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Effects of dietary supplementation of coriander oil, in canola oil diets, on the metabolism of [1-(14)C] 18:3n-3 and [1-(14)C] 18:2n-6 in rainbow trout hepatocytes.
Comp Biochem Physiol B Biochem Mol Biol. 2013 Sep; 166(1):65-72.CB

Abstract

The aim of this study was to investigate the effects of petroselinic acid, found in coriander oil, on the ability of rainbow trout hepatocytes to increase the production of eicosapentaenoic acid (20:5n-3; EPA) and docosahexaenoic acid (22:6n-3; DHA) from [1-(14)C] α-linolenic acid (18:3n-3; ALA) and to reduce the production of arachidonic acid (20:4n-6; ARA) from [1-(14)C] 18:2n-6. Addition of coriander oil increased the production of 22:6n-3, from [1-(14)C] 18:3n-3, at the 0.5 and 1.0% inclusion levels and reduced the conversion of [1-(14)C] 18:2n-6 to 20:4n-6. β-Oxidation was significantly increased at the 1.5% inclusion level for [1-(14)C] 18:2n-6, however β-oxidation for [1-(14)C] 18:3n-3 only showed an increasing trend. Acetate, a main breakdown product of fatty acids (FA) via peroxisomal β-oxidation, decreased three-fold for [1-(14)C] 18:2n-6 and nearly doubled for [1-(14)C] 18:3n-3 when coriander was added at a 1.5% inclusion level. Acyl coenzyme A oxidase (ACO) enzyme activity showed no significant differences between treatments. Relative gene expression of ∆6 desaturase decreased with addition of coriander oil compared to the control. The addition of petroselinic acid via coriander oil to vegetable oil (VO) based diets containing no fishmeal (FM) or fish oil (FO), significantly increased the production of anti-inflammatory precursor 22:6n-3 (P=0.011) and decreased pro-inflammatory precursor 20:4n-6 (P=0.023) in radiolabelled hepatocytes of rainbow trout.

Authors+Show Affiliations

Department of Animal and Poultry Science, University of Saskatchewan, 51 Campus Drive, Saskatoon, SK S7N 5A8, Canada. kyla.zatti@usask.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23867781

