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Effects of harmful dinoflagellate Ostreopsis cf. ovata exposure on immunological, histological and oxidative responses of mussels Mytilus galloprovincialis.
Fish Shellfish Immunol. 2013 Sep; 35(3):941-50.FS

Abstract

In the last decade massive blooms of the Ostreopsis cf. ovata have occurred in the Mediterranean basin, posing great concern to both environmental and human health. Biotoxicological and chemical studies demonstrated that O. cf. ovata produces palytoxin and ovatoxins; besides direct respiratory effects on humans due to inhalation of marine toxic aerosols, O. cf. ovata blooms can cause adverse effects on benthic invertebrates. The main aim of this study was to highlight the role of immunological, cellular and oxidative mechanisms in modulating the toxicity induced by O. cf. ovata in mussels Mytilus galloprovincialis. Organisms were exposed in laboratory condition to O. cf. ovata and analysed after 7 and 14 days of exposure. Obtained results demonstrated a clear involvement of the immune system with a significant decrement of granulocytes respect to the hyalinocytes type cells, a diminished phagocytosis activity and a reduced lysosomal membrane stability in haemocytes, after both 7 and 14 days of exposure. Histological analyses showed a decrease of the digestive gland wall thickness, dilatation of the tubules, haemocytes infiltration into the digestive gland and a decrement of neutral lipid levels in exposed mussels; similar results suggest a possible inhibition of the feeding activity, with a consequent induction of authophagic phenomena and utilization of stored reserve products such as neutral lipids. Antioxidant parameters revealed a limited role of O. cf. ovata to induce oxidative stress in mussels exposed under laboratory conditions excepting for a certain increase of catalase, glutathione reductase and glutathione peroxidases activities, and a significantly higher capability to neutralize peroxyl radicals in mussels exposed for 14 days. Although the obtained results suggest a non-specific response of mussels to the O. cf. ovata exposure, observed effects on the general health status of exposed mussels should be adequately considered when assessing the ecological relevance of these algal blooms.

Authors+Show Affiliations

Dipartimento di Scienze della Vita e dell'Ambiente, Università Politecnica delle Marche, Via Brecce Bianche, 60131 Ancona, Italy. s.gorbi@univpm.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23859877

Citation

Gorbi, S, et al. "Effects of Harmful Dinoflagellate Ostreopsis Cf. Ovata Exposure On Immunological, Histological and Oxidative Responses of Mussels Mytilus Galloprovincialis." Fish & Shellfish Immunology, vol. 35, no. 3, 2013, pp. 941-50.
Gorbi S, Avio GC, Benedetti M, et al. Effects of harmful dinoflagellate Ostreopsis cf. ovata exposure on immunological, histological and oxidative responses of mussels Mytilus galloprovincialis. Fish Shellfish Immunol. 2013;35(3):941-50.
Gorbi, S., Avio, G. C., Benedetti, M., Totti, C., Accoroni, S., Pichierri, S., Bacchiocchi, S., Orletti, R., Graziosi, T., & Regoli, F. (2013). Effects of harmful dinoflagellate Ostreopsis cf. ovata exposure on immunological, histological and oxidative responses of mussels Mytilus galloprovincialis. Fish & Shellfish Immunology, 35(3), 941-50. https://doi.org/10.1016/j.fsi.2013.07.003
Gorbi S, et al. Effects of Harmful Dinoflagellate Ostreopsis Cf. Ovata Exposure On Immunological, Histological and Oxidative Responses of Mussels Mytilus Galloprovincialis. Fish Shellfish Immunol. 2013;35(3):941-50. PubMed PMID: 23859877.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of harmful dinoflagellate Ostreopsis cf. ovata exposure on immunological, histological and oxidative responses of mussels Mytilus galloprovincialis. AU - Gorbi,S, AU - Avio,G C, AU - Benedetti,M, AU - Totti,C, AU - Accoroni,S, AU - Pichierri,S, AU - Bacchiocchi,S, AU - Orletti,R, AU - Graziosi,T, AU - Regoli,F, Y1 - 2013/07/13/ PY - 2013/03/28/received PY - 2013/06/10/revised PY - 2013/07/05/accepted PY - 2013/7/18/entrez PY - 2013/7/19/pubmed PY - 2014/4/29/medline KW - Antioxidant response KW - Haemocytes KW - Immune response KW - Mytilus galloprovincialis KW - Ostreopsis cf. ovata SP - 941 EP - 50 JF - Fish & shellfish immunology JO - Fish Shellfish Immunol VL - 35 IS - 3 N2 - In the last decade massive blooms of the Ostreopsis cf. ovata have occurred in the Mediterranean basin, posing great concern to both environmental and human health. Biotoxicological and chemical studies demonstrated that O. cf. ovata produces palytoxin and ovatoxins; besides direct respiratory effects on humans due to inhalation of marine toxic aerosols, O. cf. ovata blooms can cause adverse effects on benthic invertebrates. The main aim of this study was to highlight the role of immunological, cellular and oxidative mechanisms in modulating the toxicity induced by O. cf. ovata in mussels Mytilus galloprovincialis. Organisms were exposed in laboratory condition to O. cf. ovata and analysed after 7 and 14 days of exposure. Obtained results demonstrated a clear involvement of the immune system with a significant decrement of granulocytes respect to the hyalinocytes type cells, a diminished phagocytosis activity and a reduced lysosomal membrane stability in haemocytes, after both 7 and 14 days of exposure. Histological analyses showed a decrease of the digestive gland wall thickness, dilatation of the tubules, haemocytes infiltration into the digestive gland and a decrement of neutral lipid levels in exposed mussels; similar results suggest a possible inhibition of the feeding activity, with a consequent induction of authophagic phenomena and utilization of stored reserve products such as neutral lipids. Antioxidant parameters revealed a limited role of O. cf. ovata to induce oxidative stress in mussels exposed under laboratory conditions excepting for a certain increase of catalase, glutathione reductase and glutathione peroxidases activities, and a significantly higher capability to neutralize peroxyl radicals in mussels exposed for 14 days. Although the obtained results suggest a non-specific response of mussels to the O. cf. ovata exposure, observed effects on the general health status of exposed mussels should be adequately considered when assessing the ecological relevance of these algal blooms. SN - 1095-9947 UR - https://www.unboundmedicine.com/medline/citation/23859877/Effects_of_harmful_dinoflagellate_Ostreopsis_cf__ovata_exposure_on_immunological_histological_and_oxidative_responses_of_mussels_Mytilus_galloprovincialis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1050-4648(13)00641-4 DB - PRIME DP - Unbound Medicine ER -