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Frequency of nut consumption and mortality risk in the PREDIMED nutrition intervention trial.
BMC Med. 2013 Jul 16; 11:164.BM

Abstract

BACKGROUND

Prospective studies in non-Mediterranean populations have consistently related increasing nut consumption to lower coronary heart disease mortality. A small protective effect on all-cause and cancer mortality has also been suggested. To examine the association between frequency of nut consumption and mortality in individuals at high cardiovascular risk from Spain, a Mediterranean country with a relatively high average nut intake per person.

METHODS

We evaluated 7,216 men and women aged 55 to 80 years randomized to 1 of 3 interventions (Mediterranean diets supplemented with nuts or olive oil and control diet) in the PREDIMED ('PREvención con DIeta MEDiterránea') study. Nut consumption was assessed at baseline and mortality was ascertained by medical records and linkage to the National Death Index. Multivariable-adjusted Cox regression and multivariable analyses with generalized estimating equation models were used to assess the association between yearly repeated measurements of nut consumption and mortality.

RESULTS

During a median follow-up of 4.8 years, 323 total deaths, 81 cardiovascular deaths and 130 cancer deaths occurred. Nut consumption was associated with a significantly reduced risk of all-cause mortality (P for trend<0.05, all). Compared to non-consumers, subjects consuming nuts>3 servings/week (32% of the cohort) had a 39% lower mortality risk (hazard ratio (HR) 0.61; 95% CI 0.45 to 0.83). A similar protective effect against cardiovascular and cancer mortality was observed. Participants allocated to the Mediterranean diet with nuts group who consumed nuts>3 servings/week at baseline had the lowest total mortality risk (HR 0.37; 95% CI 0.22 to 0.66).

CONCLUSIONS

Increased frequency of nut consumption was associated with a significantly reduced risk of mortality in a Mediterranean population at high cardiovascular risk.Please see related commentary: http://www.biomedcentral.com/1741-7015/11/165.

TRIAL REGISTRATION

Clinicaltrials.gov. International Standard Randomized Controlled Trial Number (ISRCTN): 35739639. Registration date: 5 October 2005.

Links

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Authors+Show Affiliations

Guasch-Ferré M
Human Nutrition Unit, Hospital Universitari de Sant Joan de Reus, Faculty of Medicine and Health Sciences, IISPV (Institut d'Investigació Sanitària Pere Virgili), Universitat Rovira i Virgili, Reus, Spain.
Bulló M
No affiliation info available
Martínez-González MÁ
No affiliation info available
Ros E
No affiliation info available
Corella D
No affiliation info available
Estruch R
No affiliation info available
Fitó M
No affiliation info available
Arós F
No affiliation info available
Wärnberg J
No affiliation info available
Fiol M
No affiliation info available
Lapetra J
No affiliation info available
Vinyoles E
No affiliation info available
Lamuela-Raventós RM
No affiliation info available
Serra-Majem L
No affiliation info available
Pintó X
No affiliation info available
Ruiz-Gutiérrez V
No affiliation info available
Basora J
No affiliation info available
Salas-Salvadó J
No affiliation info available
PREDIMED study group
No affiliation info available

MeSH

AgedAged, 80 and overCohort StudiesCoronary DiseaseDiet, MediterraneanFeeding BehaviorFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleMiddle AgedNutsOlive OilPlant OilsRisk FactorsSpain

