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Prevalence of 25-hydroxyvitamin D deficiency in child and adolescent patients undergoing hematopoietic cell transplantation compared to a healthy population.
Pediatr Blood Cancer. 2013 Dec; 60(12):2025-30.PB

Abstract

BACKGROUND

Pediatric patients undergoing allogeneic hematopoietic cell transplant (HCT) are at risk for low bone mineral density, which may due, in part, to low 25-hydroxyvitamin D levels.

PROCEDURE

We compared the serum 25-hydroxyvitamin D status of 22 pediatric HCT patients with 100 healthy pediatric controls. We determined the prevalence of and risk factors for 25-hydroxyvitamin D insufficiency and deficiency.

RESULTS

Serum 25-hydroxyvitamin D levels were lower in the pediatric HCT patients at time of transplant than healthy pediatric controls (median 19.5 ng/ml vs. 31.0 ng/ml, P < 0.001). Of HCT patients, 27% were 25-hydroxyvitamin D deficient (<15 ng/dl) and 68% insufficient (15-29 ng/dl), compared with 4% and 40%, respectively, of healthy pediatric controls (P < 0.001). In multivariable analysis, treatment with HCT, decreased ambient ultraviolet light exposure, non-Caucasian race, and older age were associated with decreased serum 25-hydroxyvitamin D levels. No association was found between 25-hydroxyvitamin D levels and gender, body mass index, dietary vitamin D intake, or patient-reported vitamin D supplementation. Few patients in either group reported sunscreen use, vitamin D supplementation, or recommended dietary vitamin D intake.

CONCLUSIONS

At time of transplant, pediatric HCT patients frequently have 25-hydroxyvitamin D insufficiency/deficiency, and this occurs more commonly than in the healthy pediatric population. HCT patients rarely follow recommended guidelines to take supplemental vitamin D, consume the Recommended Daily Allowance for vitamin D, or regularly use sunscreen. Further studies are needed to determine whether vitamin D insufficiency/deficiency persists long term in HCT patients and requires dietary and behavioral interventions.

Authors+Show Affiliations

Department of Pediatrics, Division of Endocrinology and Diabetes, Vanderbilt University School of Medicine, Nashville, Tennessee.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

23868793

Citation

Simmons, Jill, et al. "Prevalence of 25-hydroxyvitamin D Deficiency in Child and Adolescent Patients Undergoing Hematopoietic Cell Transplantation Compared to a Healthy Population." Pediatric Blood & Cancer, vol. 60, no. 12, 2013, pp. 2025-30.
Simmons J, Sheedy C, Lee H, et al. Prevalence of 25-hydroxyvitamin D deficiency in child and adolescent patients undergoing hematopoietic cell transplantation compared to a healthy population. Pediatr Blood Cancer. 2013;60(12):2025-30.
Simmons, J., Sheedy, C., Lee, H., Koh, S., Alvarez, J., Koyama, T., & Friedman, D. (2013). Prevalence of 25-hydroxyvitamin D deficiency in child and adolescent patients undergoing hematopoietic cell transplantation compared to a healthy population. Pediatric Blood & Cancer, 60(12), 2025-30. https://doi.org/10.1002/pbc.24684
Simmons J, et al. Prevalence of 25-hydroxyvitamin D Deficiency in Child and Adolescent Patients Undergoing Hematopoietic Cell Transplantation Compared to a Healthy Population. Pediatr Blood Cancer. 2013;60(12):2025-30. PubMed PMID: 23868793.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of 25-hydroxyvitamin D deficiency in child and adolescent patients undergoing hematopoietic cell transplantation compared to a healthy population. AU - Simmons,Jill, AU - Sheedy,Craig, AU - Lee,Haerin, AU - Koh,Shannon, AU - Alvarez,Joann, AU - Koyama,Tatsuki, AU - Friedman,Debra, Y1 - 2013/07/19/ PY - 2013/05/06/received PY - 2013/06/12/accepted PY - 2013/7/23/entrez PY - 2013/7/23/pubmed PY - 2013/12/16/medline KW - hematopoietic stem cell transplantation KW - pediatric KW - vitamin D deficiency KW - vitamin D insufficiency SP - 2025 EP - 30 JF - Pediatric blood & cancer JO - Pediatr Blood Cancer VL - 60 IS - 12 N2 - BACKGROUND: Pediatric patients undergoing allogeneic hematopoietic cell transplant (HCT) are at risk for low bone mineral density, which may due, in part, to low 25-hydroxyvitamin D levels. PROCEDURE: We compared the serum 25-hydroxyvitamin D status of 22 pediatric HCT patients with 100 healthy pediatric controls. We determined the prevalence of and risk factors for 25-hydroxyvitamin D insufficiency and deficiency. RESULTS: Serum 25-hydroxyvitamin D levels were lower in the pediatric HCT patients at time of transplant than healthy pediatric controls (median 19.5 ng/ml vs. 31.0 ng/ml, P < 0.001). Of HCT patients, 27% were 25-hydroxyvitamin D deficient (<15 ng/dl) and 68% insufficient (15-29 ng/dl), compared with 4% and 40%, respectively, of healthy pediatric controls (P < 0.001). In multivariable analysis, treatment with HCT, decreased ambient ultraviolet light exposure, non-Caucasian race, and older age were associated with decreased serum 25-hydroxyvitamin D levels. No association was found between 25-hydroxyvitamin D levels and gender, body mass index, dietary vitamin D intake, or patient-reported vitamin D supplementation. Few patients in either group reported sunscreen use, vitamin D supplementation, or recommended dietary vitamin D intake. CONCLUSIONS: At time of transplant, pediatric HCT patients frequently have 25-hydroxyvitamin D insufficiency/deficiency, and this occurs more commonly than in the healthy pediatric population. HCT patients rarely follow recommended guidelines to take supplemental vitamin D, consume the Recommended Daily Allowance for vitamin D, or regularly use sunscreen. Further studies are needed to determine whether vitamin D insufficiency/deficiency persists long term in HCT patients and requires dietary and behavioral interventions. SN - 1545-5017 UR - https://www.unboundmedicine.com/medline/citation/23868793/Prevalence_of_25_hydroxyvitamin_D_deficiency_in_child_and_adolescent_patients_undergoing_hematopoietic_cell_transplantation_compared_to_a_healthy_population_ L2 - https://doi.org/10.1002/pbc.24684 DB - PRIME DP - Unbound Medicine ER -