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Time-varying coupling of EEG oscillations predicts excitability fluctuations in the primary motor cortex as reflected by motor evoked potentials amplitude: an EEG-TMS study.
Hum Brain Mapp 2014; 35(5):1969-80HB

Abstract

PURPOSE

Motor evoked potentials (MEPs) elicited by a train of consecutive, individual transcranial magnetic stimuli demonstrate fluctuations in amplitude with respect to time when recorded from a relaxed muscle. The influence of time-varying, instantaneous modifications of the electroencephalography (EEG) properties immediately preceding the transcranial magnetic stimulation (TMS) has rarely been explored. The aim of this study was to investigate the influence of the pre-TMS motor cortex and related areas EEG profile on time variants of the MEPs amplitude.

METHOD

MRI-navigated TMS and multichannel TMS-compatible EEG devices were used. For each experimental subject, post-hoc analysis of the MEPs amplitude that was based on the 50th percentile of the MEPs amplitude distribution provided two subgroups corresponding to "high" (large amplitude) and "low" (small amplitude). The pre-stimulus EEG characteristics (coherence and spectral profile) from the motor cortex and related areas were analyzed separately for the "high" and "low" MEPs and were then compared.

RESULTS

On the stimulated hemisphere, EEG coupling was observed more often in the high compared to the low MEP trials. Moreover, a paradigmatic pattern in which TMS was able to lead to significantly larger MEPs was found when the EEG of the stimulated motor cortex was coupled in the beta 2 band with the ipsilateral prefrontal cortex and in the delta band with the bilateral centro-parietal-occipital cortices.

CONCLUSION

This data provide evidence for a statistically significant influence of time-varying and spatially patterned synchronization of EEG rhythms in determining cortical excitability, namely motor cortex excitability in response to TMS.

Authors+Show Affiliations

Department of Neurology, University Campus Biomedico, Rome, Italy; Department of Clinical Neurophysiology, Kuopio University Hospital, University of Eastern Finland, Kuopio, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23868714

Citation

Ferreri, Florinda, et al. "Time-varying Coupling of EEG Oscillations Predicts Excitability Fluctuations in the Primary Motor Cortex as Reflected By Motor Evoked Potentials Amplitude: an EEG-TMS Study." Human Brain Mapping, vol. 35, no. 5, 2014, pp. 1969-80.
Ferreri F, Vecchio F, Ponzo D, et al. Time-varying coupling of EEG oscillations predicts excitability fluctuations in the primary motor cortex as reflected by motor evoked potentials amplitude: an EEG-TMS study. Hum Brain Mapp. 2014;35(5):1969-80.
Ferreri, F., Vecchio, F., Ponzo, D., Pasqualetti, P., & Rossini, P. M. (2014). Time-varying coupling of EEG oscillations predicts excitability fluctuations in the primary motor cortex as reflected by motor evoked potentials amplitude: an EEG-TMS study. Human Brain Mapping, 35(5), pp. 1969-80. doi:10.1002/hbm.22306.
Ferreri F, et al. Time-varying Coupling of EEG Oscillations Predicts Excitability Fluctuations in the Primary Motor Cortex as Reflected By Motor Evoked Potentials Amplitude: an EEG-TMS Study. Hum Brain Mapp. 2014;35(5):1969-80. PubMed PMID: 23868714.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Time-varying coupling of EEG oscillations predicts excitability fluctuations in the primary motor cortex as reflected by motor evoked potentials amplitude: an EEG-TMS study. AU - Ferreri,Florinda, AU - Vecchio,Fabrizio, AU - Ponzo,David, AU - Pasqualetti,Patrizio, AU - Rossini,Paolo Maria, Y1 - 2013/07/19/ PY - 2012/07/17/received PY - 2013/03/03/revised PY - 2013/03/28/accepted PY - 2013/7/23/entrez PY - 2013/7/23/pubmed PY - 2014/12/15/medline KW - EEG KW - EEG coherence KW - EEG-TMS coregistration KW - cortical connectivity KW - navigated transcranial magnetic stimulation SP - 1969 EP - 80 JF - Human brain mapping JO - Hum Brain Mapp VL - 35 IS - 5 N2 - PURPOSE: Motor evoked potentials (MEPs) elicited by a train of consecutive, individual transcranial magnetic stimuli demonstrate fluctuations in amplitude with respect to time when recorded from a relaxed muscle. The influence of time-varying, instantaneous modifications of the electroencephalography (EEG) properties immediately preceding the transcranial magnetic stimulation (TMS) has rarely been explored. The aim of this study was to investigate the influence of the pre-TMS motor cortex and related areas EEG profile on time variants of the MEPs amplitude. METHOD: MRI-navigated TMS and multichannel TMS-compatible EEG devices were used. For each experimental subject, post-hoc analysis of the MEPs amplitude that was based on the 50th percentile of the MEPs amplitude distribution provided two subgroups corresponding to "high" (large amplitude) and "low" (small amplitude). The pre-stimulus EEG characteristics (coherence and spectral profile) from the motor cortex and related areas were analyzed separately for the "high" and "low" MEPs and were then compared. RESULTS: On the stimulated hemisphere, EEG coupling was observed more often in the high compared to the low MEP trials. Moreover, a paradigmatic pattern in which TMS was able to lead to significantly larger MEPs was found when the EEG of the stimulated motor cortex was coupled in the beta 2 band with the ipsilateral prefrontal cortex and in the delta band with the bilateral centro-parietal-occipital cortices. CONCLUSION: This data provide evidence for a statistically significant influence of time-varying and spatially patterned synchronization of EEG rhythms in determining cortical excitability, namely motor cortex excitability in response to TMS. SN - 1097-0193 UR - https://www.unboundmedicine.com/medline/citation/23868714/Time_varying_coupling_of_EEG_oscillations_predicts_excitability_fluctuations_in_the_primary_motor_cortex_as_reflected_by_motor_evoked_potentials_amplitude:_an_EEG_TMS_study_ L2 - https://doi.org/10.1002/hbm.22306 DB - PRIME DP - Unbound Medicine ER -