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23866098

Citation

Guasch-Ferré, Marta, et al. "Frequency of Nut Consumption and Mortality Risk in the PREDIMED Nutrition Intervention Trial." BMC Medicine, vol. 11, 2013, p. 164.
Guasch-Ferré M, Bulló M, Martínez-González MÁ, et al. Frequency of nut consumption and mortality risk in the PREDIMED nutrition intervention trial. BMC Med. 2013;11:164.
Guasch-Ferré, M., Bulló, M., Martínez-González, M. Á., Ros, E., Corella, D., Estruch, R., Fitó, M., Arós, F., Wärnberg, J., Fiol, M., Lapetra, J., Vinyoles, E., Lamuela-Raventós, R. M., Serra-Majem, L., Pintó, X., Ruiz-Gutiérrez, V., Basora, J., & Salas-Salvadó, J. (2013). Frequency of nut consumption and mortality risk in the PREDIMED nutrition intervention trial. BMC Medicine, 11, 164. https://doi.org/10.1186/1741-7015-11-164
Guasch-Ferré M, et al. Frequency of Nut Consumption and Mortality Risk in the PREDIMED Nutrition Intervention Trial. BMC Med. 2013 Jul 16;11:164. PubMed PMID: 23866098.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Frequency of nut consumption and mortality risk in the PREDIMED nutrition intervention trial. AU - Guasch-Ferré,Marta, AU - Bulló,Mònica, AU - Martínez-González,Miguel Ángel, AU - Ros,Emilio, AU - Corella,Dolores, AU - Estruch,Ramon, AU - Fitó,Montserrat, AU - Arós,Fernando, AU - Wärnberg,Julia, AU - Fiol,Miquel, AU - Lapetra,José, AU - Vinyoles,Ernest, AU - Lamuela-Raventós,Rosa Maria, AU - Serra-Majem,Lluís, AU - Pintó,Xavier, AU - Ruiz-Gutiérrez,Valentina, AU - Basora,Josep, AU - Salas-Salvadó,Jordi, AU - ,, Y1 - 2013/07/16/ PY - 2013/04/22/received PY - 2013/05/22/accepted PY - 2013/7/20/entrez PY - 2013/7/20/pubmed PY - 2014/2/5/medline SP - 164 EP - 164 JF - BMC medicine JO - BMC Med VL - 11 N2 - BACKGROUND: Prospective studies in non-Mediterranean populations have consistently related increasing nut consumption to lower coronary heart disease mortality. A small protective effect on all-cause and cancer mortality has also been suggested. To examine the association between frequency of nut consumption and mortality in individuals at high cardiovascular risk from Spain, a Mediterranean country with a relatively high average nut intake per person. METHODS: We evaluated 7,216 men and women aged 55 to 80 years randomized to 1 of 3 interventions (Mediterranean diets supplemented with nuts or olive oil and control diet) in the PREDIMED ('PREvención con DIeta MEDiterránea') study. Nut consumption was assessed at baseline and mortality was ascertained by medical records and linkage to the National Death Index. Multivariable-adjusted Cox regression and multivariable analyses with generalized estimating equation models were used to assess the association between yearly repeated measurements of nut consumption and mortality. RESULTS: During a median follow-up of 4.8 years, 323 total deaths, 81 cardiovascular deaths and 130 cancer deaths occurred. Nut consumption was associated with a significantly reduced risk of all-cause mortality (P for trend<0.05, all). Compared to non-consumers, subjects consuming nuts>3 servings/week (32% of the cohort) had a 39% lower mortality risk (hazard ratio (HR) 0.61; 95% CI 0.45 to 0.83). A similar protective effect against cardiovascular and cancer mortality was observed. Participants allocated to the Mediterranean diet with nuts group who consumed nuts>3 servings/week at baseline had the lowest total mortality risk (HR 0.37; 95% CI 0.22 to 0.66). CONCLUSIONS: Increased frequency of nut consumption was associated with a significantly reduced risk of mortality in a Mediterranean population at high cardiovascular risk.Please see related commentary: http://www.biomedcentral.com/1741-7015/11/165. TRIAL REGISTRATION: Clinicaltrials.gov. International Standard Randomized Controlled Trial Number (ISRCTN): 35739639. Registration date: 5 October 2005. SN - 1741-7015 UR - https://www.unboundmedicine.com/medline/citation/23866098/Frequency_of_nut_consumption_and_mortality_risk_in_the_PREDIMED_nutrition_intervention_trial_ L2 - https://bmcmedicine.biomedcentral.com/articles/10.1186/1741-7015-11-164 DB - PRIME DP - Unbound Medicine ER -