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Differences in aqueous concentrations of cytokines in macular edema secondary to branch and central retinal vein occlusion.
PLoS One. 2013; 8(7):e68149.Plos

Abstract

PURPOSE

This study investigates the differential aqueous concentrations of interleukin 6, 8, 1β (IL-6, IL-8, IL-1β, respectively), serum amyloid A (SAA), transforming growth factor (TGF)-β, basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF) in eyes with macular edema as a result of a branch retinal vein occlusion (BRVO) or central retinal vein occlusion (CRVO).

PRINCIPAL FINDINGS

Significantly higher concentrations of IL-6, IL-8, IL-1β, TGF-β, bFGF, SAA, and VEGF were found in the aqueous humor of CRVO and BRVO patients than in the aqueous humor of control patients. A significant correlation was observed between the concentration of bFGF and the inner central macular thickness (CMT) of BRVO patients (r = 0.688; P = 0.02). A significant correlation was observed between the concentration of SAA and both the full and outer CMT of the ischemic group (r = 0.545 and 0.683, respectively; P = 0.04 and 0.01, respectively). In the non-ischemic group, the level of IL-6 was significantly associated with inner CMT (r = 0.560; P = 0.03). The full and outer CMT was significantly reduced in CRVO patients when compared with BRVO patients (P = 0.02 and 0.02, respectively) after injection of intravitreal bevacizumab (IVB) at 4 weeks.

SIGNIFICANCE

Serum amyloid A as a major protein involved in the acute and chronic stages of inflammation, and IL-6 and bFGF were significantly associated with the extent of macular edema in patients with RVO. Besides VEGF, other inflammatory cytokines and angiogenesic factors may be associated with RVO. This finding may have implications for the medical treatment of RVO.

Authors+Show Affiliations

Department of Ophthalmology, People's Hospital, Peking University, and Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23861862

Citation

Feng, Jing, et al. "Differences in Aqueous Concentrations of Cytokines in Macular Edema Secondary to Branch and Central Retinal Vein Occlusion." PloS One, vol. 8, no. 7, 2013, pp. e68149.
Feng J, Zhao T, Zhang Y, et al. Differences in aqueous concentrations of cytokines in macular edema secondary to branch and central retinal vein occlusion. PLoS One. 2013;8(7):e68149.
Feng, J., Zhao, T., Zhang, Y., Ma, Y., & Jiang, Y. (2013). Differences in aqueous concentrations of cytokines in macular edema secondary to branch and central retinal vein occlusion. PloS One, 8(7), e68149. https://doi.org/10.1371/journal.pone.0068149
Feng J, et al. Differences in Aqueous Concentrations of Cytokines in Macular Edema Secondary to Branch and Central Retinal Vein Occlusion. PLoS One. 2013;8(7):e68149. PubMed PMID: 23861862.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differences in aqueous concentrations of cytokines in macular edema secondary to branch and central retinal vein occlusion. AU - Feng,Jing, AU - Zhao,Tong, AU - Zhang,Yan, AU - Ma,Yan, AU - Jiang,Yanrong, Y1 - 2013/07/05/ PY - 2013/03/18/received PY - 2013/05/26/accepted PY - 2013/7/18/entrez PY - 2013/7/19/pubmed PY - 2014/2/14/medline SP - e68149 EP - e68149 JF - PloS one JO - PLoS One VL - 8 IS - 7 N2 - PURPOSE: This study investigates the differential aqueous concentrations of interleukin 6, 8, 1β (IL-6, IL-8, IL-1β, respectively), serum amyloid A (SAA), transforming growth factor (TGF)-β, basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF) in eyes with macular edema as a result of a branch retinal vein occlusion (BRVO) or central retinal vein occlusion (CRVO). PRINCIPAL FINDINGS: Significantly higher concentrations of IL-6, IL-8, IL-1β, TGF-β, bFGF, SAA, and VEGF were found in the aqueous humor of CRVO and BRVO patients than in the aqueous humor of control patients. A significant correlation was observed between the concentration of bFGF and the inner central macular thickness (CMT) of BRVO patients (r = 0.688; P = 0.02). A significant correlation was observed between the concentration of SAA and both the full and outer CMT of the ischemic group (r = 0.545 and 0.683, respectively; P = 0.04 and 0.01, respectively). In the non-ischemic group, the level of IL-6 was significantly associated with inner CMT (r = 0.560; P = 0.03). The full and outer CMT was significantly reduced in CRVO patients when compared with BRVO patients (P = 0.02 and 0.02, respectively) after injection of intravitreal bevacizumab (IVB) at 4 weeks. SIGNIFICANCE: Serum amyloid A as a major protein involved in the acute and chronic stages of inflammation, and IL-6 and bFGF were significantly associated with the extent of macular edema in patients with RVO. Besides VEGF, other inflammatory cytokines and angiogenesic factors may be associated with RVO. This finding may have implications for the medical treatment of RVO. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/23861862/Differences_in_aqueous_concentrations_of_cytokines_in_macular_edema_secondary_to_branch_and_central_retinal_vein_occlusion_ L2 - https://dx.plos.org/10.1371/journal.pone.0068149 DB - PRIME DP - Unbound Medicine ER -