Citation

Randall, K M., et al. "Effects of Dietary Supplementation of Coriander Oil, in Canola Oil Diets, On the Metabolism of [1-(14)C] 18:3n-3 and [1-(14)C] 18:2n-6 in Rainbow Trout Hepatocytes." Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology, vol. 166, no. 1, 2013, pp. 65-72.
Randall KM, Drew MD, Øverland M, et al. Effects of dietary supplementation of coriander oil, in canola oil diets, on the metabolism of [1-(14)C] 18:3n-3 and [1-(14)C] 18:2n-6 in rainbow trout hepatocytes. Comp Biochem Physiol B, Biochem Mol Biol. 2013;166(1):65-72.
Randall, K. M., Drew, M. D., Øverland, M., Østbye, T. K., Bjerke, M., Vogt, G., & Ruyter, B. (2013). Effects of dietary supplementation of coriander oil, in canola oil diets, on the metabolism of [1-(14)C] 18:3n-3 and [1-(14)C] 18:2n-6 in rainbow trout hepatocytes. Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology, 166(1), 65-72. https://doi.org/10.1016/j.cbpb.2013.07.004
Randall KM, et al. Effects of Dietary Supplementation of Coriander Oil, in Canola Oil Diets, On the Metabolism of [1-(14)C] 18:3n-3 and [1-(14)C] 18:2n-6 in Rainbow Trout Hepatocytes. Comp Biochem Physiol B, Biochem Mol Biol. 2013;166(1):65-72. PubMed PMID: 23867781.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of dietary supplementation of coriander oil, in canola oil diets, on the metabolism of [1-(14)C] 18:3n-3 and [1-(14)C] 18:2n-6 in rainbow trout hepatocytes. AU - Randall,K M, AU - Drew,M D, AU - Øverland,M, AU - Østbye,T-K, AU - Bjerke,M, AU - Vogt,G, AU - Ruyter,B, Y1 - 2013/07/16/ PY - 2013/03/19/received PY - 2013/07/08/revised PY - 2013/07/10/accepted PY - 2013/7/23/entrez PY - 2013/7/23/pubmed PY - 2014/3/19/medline KW - ACO KW - ALA KW - ARA KW - ASP KW - Acid soluble products KW - Arachidonic acid KW - BSA KW - CP KW - CPT1 KW - Carnitine palmitoyl transferase I KW - Coriander oil KW - DHA KW - Delta 5 desaturase KW - Delta 6 desaturase KW - Docosahexaenoic acid KW - EDTA KW - EF1A KW - EPA KW - ETIF3 KW - FA KW - FBS KW - FFA KW - FM KW - FO KW - HEPES KW - Hepatocytes KW - LA KW - LC-PUFA KW - Long chain polyunsaturated fatty acids KW - MG KW - MUFA KW - Monoglycerides KW - Monounsaturated fatty acids KW - PBS KW - PL KW - PUFA KW - Rainbow trout KW - SFA KW - Saturated fatty acids KW - TAG KW - TLC KW - Triacylglyerols KW - VO KW - Vegetable oil KW - acyl coenzyme A oxidase KW - arachidonic acid KW - bovine serum albumin KW - crude protein KW - docosahexaenoic acid KW - eicosapentaenoic acid KW - elongation factor 1a KW - ethylenediaminetetraacetic acid KW - eukaryotic translation initiation factor 3 KW - fatty acid KW - fish oil KW - fishmeal KW - foetal bovine serum KW - free fatty acids KW - linoleic acid KW - phenylethylamine and 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid KW - phosphate buffer saline KW - phospholipids KW - polyunsaturated fatty acids KW - thin-layer chromatography KW - α-linolenic acid KW - ∆5 KW - ∆6 SP - 65 EP - 72 JF - Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology JO - Comp. Biochem. Physiol. B, Biochem. Mol. Biol. VL - 166 IS - 1 N2 - The aim of this study was to investigate the effects of petroselinic acid, found in coriander oil, on the ability of rainbow trout hepatocytes to increase the production of eicosapentaenoic acid (20:5n-3; EPA) and docosahexaenoic acid (22:6n-3; DHA) from [1-(14)C] α-linolenic acid (18:3n-3; ALA) and to reduce the production of arachidonic acid (20:4n-6; ARA) from [1-(14)C] 18:2n-6. Addition of coriander oil increased the production of 22:6n-3, from [1-(14)C] 18:3n-3, at the 0.5 and 1.0% inclusion levels and reduced the conversion of [1-(14)C] 18:2n-6 to 20:4n-6. β-Oxidation was significantly increased at the 1.5% inclusion level for [1-(14)C] 18:2n-6, however β-oxidation for [1-(14)C] 18:3n-3 only showed an increasing trend. Acetate, a main breakdown product of fatty acids (FA) via peroxisomal β-oxidation, decreased three-fold for [1-(14)C] 18:2n-6 and nearly doubled for [1-(14)C] 18:3n-3 when coriander was added at a 1.5% inclusion level. Acyl coenzyme A oxidase (ACO) enzyme activity showed no significant differences between treatments. Relative gene expression of ∆6 desaturase decreased with addition of coriander oil compared to the control. The addition of petroselinic acid via coriander oil to vegetable oil (VO) based diets containing no fishmeal (FM) or fish oil (FO), significantly increased the production of anti-inflammatory precursor 22:6n-3 (P=0.011) and decreased pro-inflammatory precursor 20:4n-6 (P=0.023) in radiolabelled hepatocytes of rainbow trout. SN - 1879-1107 UR - https://www.unboundmedicine.com/medline/citation/23867781/Effects_of_dietary_supplementation_of_coriander_oil_in_canola_oil_diets_on_the_metabolism_of_[1__14_C]_18:3n_3_and_[1__14_C]_18:2n_6_in_rainbow_trout_hepatocytes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1096-4959(13)00118-8 DB - PRIME DP - Unbound Medicine ER -