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Dietary intake of B vitamins and methionine and colorectal cancer risk.
Nutr Cancer. 2013; 65(5):659-67.NC

Abstract

B vitamins are involved in 1-carbon metabolism, which is necessary for DNA replication, DNA repair, and regulation of gene expression. Recent studies suggest inverse associations between folate and vitamin B6 intakes and colorectal cancer risk but associations with other B vitamins and methionine have not been widely studied. After following 14,645 men and 22,467 women for 15 yr on average, we ascertained 910 incident colorectal cancers. Dietary intakes were estimated using a 121-item food frequency questionnaire. Hazard ratios (HRs) and 95% confidence intervals were estimated using Cox regression. We found some evidence of a U-shaped relationship between colon cancer risk and vitamin B6 and an inverse U-shaped relationship between rectal cancer risk and B12 (test for the quadratic trend, P = 0.005 and P = 0.0005 respectively). For colon cancer, we observed a reduced risk associated with low methionine/high folate, HR = 0.63 (0.49, 0.80) and an increased risk associated with high methionine/high folate, HR = 1.36 (1.06, 1.74) (P interaction < 0.0001). Our study suggests a U-shaped association between colon cancer risk and vitamin B6 intake and an inverse U-shaped association between rectal cancer risk and vitamin B12. Adequate folate intake might protect against colon cancer risk in those with low methionine intake.

Authors+Show Affiliations

Cancer Epidemiology Centre, Cancer Council Victoria, Carlton, Victoria, Australia. julie.bassett@cancervic.org.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23859033

Citation

Bassett, Julie K., et al. "Dietary Intake of B Vitamins and Methionine and Colorectal Cancer Risk." Nutrition and Cancer, vol. 65, no. 5, 2013, pp. 659-67.
Bassett JK, Severi G, Hodge AM, et al. Dietary intake of B vitamins and methionine and colorectal cancer risk. Nutr Cancer. 2013;65(5):659-67.
Bassett, J. K., Severi, G., Hodge, A. M., Baglietto, L., Hopper, J. L., English, D. R., & Giles, G. G. (2013). Dietary intake of B vitamins and methionine and colorectal cancer risk. Nutrition and Cancer, 65(5), 659-67. https://doi.org/10.1080/01635581.2013.789114
Bassett JK, et al. Dietary Intake of B Vitamins and Methionine and Colorectal Cancer Risk. Nutr Cancer. 2013;65(5):659-67. PubMed PMID: 23859033.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary intake of B vitamins and methionine and colorectal cancer risk. AU - Bassett,Julie K, AU - Severi,Gianluca, AU - Hodge,Allison M, AU - Baglietto,Laura, AU - Hopper,John L, AU - English,Dallas R, AU - Giles,Graham G, PY - 2013/7/18/entrez PY - 2013/7/19/pubmed PY - 2014/2/12/medline SP - 659 EP - 67 JF - Nutrition and cancer JO - Nutr Cancer VL - 65 IS - 5 N2 - B vitamins are involved in 1-carbon metabolism, which is necessary for DNA replication, DNA repair, and regulation of gene expression. Recent studies suggest inverse associations between folate and vitamin B6 intakes and colorectal cancer risk but associations with other B vitamins and methionine have not been widely studied. After following 14,645 men and 22,467 women for 15 yr on average, we ascertained 910 incident colorectal cancers. Dietary intakes were estimated using a 121-item food frequency questionnaire. Hazard ratios (HRs) and 95% confidence intervals were estimated using Cox regression. We found some evidence of a U-shaped relationship between colon cancer risk and vitamin B6 and an inverse U-shaped relationship between rectal cancer risk and B12 (test for the quadratic trend, P = 0.005 and P = 0.0005 respectively). For colon cancer, we observed a reduced risk associated with low methionine/high folate, HR = 0.63 (0.49, 0.80) and an increased risk associated with high methionine/high folate, HR = 1.36 (1.06, 1.74) (P interaction < 0.0001). Our study suggests a U-shaped association between colon cancer risk and vitamin B6 intake and an inverse U-shaped association between rectal cancer risk and vitamin B12. Adequate folate intake might protect against colon cancer risk in those with low methionine intake. SN - 1532-7914 UR - https://www.unboundmedicine.com/medline/citation/23859033/Dietary_intake_of_B_vitamins_and_methionine_and_colorectal_cancer_risk_ L2 - https://www.tandfonline.com/doi/full/10.1080/01635581.2013.789114 DB - PRIME DP - Unbound Medicine ER -