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Prenatal and early childhood bisphenol A concentrations and behavior in school-aged children.
Environ Res. 2013 Oct; 126:43-50.ER

Abstract

INTRODUCTION

Early life exposure to bisphenol A (BPA), an endocrine disrupting chemical used in some food and beverage containers, receipts, and dental sealants, has been associated with anxiety and hyperactivity in animal studies. A few human studies also show prenatal and childhood BPA exposure to be associated with behavior problems in children.

METHODS

We measured BPA in urine from mothers during pregnancy and children at 5 years of age (N=292). Child behavior was assessed by mother and teacher report at age 7 years and direct assessment at age 9 years.

RESULTS

Prenatal urinary BPA concentrations were associated with increased internalizing problems in boys, including anxiety and depression, at age 7. No associations were seen with prenatal BPA concentrations and behaviors in girls. Childhood urinary BPA concentrations were associated with increased externalizing behaviors, including conduct problems, in girls at age 7 and increased internalizing behaviors and inattention and hyperactivity behaviors in boys and girls at age 7.

CONCLUSIONS

This study adds to the existing literature showing associations of early life BPA exposure with behavior problems, including anxiety, depression, and hyperactivity in children. Additional information about timing of exposure and sex differences in effect is still needed.

Authors+Show Affiliations

Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, 1995 University Ave., Suite 265, Berkeley, CA 94704, USA. Electronic address: kharley@berkeley.edu.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

23870093

Citation

Harley, Kim G., et al. "Prenatal and Early Childhood Bisphenol a Concentrations and Behavior in School-aged Children." Environmental Research, vol. 126, 2013, pp. 43-50.
Harley KG, Gunier RB, Kogut K, et al. Prenatal and early childhood bisphenol A concentrations and behavior in school-aged children. Environ Res. 2013;126:43-50.
Harley, K. G., Gunier, R. B., Kogut, K., Johnson, C., Bradman, A., Calafat, A. M., & Eskenazi, B. (2013). Prenatal and early childhood bisphenol A concentrations and behavior in school-aged children. Environmental Research, 126, 43-50. https://doi.org/10.1016/j.envres.2013.06.004
Harley KG, et al. Prenatal and Early Childhood Bisphenol a Concentrations and Behavior in School-aged Children. Environ Res. 2013;126:43-50. PubMed PMID: 23870093.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal and early childhood bisphenol A concentrations and behavior in school-aged children. AU - Harley,Kim G, AU - Gunier,Robert B, AU - Kogut,Katherine, AU - Johnson,Caroline, AU - Bradman,Asa, AU - Calafat,Antonia M, AU - Eskenazi,Brenda, Y1 - 2013/07/17/ PY - 2013/01/24/received PY - 2013/05/20/revised PY - 2013/06/13/accepted PY - 2013/7/23/entrez PY - 2013/7/23/pubmed PY - 2014/8/13/medline KW - ADHD KW - Anxiety KW - Behavior KW - Bisphenol A KW - Children KW - Depression SP - 43 EP - 50 JF - Environmental research JO - Environ. Res. VL - 126 N2 - INTRODUCTION: Early life exposure to bisphenol A (BPA), an endocrine disrupting chemical used in some food and beverage containers, receipts, and dental sealants, has been associated with anxiety and hyperactivity in animal studies. A few human studies also show prenatal and childhood BPA exposure to be associated with behavior problems in children. METHODS: We measured BPA in urine from mothers during pregnancy and children at 5 years of age (N=292). Child behavior was assessed by mother and teacher report at age 7 years and direct assessment at age 9 years. RESULTS: Prenatal urinary BPA concentrations were associated with increased internalizing problems in boys, including anxiety and depression, at age 7. No associations were seen with prenatal BPA concentrations and behaviors in girls. Childhood urinary BPA concentrations were associated with increased externalizing behaviors, including conduct problems, in girls at age 7 and increased internalizing behaviors and inattention and hyperactivity behaviors in boys and girls at age 7. CONCLUSIONS: This study adds to the existing literature showing associations of early life BPA exposure with behavior problems, including anxiety, depression, and hyperactivity in children. Additional information about timing of exposure and sex differences in effect is still needed. SN - 1096-0953 UR - https://www.unboundmedicine.com/medline/citation/23870093/Prenatal_and_early_childhood_bisphenol_A_concentrations_and_behavior_in_school_aged_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0013-9351(13)00112-6 DB - PRIME DP - Unbound Medicine ER -