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Simultaneous electrochemical detection of ascorbic acid, dopamine and uric acid based on graphene anchored with Pd-Pt nanoparticles.
Colloids Surf B Biointerfaces. 2013 Nov 01; 111:392-7.CS

Abstract

Pd-Pt bimetallic nanoparticles anchored on functionalized reduced graphene oxide (RGO) nanomaterials were synthesized via a one-step in situ reduction process, in which Pt and Pd ions were first attached to poly(diallyldimethylammonium chloride) (PDDA) functionalized graphene oxide (GO) sheets, and then the encased metal ions and GO were subjected to simultaneous reduction by ethylene glycol. The as-prepared Pd3Pt1/PDDA-RGO nanocomposites were characterized by transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), Raman spectroscopy and electrochemical methods. In addition, an electrochemical sensor based on the graphene nanocomposites was fabricated for the simultaneous detection of ascorbic acid (AA), dopamine (DA) and uric acid (UA) in their ternary mixture. Three well-separated voltammetric peaks along with remarkable increasing electro-oxidation currents were obtained in differential pulse voltammetry (DPV) measurements. Under the optimized conditions, there were linear relationships between the peak currents and the concentrations in the range of 40-1200 μM for AA, 4-200 μM for DA and 4-400 μM for UA, with the limit of detection (LOD) (based on S/N=3) of 0.61, 0.04 and 0.10 μM for AA, DA and UA, respectively. This improved electrochemical performance can be attributed to the synergistic effect of metallic nanoparticles and RGO and the combination of the bimetallic nanoparticles. Furthermore, the practical electroanalytical utility of the sensor was demonstrated by the determination of AA, DA and together with UA in human urine and blood serum samples with satisfactory results.

Authors+Show Affiliations

School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.School of Pharmacy, Nanjing Medical University, Nanjing 211166, China. Electronic address: huijun_jiang2006@hotmail.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23850748

Citation

Yan, Jun, et al. "Simultaneous Electrochemical Detection of Ascorbic Acid, Dopamine and Uric Acid Based On Graphene Anchored With Pd-Pt Nanoparticles." Colloids and Surfaces. B, Biointerfaces, vol. 111, 2013, pp. 392-7.
Yan J, Liu S, Zhang Z, et al. Simultaneous electrochemical detection of ascorbic acid, dopamine and uric acid based on graphene anchored with Pd-Pt nanoparticles. Colloids Surf B Biointerfaces. 2013;111:392-7.
Yan, J., Liu, S., Zhang, Z., He, G., Zhou, P., Liang, H., Tian, L., Zhou, X., & Jiang, H. (2013). Simultaneous electrochemical detection of ascorbic acid, dopamine and uric acid based on graphene anchored with Pd-Pt nanoparticles. Colloids and Surfaces. B, Biointerfaces, 111, 392-7. https://doi.org/10.1016/j.colsurfb.2013.06.030
Yan J, et al. Simultaneous Electrochemical Detection of Ascorbic Acid, Dopamine and Uric Acid Based On Graphene Anchored With Pd-Pt Nanoparticles. Colloids Surf B Biointerfaces. 2013 Nov 1;111:392-7. PubMed PMID: 23850748.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simultaneous electrochemical detection of ascorbic acid, dopamine and uric acid based on graphene anchored with Pd-Pt nanoparticles. AU - Yan,Jun, AU - Liu,Shi, AU - Zhang,Zhenqin, AU - He,Guangwu, AU - Zhou,Ping, AU - Liang,Haiying, AU - Tian,Lulu, AU - Zhou,Xuemin, AU - Jiang,Huijun, Y1 - 2013/06/21/ PY - 2013/03/18/received PY - 2013/06/08/revised PY - 2013/06/12/accepted PY - 2013/7/16/entrez PY - 2013/7/16/pubmed PY - 2015/7/3/medline KW - Ascorbic acid KW - Dopamine KW - Graphene KW - Pd–Pt bimetallic nanoparticles KW - Simultaneous detection KW - Uric acid SP - 392 EP - 7 JF - Colloids and surfaces. B, Biointerfaces JO - Colloids Surf B Biointerfaces VL - 111 N2 - Pd-Pt bimetallic nanoparticles anchored on functionalized reduced graphene oxide (RGO) nanomaterials were synthesized via a one-step in situ reduction process, in which Pt and Pd ions were first attached to poly(diallyldimethylammonium chloride) (PDDA) functionalized graphene oxide (GO) sheets, and then the encased metal ions and GO were subjected to simultaneous reduction by ethylene glycol. The as-prepared Pd3Pt1/PDDA-RGO nanocomposites were characterized by transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), Raman spectroscopy and electrochemical methods. In addition, an electrochemical sensor based on the graphene nanocomposites was fabricated for the simultaneous detection of ascorbic acid (AA), dopamine (DA) and uric acid (UA) in their ternary mixture. Three well-separated voltammetric peaks along with remarkable increasing electro-oxidation currents were obtained in differential pulse voltammetry (DPV) measurements. Under the optimized conditions, there were linear relationships between the peak currents and the concentrations in the range of 40-1200 μM for AA, 4-200 μM for DA and 4-400 μM for UA, with the limit of detection (LOD) (based on S/N=3) of 0.61, 0.04 and 0.10 μM for AA, DA and UA, respectively. This improved electrochemical performance can be attributed to the synergistic effect of metallic nanoparticles and RGO and the combination of the bimetallic nanoparticles. Furthermore, the practical electroanalytical utility of the sensor was demonstrated by the determination of AA, DA and together with UA in human urine and blood serum samples with satisfactory results. SN - 1873-4367 UR - https://www.unboundmedicine.com/medline/citation/23850748/Simultaneous_electrochemical_detection_of_ascorbic_acid_dopamine_and_uric_acid_based_on_graphene_anchored_with_Pd_Pt_nanoparticles_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0927-7765(13)00406-2 DB - PRIME DP - Unbound Medicine ER -