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Combined caffeine and bright light reduces dangerous driving in sleep-deprived healthy volunteers: a pilot cross-over randomised controlled trial.
Neurophysiol Clin. 2013 Jun; 43(3):161-9.NC

Abstract

AIM OF THE STUDY

To explore the effects of caffeine and bright light therapy on simulated nighttime driving in sleep-deprived healthy volunteers.

PARTICIPANTS AND METHODS

Twelve male healthy volunteers aged 20 to 50 years participated in a randomized cross-over study of simulated nighttime driving at a sleep laboratory, followed by recovery sleep with polysomnography at home. The volunteers received variable combinations of caffeine 200mg (C+), caffeine placebo (C-), bright light 10,000 lux (L+), and bright light placebo<50 lux (L-), in four sessions (C+L+, C+L-, C-L+, C-L-), in random order with a wash-out period of 7 days. Treatments were given at 1 a.m. and testing was performed at 1:30 a.m., 3 a.m., 4 a.m., and 6 a.m. Lane drifting was the primary outcome measure. Other measures were reaction times, self-rated fatigue, sleepiness and recovery sleep.

RESULTS

Without treatment, lane drifting increased throughout the night, and objective and subjective vigilance declined. Paired comparisons showed that lane drifting was significantly worse at 6 a.m. and at 4 a.m. than at 1:30 a.m. There was a global treatment effect on lane drifting. Lane drifting at 6 a.m. was significantly decreased with C+L+ compared to C-L-.

CONCLUSIONS

Bright light therapy combined with caffeine administered at 1 a.m. decreased lane drifting by healthy volunteers during simulated nighttime driving.

Authors+Show Affiliations

Unité du sommeil, service d'explorations fonctionnelles, hôpital Raymond-Poincaré, université de Versailles-St Quentin, AP-HP, 92380 Garches, France. sarah.hartley@rpc.aphp.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23856172

Citation

Hartley, S L., et al. "Combined Caffeine and Bright Light Reduces Dangerous Driving in Sleep-deprived Healthy Volunteers: a Pilot Cross-over Randomised Controlled Trial." Neurophysiologie Clinique = Clinical Neurophysiology, vol. 43, no. 3, 2013, pp. 161-9.
Hartley SL, Barbot F, Machou M, et al. Combined caffeine and bright light reduces dangerous driving in sleep-deprived healthy volunteers: a pilot cross-over randomised controlled trial. Neurophysiol Clin. 2013;43(3):161-9.
Hartley, S. L., Barbot, F., Machou, M., Lejaille, M., Moreau, B., Vaugier, I., Lofaso, F., & Quera-Salva, M. A. (2013). Combined caffeine and bright light reduces dangerous driving in sleep-deprived healthy volunteers: a pilot cross-over randomised controlled trial. Neurophysiologie Clinique = Clinical Neurophysiology, 43(3), 161-9. https://doi.org/10.1016/j.neucli.2013.04.001
Hartley SL, et al. Combined Caffeine and Bright Light Reduces Dangerous Driving in Sleep-deprived Healthy Volunteers: a Pilot Cross-over Randomised Controlled Trial. Neurophysiol Clin. 2013;43(3):161-9. PubMed PMID: 23856172.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined caffeine and bright light reduces dangerous driving in sleep-deprived healthy volunteers: a pilot cross-over randomised controlled trial. AU - Hartley,S L, AU - Barbot,F, AU - Machou,M, AU - Lejaille,M, AU - Moreau,B, AU - Vaugier,I, AU - Lofaso,F, AU - Quera-Salva,M A, Y1 - 2013/04/26/ PY - 2011/10/02/received PY - 2013/04/03/revised PY - 2013/04/04/accepted PY - 2013/7/17/entrez PY - 2013/7/17/pubmed PY - 2014/2/13/medline KW - Bright light KW - Caffeine KW - Caféine KW - Driving simulator KW - Lumière blanche KW - Privation de sommeil KW - Simulateur de conduite KW - Sleep deprivation KW - Vigilance SP - 161 EP - 9 JF - Neurophysiologie clinique = Clinical neurophysiology JO - Neurophysiol Clin VL - 43 IS - 3 N2 - AIM OF THE STUDY: To explore the effects of caffeine and bright light therapy on simulated nighttime driving in sleep-deprived healthy volunteers. PARTICIPANTS AND METHODS: Twelve male healthy volunteers aged 20 to 50 years participated in a randomized cross-over study of simulated nighttime driving at a sleep laboratory, followed by recovery sleep with polysomnography at home. The volunteers received variable combinations of caffeine 200mg (C+), caffeine placebo (C-), bright light 10,000 lux (L+), and bright light placebo<50 lux (L-), in four sessions (C+L+, C+L-, C-L+, C-L-), in random order with a wash-out period of 7 days. Treatments were given at 1 a.m. and testing was performed at 1:30 a.m., 3 a.m., 4 a.m., and 6 a.m. Lane drifting was the primary outcome measure. Other measures were reaction times, self-rated fatigue, sleepiness and recovery sleep. RESULTS: Without treatment, lane drifting increased throughout the night, and objective and subjective vigilance declined. Paired comparisons showed that lane drifting was significantly worse at 6 a.m. and at 4 a.m. than at 1:30 a.m. There was a global treatment effect on lane drifting. Lane drifting at 6 a.m. was significantly decreased with C+L+ compared to C-L-. CONCLUSIONS: Bright light therapy combined with caffeine administered at 1 a.m. decreased lane drifting by healthy volunteers during simulated nighttime driving. SN - 1769-7131 UR - https://www.unboundmedicine.com/medline/citation/23856172/Combined_caffeine_and_bright_light_reduces_dangerous_driving_in_sleep_deprived_healthy_volunteers:_a_pilot_cross_over_randomised_controlled_trial_ DB - PRIME DP - Unbound Medicine ER -