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The relationship between lower urinary tract symptoms/benign prostatic hyperplasia and the number of components of metabolic syndrome.
Urology. 2013 Sep; 82(3):674-9.U

Abstract

OBJECTIVE

To investigate the relationship between lower urinary tract symptoms (LUTS)/benign prostate hyperplasia (BPH) and a number of components of metabolic syndrome (MetS).

METHODS

A total of 1224 male police officers aged 50-59 years who had participated in a health examination were included. LUTS/BPH were assessed by prostate-specific antigen, international prostate symptom score (IPSS), total prostate volume (TPV), maximum urinary flow rate (Qmax), and postvoid residual (PVR) urine volume. Testosterone levels were also examined. MetS was defined using National Cholesterol Education Program-Adult Treatment Panel III guidelines. The subjects were classified into 4 groups according to the number of exhibited MetS components (0, 1-2, 3, and 4-5). We used the Mantel-Haenszel extension test and logistic regression analyses.

RESULTS

MetS was diagnosed in 29.0% of the patients. The BPH ratio (IPSS >7, TPV ≥30 mL, and/or Qmax <15 mL/sec), TPV ≥30 mL, and PVR ≥50 mL significantly increased with an increasing number of metabolic abnormalities. The odds ratio (OR) in relation to a TPV ≥30 mL and a PVR ≥50 mL significantly rose as the number of positive MetS components increased after adjusting for age and testosterone. Additionally, the ORs (adjusting for age and testosterone) in relation to BPH also increased as the number of positive MetS components increased, with a suggestive threshold effect associated with 4-5 positive components (BPH: IPSS >7 + TPV ≥30 mL; 4 and 5 components, 3.496, 1.805-6.769, P = .001; BPH: IPSS >7 + TPV ≥30 mL + Qmax <15 mL/sec; 4 and 5 components, 5.458, 1.777-16.764, P = .002).

CONCLUSION

According to our results, the cases of LUTS/BPH were positively associated with the number of MetS components.

Authors+Show Affiliations

Department of Urology, National Police Hospital, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23850334

Citation

Park, Yeon Won, et al. "The Relationship Between Lower Urinary Tract Symptoms/benign Prostatic Hyperplasia and the Number of Components of Metabolic Syndrome." Urology, vol. 82, no. 3, 2013, pp. 674-9.
Park YW, Kim SB, Kwon H, et al. The relationship between lower urinary tract symptoms/benign prostatic hyperplasia and the number of components of metabolic syndrome. Urology. 2013;82(3):674-9.
Park, Y. W., Kim, S. B., Kwon, H., Kang, H. C., Cho, K., Lee, K. I., Kim, Y. J., & Lee, J. H. (2013). The relationship between lower urinary tract symptoms/benign prostatic hyperplasia and the number of components of metabolic syndrome. Urology, 82(3), 674-9. https://doi.org/10.1016/j.urology.2013.03.047
Park YW, et al. The Relationship Between Lower Urinary Tract Symptoms/benign Prostatic Hyperplasia and the Number of Components of Metabolic Syndrome. Urology. 2013;82(3):674-9. PubMed PMID: 23850334.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship between lower urinary tract symptoms/benign prostatic hyperplasia and the number of components of metabolic syndrome. AU - Park,Yeon Won, AU - Kim,Sung Bin, AU - Kwon,Hanna, AU - Kang,Hee Cheol, AU - Cho,Kyunghee, AU - Lee,Kung In, AU - Kim,Yung Jung, AU - Lee,Jun Ho, Y1 - 2013/07/11/ PY - 2013/01/20/received PY - 2013/03/14/revised PY - 2013/03/22/accepted PY - 2013/7/16/entrez PY - 2013/7/16/pubmed PY - 2013/12/18/medline SP - 674 EP - 9 JF - Urology JO - Urology VL - 82 IS - 3 N2 - OBJECTIVE: To investigate the relationship between lower urinary tract symptoms (LUTS)/benign prostate hyperplasia (BPH) and a number of components of metabolic syndrome (MetS). METHODS: A total of 1224 male police officers aged 50-59 years who had participated in a health examination were included. LUTS/BPH were assessed by prostate-specific antigen, international prostate symptom score (IPSS), total prostate volume (TPV), maximum urinary flow rate (Qmax), and postvoid residual (PVR) urine volume. Testosterone levels were also examined. MetS was defined using National Cholesterol Education Program-Adult Treatment Panel III guidelines. The subjects were classified into 4 groups according to the number of exhibited MetS components (0, 1-2, 3, and 4-5). We used the Mantel-Haenszel extension test and logistic regression analyses. RESULTS: MetS was diagnosed in 29.0% of the patients. The BPH ratio (IPSS >7, TPV ≥30 mL, and/or Qmax <15 mL/sec), TPV ≥30 mL, and PVR ≥50 mL significantly increased with an increasing number of metabolic abnormalities. The odds ratio (OR) in relation to a TPV ≥30 mL and a PVR ≥50 mL significantly rose as the number of positive MetS components increased after adjusting for age and testosterone. Additionally, the ORs (adjusting for age and testosterone) in relation to BPH also increased as the number of positive MetS components increased, with a suggestive threshold effect associated with 4-5 positive components (BPH: IPSS >7 + TPV ≥30 mL; 4 and 5 components, 3.496, 1.805-6.769, P = .001; BPH: IPSS >7 + TPV ≥30 mL + Qmax <15 mL/sec; 4 and 5 components, 5.458, 1.777-16.764, P = .002). CONCLUSION: According to our results, the cases of LUTS/BPH were positively associated with the number of MetS components. SN - 1527-9995 UR - https://www.unboundmedicine.com/medline/citation/23850334/The_relationship_between_lower_urinary_tract_symptoms/benign_prostatic_hyperplasia_and_the_number_of_components_of_metabolic_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-4295(13)00422-6 DB - PRIME DP - Unbound Medicine ER -