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Pandoraviruses: amoeba viruses with genomes up to 2.5 Mb reaching that of parasitic eukaryotes.
Science. 2013 Jul 19; 341(6143):281-6.Sci

Abstract

Ten years ago, the discovery of Mimivirus, a virus infecting Acanthamoeba, initiated a reappraisal of the upper limits of the viral world, both in terms of particle size (>0.7 micrometers) and genome complexity (>1000 genes), dimensions typical of parasitic bacteria. The diversity of these giant viruses (the Megaviridae) was assessed by sampling a variety of aquatic environments and their associated sediments worldwide. We report the isolation of two giant viruses, one off the coast of central Chile, the other from a freshwater pond near Melbourne (Australia), without morphological or genomic resemblance to any previously defined virus families. Their micrometer-sized ovoid particles contain DNA genomes of at least 2.5 and 1.9 megabases, respectively. These viruses are the first members of the proposed "Pandoravirus" genus, a term reflecting their lack of similarity with previously described microorganisms and the surprises expected from their future study.

Authors+Show Affiliations

Structural and Genomic Information Laboratory, UMR 7256 CNRS Aix-Marseille Université, 163 Avenue de Luminy, Case 934, 13288 Marseille cedex 9, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23869018

Citation

Philippe, Nadège, et al. "Pandoraviruses: Amoeba Viruses With Genomes Up to 2.5 Mb Reaching That of Parasitic Eukaryotes." Science (New York, N.Y.), vol. 341, no. 6143, 2013, pp. 281-6.
Philippe N, Legendre M, Doutre G, et al. Pandoraviruses: amoeba viruses with genomes up to 2.5 Mb reaching that of parasitic eukaryotes. Science. 2013;341(6143):281-6.
Philippe, N., Legendre, M., Doutre, G., Couté, Y., Poirot, O., Lescot, M., Arslan, D., Seltzer, V., Bertaux, L., Bruley, C., Garin, J., Claverie, J. M., & Abergel, C. (2013). Pandoraviruses: amoeba viruses with genomes up to 2.5 Mb reaching that of parasitic eukaryotes. Science (New York, N.Y.), 341(6143), 281-6. https://doi.org/10.1126/science.1239181
Philippe N, et al. Pandoraviruses: Amoeba Viruses With Genomes Up to 2.5 Mb Reaching That of Parasitic Eukaryotes. Science. 2013 Jul 19;341(6143):281-6. PubMed PMID: 23869018.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pandoraviruses: amoeba viruses with genomes up to 2.5 Mb reaching that of parasitic eukaryotes. AU - Philippe,Nadège, AU - Legendre,Matthieu, AU - Doutre,Gabriel, AU - Couté,Yohann, AU - Poirot,Olivier, AU - Lescot,Magali, AU - Arslan,Defne, AU - Seltzer,Virginie, AU - Bertaux,Lionel, AU - Bruley,Christophe, AU - Garin,Jérome, AU - Claverie,Jean-Michel, AU - Abergel,Chantal, PY - 2013/7/23/entrez PY - 2013/7/23/pubmed PY - 2013/8/7/medline SP - 281 EP - 6 JF - Science (New York, N.Y.) JO - Science VL - 341 IS - 6143 N2 - Ten years ago, the discovery of Mimivirus, a virus infecting Acanthamoeba, initiated a reappraisal of the upper limits of the viral world, both in terms of particle size (>0.7 micrometers) and genome complexity (>1000 genes), dimensions typical of parasitic bacteria. The diversity of these giant viruses (the Megaviridae) was assessed by sampling a variety of aquatic environments and their associated sediments worldwide. We report the isolation of two giant viruses, one off the coast of central Chile, the other from a freshwater pond near Melbourne (Australia), without morphological or genomic resemblance to any previously defined virus families. Their micrometer-sized ovoid particles contain DNA genomes of at least 2.5 and 1.9 megabases, respectively. These viruses are the first members of the proposed "Pandoravirus" genus, a term reflecting their lack of similarity with previously described microorganisms and the surprises expected from their future study. SN - 1095-9203 UR - https://www.unboundmedicine.com/medline/citation/23869018/Pandoraviruses:_amoeba_viruses_with_genomes_up_to_2_5_Mb_reaching_that_of_parasitic_eukaryotes_ L2 - https://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=23869018 DB - PRIME DP - Unbound Medicine ER -