Tags

Type your tag names separated by a space and hit enter

Plasma vaspin concentrations are decreased in acute coronary syndrome, but unchanged in patients without coronary lesions.
Clin Biochem. 2013 Oct; 46(15):1520-5.CB

Abstract

OBJECTIVE

Previous studies suggested that decreased serum vaspin levels were associated with coronary artery disease (CAD). The present study aimed to investigate the association between plasma vaspin levels and different states of CAD.

DESIGN AND METHODS

A total of 162 patients with coronary angiography (CAG) proved that CAD was enrolled. Additional 103 patients complained with "chest discomfort" with negative CAG, and 60 normal subjects were enrolled in this study. The levels of plasma vaspin, adiponectin, clinical parameters, lipid profile and C reactive protein (CRP) were measured.

RESULTS

The levels of plasma vaspin were significantly lower in the CAD group (0.47±0.63 μg/L) than those in the healthy group and CAG (-) group (all p<0.001). In CAD group, the pos hoc analysis showed that serum vaspin concentration in acute myocardial infarction group (0.21±0.19 μg/L) was significantly lower than that in the unstable angina pectoris group (0.40±0.37 μg/L) (p=0.012), and serum vaspin concentration in unstable angina pectoris was significantly lower than that in stable angina pectoris group (0.92±0.94 μg/L) (p=0.013). The plasma vaspin concentration was also negatively correlated with the severity of CAD (1-vessel: 0.86±0.90 μg/L; 2-vessel: 0.36±0.39 μg/L; 3-vessel: 0.21±0.16 μg/L). The plasma vaspin concentration in CAG (-) group with "chest discomfort" (1.93±2.57 μg/L) was similar to the healthy control group (2.18±3.49μg/L).

CONCLUSIONS

The plasma vaspin concentration correlated to the severity of CAD. Furthermore, plasma vaspin has a value of avoiding patients without CAD from unnecessary CAG.

Authors+Show Affiliations

Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China; Department of Cardiology, Department of Medicine, The Affiliated People's Hospital of Jiangsu University, Zhenjiang, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23850850

Citation

Zhang, Baowei, et al. "Plasma Vaspin Concentrations Are Decreased in Acute Coronary Syndrome, but Unchanged in Patients Without Coronary Lesions." Clinical Biochemistry, vol. 46, no. 15, 2013, pp. 1520-5.
Zhang B, Peng W, Li H, et al. Plasma vaspin concentrations are decreased in acute coronary syndrome, but unchanged in patients without coronary lesions. Clin Biochem. 2013;46(15):1520-5.
Zhang, B., Peng, W., Li, H., Lu, Y., Zhuang, J., Wang, K., Su, Y., & Xu, Y. (2013). Plasma vaspin concentrations are decreased in acute coronary syndrome, but unchanged in patients without coronary lesions. Clinical Biochemistry, 46(15), 1520-5. https://doi.org/10.1016/j.clinbiochem.2013.06.028
Zhang B, et al. Plasma Vaspin Concentrations Are Decreased in Acute Coronary Syndrome, but Unchanged in Patients Without Coronary Lesions. Clin Biochem. 2013;46(15):1520-5. PubMed PMID: 23850850.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma vaspin concentrations are decreased in acute coronary syndrome, but unchanged in patients without coronary lesions. AU - Zhang,Baowei, AU - Peng,Wenhui, AU - Li,Hailing, AU - Lu,Yuyan, AU - Zhuang,Jianhui, AU - Wang,Ke, AU - Su,Yang, AU - Xu,Yawei, Y1 - 2013/07/11/ PY - 2013/03/13/received PY - 2013/06/25/revised PY - 2013/06/26/accepted PY - 2013/7/16/entrez PY - 2013/7/16/pubmed PY - 2014/4/5/medline KW - 2-hour post-load plasma glucose KW - ALT KW - AMI KW - Acute coronary syndrome KW - Acute myocardial infarction KW - BMI KW - CAD KW - CAG KW - CRP KW - Coronary artery disease KW - FPG KW - HC KW - HDL-C KW - HbA1c KW - LDL-C KW - LVEF KW - OR KW - PG2h KW - ROC KW - SAP KW - SD KW - TC KW - TG KW - TnT KW - UAP KW - Vaspin KW - WBC KW - acute myocardial infarction KW - alanine aminotransferase KW - body mass index KW - c reactive protein KW - coronary angiography KW - coronary artery disease KW - fasting plasma glucose KW - glycosylated hemoglobin KW - healthy control KW - high-density lipoprotein cholesterol KW - left ventricular ejection fraction KW - low-density lipoprotein cholesterol KW - odd risk KW - receiver operating characteristic KW - stable angina pectoris KW - standard deviation KW - total cholesterol KW - triglyceride KW - troponin T KW - unstable angina pectoris KW - white blood cell count SP - 1520 EP - 5 JF - Clinical biochemistry JO - Clin Biochem VL - 46 IS - 15 N2 - OBJECTIVE: Previous studies suggested that decreased serum vaspin levels were associated with coronary artery disease (CAD). The present study aimed to investigate the association between plasma vaspin levels and different states of CAD. DESIGN AND METHODS: A total of 162 patients with coronary angiography (CAG) proved that CAD was enrolled. Additional 103 patients complained with "chest discomfort" with negative CAG, and 60 normal subjects were enrolled in this study. The levels of plasma vaspin, adiponectin, clinical parameters, lipid profile and C reactive protein (CRP) were measured. RESULTS: The levels of plasma vaspin were significantly lower in the CAD group (0.47±0.63 μg/L) than those in the healthy group and CAG (-) group (all p<0.001). In CAD group, the pos hoc analysis showed that serum vaspin concentration in acute myocardial infarction group (0.21±0.19 μg/L) was significantly lower than that in the unstable angina pectoris group (0.40±0.37 μg/L) (p=0.012), and serum vaspin concentration in unstable angina pectoris was significantly lower than that in stable angina pectoris group (0.92±0.94 μg/L) (p=0.013). The plasma vaspin concentration was also negatively correlated with the severity of CAD (1-vessel: 0.86±0.90 μg/L; 2-vessel: 0.36±0.39 μg/L; 3-vessel: 0.21±0.16 μg/L). The plasma vaspin concentration in CAG (-) group with "chest discomfort" (1.93±2.57 μg/L) was similar to the healthy control group (2.18±3.49μg/L). CONCLUSIONS: The plasma vaspin concentration correlated to the severity of CAD. Furthermore, plasma vaspin has a value of avoiding patients without CAD from unnecessary CAG. SN - 1873-2933 UR - https://www.unboundmedicine.com/medline/citation/23850850/Plasma_vaspin_concentrations_are_decreased_in_acute_coronary_syndrome_but_unchanged_in_patients_without_coronary_lesions_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-9120(13)00305-6 DB - PRIME DP - Unbound Medicine ER -