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A clinical manifestation-based prediction of haemodynamic patterns of orthostatic intolerance in children: a multi-centre study.
Cardiol Young. 2014 Aug; 24(4):649-53.CY

Abstract

OBJECTIVE

At present, the haemodynamic diagnosis of orthostatic intolerance is based mainly on the head-up tilt table test, which is sometimes risky for patients. Thus, it is important to find objective and safe methods to differentiate haemodynamic patterns of orthostatic intolerance cases.

METHODS

In all, 629 children with orthostatic intolerance, either vasovagal syncope or postural orthostatic tachycardia syndrome, were included in the multi-centre clinical study. We analysed the association between the clinical manifestation and haemodynamic patterns of the patients.

RESULTS

Syncope after motion with a prodrome of chest distress or palpitations and the concomitant symptom(s) after a syncopal attack, with debilitation, dizziness or headache, were the most important variables in predicting the diagnosis of vasovagal syncope. The overall diagnostic accuracy was 71.5%.

CONCLUSION

Complaint of syncope after motion with prodromal chest distress or palpitation and the concomitant symptom after a syncopal attack, with subsequent debilitation, dizziness or headache, were the most important variables in the diagnosis of vasovagal syncope in children with orthostatic intolerance.

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Authors+Show Affiliations

Chen L
1Department of Pediatrics,Peking University First Hospital,Beijing,China.
Li X
2Department of Statistics,Peking University First Hospital,Beijing,China.
Todd O
3Department of Pediatrics,Northwestern University Feinberg School of Medicine,Chicago,Illinois,United States ofAmerica.
Wang C
4The Second Hospital of Xiangya,Zhongnan University,Changsha,China.
Jin H
1Department of Pediatrics,Peking University First Hospital,Beijing,China.
Du J
1Department of Pediatrics,Peking University First Hospital,Beijing,China.

MeSH

AdolescentBlood PressureChest PainChildChild, PreschoolDiscriminant AnalysisDizzinessFemaleHeadacheHeart RateHemodynamicsHot TemperatureHumansMaleMedical History TakingNauseaNitroglycerinOrthostatic IntolerancePostural Orthostatic Tachycardia SyndromeProdromal SymptomsSensitivity and SpecificitySupine PositionSyncope, VasovagalTilt-Table TestVasodilator AgentsVomiting

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23866994

Citation

Chen, Li, et al. "A Clinical Manifestation-based Prediction of Haemodynamic Patterns of Orthostatic Intolerance in Children: a Multi-centre Study." Cardiology in the Young, vol. 24, no. 4, 2014, pp. 649-53.
Chen L, Li X, Todd O, et al. A clinical manifestation-based prediction of haemodynamic patterns of orthostatic intolerance in children: a multi-centre study. Cardiol Young. 2014;24(4):649-53.
Chen, L., Li, X., Todd, O., Wang, C., Jin, H., & Du, J. (2014). A clinical manifestation-based prediction of haemodynamic patterns of orthostatic intolerance in children: a multi-centre study. Cardiology in the Young, 24(4), 649-53. https://doi.org/10.1017/S1047951113000929
Chen L, et al. A Clinical Manifestation-based Prediction of Haemodynamic Patterns of Orthostatic Intolerance in Children: a Multi-centre Study. Cardiol Young. 2014;24(4):649-53. PubMed PMID: 23866994.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A clinical manifestation-based prediction of haemodynamic patterns of orthostatic intolerance in children: a multi-centre study. AU - Chen,Li, AU - Li,Xueying, AU - Todd,Ochs, AU - Wang,Cheng, AU - Jin,Hongfang, AU - Du,Junbao, Y1 - 2013/07/18/ PY - 2013/7/23/entrez PY - 2013/7/23/pubmed PY - 2015/2/14/medline SP - 649 EP - 53 JF - Cardiology in the young JO - Cardiol Young VL - 24 IS - 4 N2 - OBJECTIVE: At present, the haemodynamic diagnosis of orthostatic intolerance is based mainly on the head-up tilt table test, which is sometimes risky for patients. Thus, it is important to find objective and safe methods to differentiate haemodynamic patterns of orthostatic intolerance cases. METHODS: In all, 629 children with orthostatic intolerance, either vasovagal syncope or postural orthostatic tachycardia syndrome, were included in the multi-centre clinical study. We analysed the association between the clinical manifestation and haemodynamic patterns of the patients. RESULTS: Syncope after motion with a prodrome of chest distress or palpitations and the concomitant symptom(s) after a syncopal attack, with debilitation, dizziness or headache, were the most important variables in predicting the diagnosis of vasovagal syncope. The overall diagnostic accuracy was 71.5%. CONCLUSION: Complaint of syncope after motion with prodromal chest distress or palpitation and the concomitant symptom after a syncopal attack, with subsequent debilitation, dizziness or headache, were the most important variables in the diagnosis of vasovagal syncope in children with orthostatic intolerance. SN - 1467-1107 UR - https://www.unboundmedicine.com/medline/citation/23866994/A_clinical_manifestation_based_prediction_of_haemodynamic_patterns_of_orthostatic_intolerance_in_children:_a_multi_centre_study_ L2 - https://www.cambridge.org/core/product/identifier/S1047951113000929/type/journal_article DB - PRIME DP - Unbound Medicine ER -