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Limonoid constituents of Euodia rutaecarpa var. bodinieri and their inhibition on NO production in lipopolysaccharide-activated RAW264.7 macrophages.
J Asian Nat Prod Res. 2013; 15(10):1130-8.JA

Abstract

A new limonoid compound, named evorubodinin (1), was isolated from the dried and nearly ripe fruits of Euodia rutaecarpa (Juss.) Benth. var. bodinieri (Dode) Huang (family Rutaceae), together with two known limonoid compounds, limonin (2) and evolimorutanin (3). The chemical structure of 1 was elucidated by spectroscopic method and single-crystal X-ray diffraction. The inhibitory effects of the isolated compounds 1-3 and the structurally related compounds evodol (4), shihulimonin A1 (5), evodirutaenin (6), 12α-hydroxyrutaevin (7), and rutaevin (8) on nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophages were also assayed. All compounds 1-8 showed the inhibitory activity, in which both 7 and 8 with the uncommon 5β-H configuration more efficiently inhibited NO production. The results provided valuable information for further investigation of compounds 1-8 as anti-inflammatory agents or lead compounds.

Authors+Show Affiliations

a Beijing University of Chinese Medicines , Beijing , 100029 , China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23869424

Citation

Yang, Xin-Bao, et al. "Limonoid Constituents of Euodia Rutaecarpa Var. Bodinieri and Their Inhibition On NO Production in Lipopolysaccharide-activated RAW264.7 Macrophages." Journal of Asian Natural Products Research, vol. 15, no. 10, 2013, pp. 1130-8.
Yang XB, Qian P, Yang XW, et al. Limonoid constituents of Euodia rutaecarpa var. bodinieri and their inhibition on NO production in lipopolysaccharide-activated RAW264.7 macrophages. J Asian Nat Prod Res. 2013;15(10):1130-8.
Yang, X. B., Qian, P., Yang, X. W., Liu, J. X., Gong, N. B., & Lv, Y. (2013). Limonoid constituents of Euodia rutaecarpa var. bodinieri and their inhibition on NO production in lipopolysaccharide-activated RAW264.7 macrophages. Journal of Asian Natural Products Research, 15(10), 1130-8. https://doi.org/10.1080/10286020.2013.817392
Yang XB, et al. Limonoid Constituents of Euodia Rutaecarpa Var. Bodinieri and Their Inhibition On NO Production in Lipopolysaccharide-activated RAW264.7 Macrophages. J Asian Nat Prod Res. 2013;15(10):1130-8. PubMed PMID: 23869424.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Limonoid constituents of Euodia rutaecarpa var. bodinieri and their inhibition on NO production in lipopolysaccharide-activated RAW264.7 macrophages. AU - Yang,Xin-Bao, AU - Qian,Ping, AU - Yang,Xiu-Wei, AU - Liu,Jian-Xun, AU - Gong,Ning-Bo, AU - Lv,Yang, Y1 - 2013/07/22/ PY - 2013/7/23/entrez PY - 2013/7/23/pubmed PY - 2014/1/31/medline SP - 1130 EP - 8 JF - Journal of Asian natural products research JO - J Asian Nat Prod Res VL - 15 IS - 10 N2 - A new limonoid compound, named evorubodinin (1), was isolated from the dried and nearly ripe fruits of Euodia rutaecarpa (Juss.) Benth. var. bodinieri (Dode) Huang (family Rutaceae), together with two known limonoid compounds, limonin (2) and evolimorutanin (3). The chemical structure of 1 was elucidated by spectroscopic method and single-crystal X-ray diffraction. The inhibitory effects of the isolated compounds 1-3 and the structurally related compounds evodol (4), shihulimonin A1 (5), evodirutaenin (6), 12α-hydroxyrutaevin (7), and rutaevin (8) on nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophages were also assayed. All compounds 1-8 showed the inhibitory activity, in which both 7 and 8 with the uncommon 5β-H configuration more efficiently inhibited NO production. The results provided valuable information for further investigation of compounds 1-8 as anti-inflammatory agents or lead compounds. SN - 1477-2213 UR - https://www.unboundmedicine.com/medline/citation/23869424/Limonoid_constituents_of_Euodia_rutaecarpa_var__bodinieri_and_their_inhibition_on_NO_production_in_lipopolysaccharide_activated_RAW264_7_macrophages_ L2 - https://www.tandfonline.com/doi/full/10.1080/10286020.2013.817392 DB - PRIME DP - Unbound Medicine ER -