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Helicobacter pylori infection as a cause of iron deficiency anaemia of unknown origin.
World J Gastroenterol. 2013 Jul 14; 19(26):4166-71.WJ

Abstract

AIM

To assess the aetiological role of Helicobacter pylori (H. pylori) infection in adult patients with iron-refractory or iron-dependent anaemia of previously unknown origin.

METHODS

Consecutive patients with chronic iron-deficient anaemia (IDA) with H. pylori infection and a negative standard work-up were prospectively evaluated. All of them had either iron refractoriness or iron dependency. Response to H. pylori eradication was assessed at 6 and 12 mo from follow-up. H. pylori infection was considered to be the cause of the anaemia when a complete anaemia resolution without iron supplements was observed after eradication.

RESULTS

H. pylori was eradicated in 88 of the 89 patients. In the non-eradicated patient the four eradicating regimens failed. There were violations of protocol in 4 patients, for whom it was not possible to ascertain the cause of the anaemia. Thus, 84 H. pylori eradicated patients (10 men; 74 women) were available to assess the effect of eradication on IDA. H. pylori infection was considered to be the aetiology of IDA in 32 patients (38.1%; 95%CI: 28.4%-48.8%). This was more frequent in men/postmenopausal women than in premenopausal women (75% vs 23.3%; P < 0.0001) with an OR of 9.8 (95%CI: 3.3-29.6). In these patients, anaemia resolution occurred in the first follow-up visit at 6 mo, and no anaemia or iron deficiency relapse was observed after a mean follow-up of 21 ± 2 mo.

CONCLUSION

Gastric H. pylori infection is a frequent cause of iron-refractory or iron-dependent anaemia of previously unknown origin in adult patients.

Authors+Show Affiliations

Department of Gastroenterology, Hospital Universitari Mútua Terrassa, 08221 Terrassa, Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23864779

Citation

Monzón, Helena, et al. "Helicobacter Pylori Infection as a Cause of Iron Deficiency Anaemia of Unknown Origin." World Journal of Gastroenterology, vol. 19, no. 26, 2013, pp. 4166-71.
Monzón H, Forné M, Esteve M, et al. Helicobacter pylori infection as a cause of iron deficiency anaemia of unknown origin. World J Gastroenterol. 2013;19(26):4166-71.
Monzón, H., Forné, M., Esteve, M., Rosinach, M., Loras, C., Espinós, J. C., Viver, J. M., Salas, A., & Fernández-Bañares, F. (2013). Helicobacter pylori infection as a cause of iron deficiency anaemia of unknown origin. World Journal of Gastroenterology, 19(26), 4166-71. https://doi.org/10.3748/wjg.v19.i26.4166
Monzón H, et al. Helicobacter Pylori Infection as a Cause of Iron Deficiency Anaemia of Unknown Origin. World J Gastroenterol. 2013 Jul 14;19(26):4166-71. PubMed PMID: 23864779.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Helicobacter pylori infection as a cause of iron deficiency anaemia of unknown origin. AU - Monzón,Helena, AU - Forné,Montserrat, AU - Esteve,Maria, AU - Rosinach,Mercé, AU - Loras,Carme, AU - Espinós,Jorge C, AU - Viver,Josep M, AU - Salas,Antonio, AU - Fernández-Bañares,Fernando, PY - 2013/02/05/received PY - 2013/04/16/revised PY - 2013/06/01/accepted PY - 2013/7/19/entrez PY - 2013/7/19/pubmed PY - 2014/1/3/medline KW - Gluten-sensitive enteropathy KW - Helicobacter pylori KW - Iron refractoriness KW - Iron-deficiency anaemia KW - Menopause SP - 4166 EP - 71 JF - World journal of gastroenterology JO - World J Gastroenterol VL - 19 IS - 26 N2 - AIM: To assess the aetiological role of Helicobacter pylori (H. pylori) infection in adult patients with iron-refractory or iron-dependent anaemia of previously unknown origin. METHODS: Consecutive patients with chronic iron-deficient anaemia (IDA) with H. pylori infection and a negative standard work-up were prospectively evaluated. All of them had either iron refractoriness or iron dependency. Response to H. pylori eradication was assessed at 6 and 12 mo from follow-up. H. pylori infection was considered to be the cause of the anaemia when a complete anaemia resolution without iron supplements was observed after eradication. RESULTS: H. pylori was eradicated in 88 of the 89 patients. In the non-eradicated patient the four eradicating regimens failed. There were violations of protocol in 4 patients, for whom it was not possible to ascertain the cause of the anaemia. Thus, 84 H. pylori eradicated patients (10 men; 74 women) were available to assess the effect of eradication on IDA. H. pylori infection was considered to be the aetiology of IDA in 32 patients (38.1%; 95%CI: 28.4%-48.8%). This was more frequent in men/postmenopausal women than in premenopausal women (75% vs 23.3%; P < 0.0001) with an OR of 9.8 (95%CI: 3.3-29.6). In these patients, anaemia resolution occurred in the first follow-up visit at 6 mo, and no anaemia or iron deficiency relapse was observed after a mean follow-up of 21 ± 2 mo. CONCLUSION: Gastric H. pylori infection is a frequent cause of iron-refractory or iron-dependent anaemia of previously unknown origin in adult patients. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/23864779/Helicobacter_pylori_infection_as_a_cause_of_iron_deficiency_anaemia_of_unknown_origin_ L2 - https://www.wjgnet.com/1007-9327/full/v19/i26/4166.htm DB - PRIME DP - Unbound Medicine ER -