Tags

Type your tag names separated by a space and hit enter

Frequency of nut consumption and mortality risk in the PREDIMED nutrition intervention trial.
BMC Med 2013; 11:164BM

Abstract

BACKGROUND

Prospective studies in non-Mediterranean populations have consistently related increasing nut consumption to lower coronary heart disease mortality. A small protective effect on all-cause and cancer mortality has also been suggested. To examine the association between frequency of nut consumption and mortality in individuals at high cardiovascular risk from Spain, a Mediterranean country with a relatively high average nut intake per person.

METHODS

We evaluated 7,216 men and women aged 55 to 80 years randomized to 1 of 3 interventions (Mediterranean diets supplemented with nuts or olive oil and control diet) in the PREDIMED ('PREvención con DIeta MEDiterránea') study. Nut consumption was assessed at baseline and mortality was ascertained by medical records and linkage to the National Death Index. Multivariable-adjusted Cox regression and multivariable analyses with generalized estimating equation models were used to assess the association between yearly repeated measurements of nut consumption and mortality.

RESULTS

During a median follow-up of 4.8 years, 323 total deaths, 81 cardiovascular deaths and 130 cancer deaths occurred. Nut consumption was associated with a significantly reduced risk of all-cause mortality (P for trend<0.05, all). Compared to non-consumers, subjects consuming nuts>3 servings/week (32% of the cohort) had a 39% lower mortality risk (hazard ratio (HR) 0.61; 95% CI 0.45 to 0.83). A similar protective effect against cardiovascular and cancer mortality was observed. Participants allocated to the Mediterranean diet with nuts group who consumed nuts>3 servings/week at baseline had the lowest total mortality risk (HR 0.37; 95% CI 0.22 to 0.66).

CONCLUSIONS

Increased frequency of nut consumption was associated with a significantly reduced risk of mortality in a Mediterranean population at high cardiovascular risk.Please see related commentary: http://www.biomedcentral.com/1741-7015/11/165.

TRIAL REGISTRATION

Clinicaltrials.gov. International Standard Randomized Controlled Trial Number (ISRCTN): 35739639. Registration date: 5 October 2005.

Authors+Show Affiliations

Human Nutrition Unit, Hospital Universitari de Sant Joan de Reus, Faculty of Medicine and Health Sciences, IISPV (Institut d'Investigació Sanitària Pere Virgili), Universitat Rovira i Virgili, Reus, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23866098

Citation

Guasch-Ferré, Marta, et al. "Frequency of Nut Consumption and Mortality Risk in the PREDIMED Nutrition Intervention Trial." BMC Medicine, vol. 11, 2013, p. 164.
Guasch-Ferré M, Bulló M, Martínez-González MÁ, et al. Frequency of nut consumption and mortality risk in the PREDIMED nutrition intervention trial. BMC Med. 2013;11:164.
Guasch-Ferré, M., Bulló, M., Martínez-González, M. Á., Ros, E., Corella, D., Estruch, R., ... Salas-Salvadó, J. (2013). Frequency of nut consumption and mortality risk in the PREDIMED nutrition intervention trial. BMC Medicine, 11, p. 164. doi:10.1186/1741-7015-11-164.
Guasch-Ferré M, et al. Frequency of Nut Consumption and Mortality Risk in the PREDIMED Nutrition Intervention Trial. BMC Med. 2013 Jul 16;11:164. PubMed PMID: 23866098.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Frequency of nut consumption and mortality risk in the PREDIMED nutrition intervention trial. AU - Guasch-Ferré,Marta, AU - Bulló,Mònica, AU - Martínez-González,Miguel Ángel, AU - Ros,Emilio, AU - Corella,Dolores, AU - Estruch,Ramon, AU - Fitó,Montserrat, AU - Arós,Fernando, AU - Wärnberg,Julia, AU - Fiol,Miquel, AU - Lapetra,José, AU - Vinyoles,Ernest, AU - Lamuela-Raventós,Rosa Maria, AU - Serra-Majem,Lluís, AU - Pintó,Xavier, AU - Ruiz-Gutiérrez,Valentina, AU - Basora,Josep, AU - Salas-Salvadó,Jordi, AU - ,, Y1 - 2013/07/16/ PY - 2013/04/22/received PY - 2013/05/22/accepted PY - 2013/7/20/entrez PY - 2013/7/20/pubmed PY - 2014/2/5/medline SP - 164 EP - 164 JF - BMC medicine JO - BMC Med VL - 11 N2 - BACKGROUND: Prospective studies in non-Mediterranean populations have consistently related increasing nut consumption to lower coronary heart disease mortality. A small protective effect on all-cause and cancer mortality has also been suggested. To examine the association between frequency of nut consumption and mortality in individuals at high cardiovascular risk from Spain, a Mediterranean country with a relatively high average nut intake per person. METHODS: We evaluated 7,216 men and women aged 55 to 80 years randomized to 1 of 3 interventions (Mediterranean diets supplemented with nuts or olive oil and control diet) in the PREDIMED ('PREvención con DIeta MEDiterránea') study. Nut consumption was assessed at baseline and mortality was ascertained by medical records and linkage to the National Death Index. Multivariable-adjusted Cox regression and multivariable analyses with generalized estimating equation models were used to assess the association between yearly repeated measurements of nut consumption and mortality. RESULTS: During a median follow-up of 4.8 years, 323 total deaths, 81 cardiovascular deaths and 130 cancer deaths occurred. Nut consumption was associated with a significantly reduced risk of all-cause mortality (P for trend<0.05, all). Compared to non-consumers, subjects consuming nuts>3 servings/week (32% of the cohort) had a 39% lower mortality risk (hazard ratio (HR) 0.61; 95% CI 0.45 to 0.83). A similar protective effect against cardiovascular and cancer mortality was observed. Participants allocated to the Mediterranean diet with nuts group who consumed nuts>3 servings/week at baseline had the lowest total mortality risk (HR 0.37; 95% CI 0.22 to 0.66). CONCLUSIONS: Increased frequency of nut consumption was associated with a significantly reduced risk of mortality in a Mediterranean population at high cardiovascular risk.Please see related commentary: http://www.biomedcentral.com/1741-7015/11/165. TRIAL REGISTRATION: Clinicaltrials.gov. International Standard Randomized Controlled Trial Number (ISRCTN): 35739639. Registration date: 5 October 2005. SN - 1741-7015 UR - https://www.unboundmedicine.com/medline/citation/23866098/Frequency_of_nut_consumption_and_mortality_risk_in_the_PREDIMED_nutrition_intervention_trial_ L2 - https://bmcmedicine.biomedcentral.com/articles/10.1186/1741-7015-11-164 DB - PRIME DP - Unbound Medicine ER -