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Anthropometric measures and epithelial ovarian cancer risk among Chinese women: results from the Shanghai Women's Health Study.
Br J Cancer 2013; 109(3):751-5BJ

Abstract

BACKGROUND

Studies of anthropometric measures and ovarian cancer risk have predominantly included women of European descent with mixed findings.

METHODS

Data from the prospective Shanghai Women's Health Study (SWHS) were used to evaluate associations between anthropometric measures and risk of epithelial ovarian cancer (EOC). Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated by Cox proportional hazards regression.

RESULTS

A total of 152 EOC cases occurred among 70 258 women. Increasing quartiles of weight, hip circumference, and weight gain during adulthood were associated with significantly increased EOC risks. Body mass index (BMI) was also associated; overweight (25BMI<29.99) and obese women (BMI30.0) had significantly increased risks (HR: 1.49, 95% CI: 1.05, 2.13, and HR: 2.42, 95% CI: 1.37, 4.28, respectively). No significant associations were observed for height, waist circumference, waist-to-hip ratio (WHR), and waist-to-height ratio (WHER).

CONCLUSION

Results from this large prospective study of Chinese women support the hypothesis that general adiposity contributes to the aetiology of ovarian cancer.

Authors+Show Affiliations

Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23860524

Citation

Ma, X, et al. "Anthropometric Measures and Epithelial Ovarian Cancer Risk Among Chinese Women: Results From the Shanghai Women's Health Study." British Journal of Cancer, vol. 109, no. 3, 2013, pp. 751-5.
Ma X, Beeghly-Fadiel A, Shu XO, et al. Anthropometric measures and epithelial ovarian cancer risk among Chinese women: results from the Shanghai Women's Health Study. Br J Cancer. 2013;109(3):751-5.
Ma, X., Beeghly-Fadiel, A., Shu, X. O., Li, H., Yang, G., Gao, Y. T., & Zheng, W. (2013). Anthropometric measures and epithelial ovarian cancer risk among Chinese women: results from the Shanghai Women's Health Study. British Journal of Cancer, 109(3), pp. 751-5. doi:10.1038/bjc.2013.384.
Ma X, et al. Anthropometric Measures and Epithelial Ovarian Cancer Risk Among Chinese Women: Results From the Shanghai Women's Health Study. Br J Cancer. 2013 Aug 6;109(3):751-5. PubMed PMID: 23860524.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anthropometric measures and epithelial ovarian cancer risk among Chinese women: results from the Shanghai Women's Health Study. AU - Ma,X, AU - Beeghly-Fadiel,A, AU - Shu,X-O, AU - Li,H, AU - Yang,G, AU - Gao,Y-T, AU - Zheng,W, Y1 - 2013/07/16/ PY - 2013/03/11/received PY - 2013/06/19/revised PY - 2013/06/21/accepted PY - 2013/7/18/entrez PY - 2013/7/19/pubmed PY - 2013/12/16/medline SP - 751 EP - 5 JF - British journal of cancer JO - Br. J. Cancer VL - 109 IS - 3 N2 - BACKGROUND: Studies of anthropometric measures and ovarian cancer risk have predominantly included women of European descent with mixed findings. METHODS: Data from the prospective Shanghai Women's Health Study (SWHS) were used to evaluate associations between anthropometric measures and risk of epithelial ovarian cancer (EOC). Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated by Cox proportional hazards regression. RESULTS: A total of 152 EOC cases occurred among 70 258 women. Increasing quartiles of weight, hip circumference, and weight gain during adulthood were associated with significantly increased EOC risks. Body mass index (BMI) was also associated; overweight (25BMI<29.99) and obese women (BMI30.0) had significantly increased risks (HR: 1.49, 95% CI: 1.05, 2.13, and HR: 2.42, 95% CI: 1.37, 4.28, respectively). No significant associations were observed for height, waist circumference, waist-to-hip ratio (WHR), and waist-to-height ratio (WHER). CONCLUSION: Results from this large prospective study of Chinese women support the hypothesis that general adiposity contributes to the aetiology of ovarian cancer. SN - 1532-1827 UR - https://www.unboundmedicine.com/medline/citation/23860524/Anthropometric_measures_and_epithelial_ovarian_cancer_risk_among_Chinese_women:_results_from_the_Shanghai_Women's_Health_Study_ L2 - http://dx.doi.org/10.1038/bjc.2013.384 DB - PRIME DP - Unbound Medicine ER -