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Development of controlled release osmotic pump tablet of glipizide solid dispersion.
Curr Drug Deliv. 2014; 11(6):817-27.CD

Abstract

PURPOSE

To develop controlled release osmotic pump tablets (COPT) of glipizide (GZ) solid dispersion (SD).

METHODS

In elementary osmotic pump (EOP) tablets, an osmotic core with the drug is surrounded by a semi-permeable membrane which is drilled with a delivery orifice. COPT tablets eliminate the need of drilling process as controlled release can be achieved by the presence of osmogen in the coating. Poorly water soluble drug molecule cannot give satisfactory drug release hence GZ solid dispersion was prepared in the present study. The SDs having different ratio of drug to Poloxamer (PXM) 188 were prepared by hot melt method and optimized by solubility study, drug content estimation and in vitro dissolution study. Effect of two independent variables, amount of osmogen (potassium chloride) and hydrophilic polymer (polyethylene oxide WSR 303), were investigated using 3(2) factorial design. Core and coated tablets were evaluated for pharmacotechnical parameters. In-vitro drug release profiles of COPT tablets were compared with marketed with push-pull osmotic pump tablet, Glucotrol XL.

RESULTS

Prepared core and coated tablets showed acceptable pharmacotechnical parameters. Drug release was directly proportional to initial level of hydrophilic polymer, but inversely related to the osmogen, confirming osmotic mechanism. Zero order drug release pattern was achieved which was comparable to marketed product.

CONCLUSION

Novel oral controlled release of glipizide was successfully achieved by incorporating glipizide solid dispersion into osmotic system.

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Authors+Show Affiliations

Patel GC
No affiliation info available
Asodaria KV
No affiliation info available
Patel HP
No affiliation info available
Shah DR
Maliba Pharmacy College, Bardoli Mahuva Road, Dist. Surat, Gujarat 394 350, India. gayatripatel26@gmail.com.

MeSH

Delayed-Action PreparationsDrug DesignGlipizideHumansHydrophobic and Hydrophilic InteractionsOsmotic PressurePoloxamerSolubilityTablets

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23859357

Citation

Patel, Gayatri C., et al. "Development of Controlled Release Osmotic Pump Tablet of Glipizide Solid Dispersion." Current Drug Delivery, vol. 11, no. 6, 2014, pp. 817-27.
Patel GC, Asodaria KV, Patel HP, et al. Development of controlled release osmotic pump tablet of glipizide solid dispersion. Curr Drug Deliv. 2014;11(6):817-27.
Patel, G. C., Asodaria, K. V., Patel, H. P., & Shah, D. R. (2014). Development of controlled release osmotic pump tablet of glipizide solid dispersion. Current Drug Delivery, 11(6), 817-27.
Patel GC, et al. Development of Controlled Release Osmotic Pump Tablet of Glipizide Solid Dispersion. Curr Drug Deliv. 2014;11(6):817-27. PubMed PMID: 23859357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development of controlled release osmotic pump tablet of glipizide solid dispersion. AU - Patel,Gayatri C, AU - Asodaria,Khushman V, AU - Patel,Hetal P, AU - Shah,Dinesh R, PY - 2014/03/21/received PY - 2014/04/19/revised PY - 2014/06/19/accepted PY - 2013/7/18/entrez PY - 2013/7/19/pubmed PY - 2015/9/24/medline SP - 817 EP - 27 JF - Current drug delivery JO - Curr Drug Deliv VL - 11 IS - 6 N2 - PURPOSE: To develop controlled release osmotic pump tablets (COPT) of glipizide (GZ) solid dispersion (SD). METHODS: In elementary osmotic pump (EOP) tablets, an osmotic core with the drug is surrounded by a semi-permeable membrane which is drilled with a delivery orifice. COPT tablets eliminate the need of drilling process as controlled release can be achieved by the presence of osmogen in the coating. Poorly water soluble drug molecule cannot give satisfactory drug release hence GZ solid dispersion was prepared in the present study. The SDs having different ratio of drug to Poloxamer (PXM) 188 were prepared by hot melt method and optimized by solubility study, drug content estimation and in vitro dissolution study. Effect of two independent variables, amount of osmogen (potassium chloride) and hydrophilic polymer (polyethylene oxide WSR 303), were investigated using 3(2) factorial design. Core and coated tablets were evaluated for pharmacotechnical parameters. In-vitro drug release profiles of COPT tablets were compared with marketed with push-pull osmotic pump tablet, Glucotrol XL. RESULTS: Prepared core and coated tablets showed acceptable pharmacotechnical parameters. Drug release was directly proportional to initial level of hydrophilic polymer, but inversely related to the osmogen, confirming osmotic mechanism. Zero order drug release pattern was achieved which was comparable to marketed product. CONCLUSION: Novel oral controlled release of glipizide was successfully achieved by incorporating glipizide solid dispersion into osmotic system. SN - 1875-5704 UR - https://www.unboundmedicine.com/medline/citation/23859357/Development_of_controlled_release_osmotic_pump_tablet_of_glipizide_solid_dispersion_ L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=1567-2018&volume=11&issue=6&spage=817&aulast=Patel DB - PRIME DP - Unbound Medicine ER -