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The incidence of acute pancreatitis: impact of social deprivation, alcohol consumption, seasonal and demographic factors.
Aliment Pharmacol Ther. 2013 Sep; 38(5):539-48.AP

Abstract

BACKGROUND

The incidence of acute pancreatitis has increased sharply in many European countries and the USA in recent years.

AIM

To establish trends in incidence and mortality for acute pancreatitis in Wales, UK, and to assess how incidence may be linked to factors including social deprivation, seasonal effects and alcohol consumption.

METHODS

Use of record linked inpatient, mortality and primary care data for 10,589 hospitalised cases of acute pancreatitis between 1999 and 2010.

RESULTS

The incidence of acute pancreatitis was 30.0 per 100,000 population overall, mortality was 6.4% at 60 days. Incidence increased significantly from 27.6 per 100,000 in 1999 to 36.4 in 2010 (average annual increase = 2.7% per year), there was little trend in mortality (0.2% average annual reduction). The largest increases in incidence were among women aged <35 years (7.9% per year) and men aged 35-44 (5.7%) and 45-54 (5.3%). Incidence was 1.9 times higher among the most deprived quintile of patients compared with the most affluent (3.9 times higher for alcoholic acute pancreatitis and 1.5 for gallstone acute pancreatitis). Acute pancreatitis was increased significantly during the Christmas and New Year weeks by 48% (95% CI = 24-77%) for alcoholic aetiology, but not for gallstone aetiology (9%). Alcoholic admissions were increased with higher consumption of spirits and beer, but not wine.

CONCLUSIONS

The study shows an elevated rate of alcoholic acute pancreatitis during the Christmas and New Year period. Acute pancreatitis continues to rise, most rapidly for young women, while alcoholic acute pancreatitis is linked strongly with social deprivation.

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Authors+Show Affiliations

Roberts SE
College of Medicine, Swansea University, Swansea, UK. stephen.e.roberts@swansea.ac.uk
Akbari A
No affiliation info available
Thorne K
No affiliation info available
Atkinson M
No affiliation info available
Evans PA
No affiliation info available

MeSH

Acute DiseaseAdolescentAdultAgedAged, 80 and overAlcohol DrinkingDemographyFemaleHumansIncidenceMaleMiddle AgedPancreatitis, AlcoholicPsychosocial DeprivationRisk FactorsSeasonsSocioeconomic FactorsWalesYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23859492

Citation

Roberts, S E., et al. "The Incidence of Acute Pancreatitis: Impact of Social Deprivation, Alcohol Consumption, Seasonal and Demographic Factors." Alimentary Pharmacology & Therapeutics, vol. 38, no. 5, 2013, pp. 539-48.
Roberts SE, Akbari A, Thorne K, et al. The incidence of acute pancreatitis: impact of social deprivation, alcohol consumption, seasonal and demographic factors. Aliment Pharmacol Ther. 2013;38(5):539-48.
Roberts, S. E., Akbari, A., Thorne, K., Atkinson, M., & Evans, P. A. (2013). The incidence of acute pancreatitis: impact of social deprivation, alcohol consumption, seasonal and demographic factors. Alimentary Pharmacology & Therapeutics, 38(5), 539-48. https://doi.org/10.1111/apt.12408
Roberts SE, et al. The Incidence of Acute Pancreatitis: Impact of Social Deprivation, Alcohol Consumption, Seasonal and Demographic Factors. Aliment Pharmacol Ther. 2013;38(5):539-48. PubMed PMID: 23859492.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The incidence of acute pancreatitis: impact of social deprivation, alcohol consumption, seasonal and demographic factors. AU - Roberts,S E, AU - Akbari,A, AU - Thorne,K, AU - Atkinson,M, AU - Evans,P A, Y1 - 2013/07/16/ PY - 2013/03/27/received PY - 2013/04/29/revised PY - 2013/06/21/revised PY - 2013/06/21/accepted PY - 2013/7/18/entrez PY - 2013/7/19/pubmed PY - 2014/2/22/medline SP - 539 EP - 48 JF - Alimentary pharmacology & therapeutics JO - Aliment Pharmacol Ther VL - 38 IS - 5 N2 - BACKGROUND: The incidence of acute pancreatitis has increased sharply in many European countries and the USA in recent years. AIM: To establish trends in incidence and mortality for acute pancreatitis in Wales, UK, and to assess how incidence may be linked to factors including social deprivation, seasonal effects and alcohol consumption. METHODS: Use of record linked inpatient, mortality and primary care data for 10,589 hospitalised cases of acute pancreatitis between 1999 and 2010. RESULTS: The incidence of acute pancreatitis was 30.0 per 100,000 population overall, mortality was 6.4% at 60 days. Incidence increased significantly from 27.6 per 100,000 in 1999 to 36.4 in 2010 (average annual increase = 2.7% per year), there was little trend in mortality (0.2% average annual reduction). The largest increases in incidence were among women aged <35 years (7.9% per year) and men aged 35-44 (5.7%) and 45-54 (5.3%). Incidence was 1.9 times higher among the most deprived quintile of patients compared with the most affluent (3.9 times higher for alcoholic acute pancreatitis and 1.5 for gallstone acute pancreatitis). Acute pancreatitis was increased significantly during the Christmas and New Year weeks by 48% (95% CI = 24-77%) for alcoholic aetiology, but not for gallstone aetiology (9%). Alcoholic admissions were increased with higher consumption of spirits and beer, but not wine. CONCLUSIONS: The study shows an elevated rate of alcoholic acute pancreatitis during the Christmas and New Year period. Acute pancreatitis continues to rise, most rapidly for young women, while alcoholic acute pancreatitis is linked strongly with social deprivation. SN - 1365-2036 UR - https://www.unboundmedicine.com/medline/citation/23859492/The_incidence_of_acute_pancreatitis:_impact_of_social_deprivation_alcohol_consumption_seasonal_and_demographic_factors_ L2 - https://doi.org/10.1111/apt.12408 DB - PRIME DP - Unbound Medicine ER -