Viets,Ryan, AU - Huecker,Julie B, AU - Gordon,Mae O, Y1 - 2013/07/11/ PY - 2013/03/01/received PY - 2013/06/13/revised PY - 2013/06/19/accepted PY - 2013/7/16/entrez PY - 2013/7/16/pubmed PY - 2014/3/14/medline KW - Idiopathic intracranial hypertension KW - Neuroimaging KW - Optic neuropathy KW - Orbital imaging KW - Papilledema KW - Pseudotumor cerebri SP - 80 EP - 5 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 332 IS - 1-2 N2 - BACKGROUND/AIMS: Papilledema refers to optic disc swelling resulting from high intracranial pressure (ICP). The precise mechanism by which papilledema occurs remains uncertain. Although orbital neuroimaging features associated with papilledema are well-described, it is unclear whether these findings correlate with visual function. Idiopathic Intracranial Hypertension (IIH) is a condition in which the intracranial pressure is elevated with no obvious cause, causing papilledema and visual loss. The utility of papilledema and IIH neuroimaging findings as a surrogate marker for visual loss, or a predictor of visual loss, is understudied. This retrospective cross-sectional review aims to correlate parameters of visual function with orbital magnetic resonance imaging (MRI) findings. METHODS: Patients meeting criteria for IIH who had received orbital imaging within 4 weeks of examination were included. Visual parameters of papilledema grade, visual field mean deviation, and visual acuity were correlated with neuroimaging features, including optic nerve thickness, and optic nerve sheath thickness, among others. All MRI scans were reviewed by a neuroradiologist blinded to clinical status. Spearman rank correlations and t-tests were generated with SAS (v9.2). RESULTS: Thirty five patients were included. No significant relationships were found between the main visual parameters of papilledema grade and visual field mean deviation, and MRI findings. CONCLUSIONS: We found no significant correlation between visual parameters and imaging features of papilledema. This might indicate that MRI features may provide insight into the structural changes that occur in papilledema, but may not be helpful when making clinical management decisions for patients with IIH in particular, and papilledema in general. SN - 1878-5883 UR - https://www.unboundmedicine.com/medline/citation/23850064/Association_between_visual_parameters_and_neuroimaging_features_of_idiopathic_intracranial_hypertension_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(13)00284-0 DB - PRIME DP - Unbound Medicine ER -