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Comparison of the Montreal Cognitive Assessment and the Mini-Mental State Examination in detecting multi-domain mild cognitive impairment in a Chinese sub-sample drawn from a population-based study.
Int Psychogeriatr. 2013 Nov; 25(11):1831-8.IP

Abstract

BACKGROUND

We examined the discriminant validity of the Montreal Cognitive Assessment (MoCA) and the Mini-Mental State Examination (MMSE) in detecting multiple-domain mild cognitive impairment (md-MCI) in a Chinese sub-sample drawn from elderly population-based study.

METHODS

This study included Chinese participants from the Epidemiology of Dementia in Singapore (EDIS) study aged ≥ 60 years who underwent cognitive screening with the Abbreviated Mental Test and Progressive Forgetfulness Questionnaire. Screen-positive participants subsequently underwent MoCA, MMSE, and a comprehensive formal neuropsychological battery. MCI was defined by Petersen's criteria and further classified into single-domain MCI (sd-MCI) and md-MCI. Area under the receiver operating characteristic curve (AUC) with 95% confidence intervals (CIs) was computed for the MoCA and the MMSE in detecting md-MCI.

RESULTS

A total of 300 participants were recruited: 128 (42.7%) were diagnosed with no cognitive impairment (NCI), 47 (15.7%) with sd-MCI, and 83 (28.0%) with md-MCI. Forty-one participants were excluded, 7 (2.3%) had dementia, and 34 (11.3%) had only objective cognitive impairment without subjective complaints. Although the MoCA had a significantly larger AUC than the MMSE (0.94 (95% CI = 0.91-0.97) vs. 0.91 (95% CI = 0.86-0.95), p= 0.04), at optimal cut-off points, the MoCA (19/20) was equivalent to the MMSE (25/26) in detecting md-MCI (sensitivity: 0.80 vs. 0.87, specificity: 0.92 vs. 0.80).

CONCLUSION

Both screening tests had good discriminant validity and can be used in detecting md-MCI in a sub-sample of Chinese drawn from a population-based study.

Authors+Show Affiliations

Department of Pharmacology, National University of Singapore, Singapore.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23870281

Citation

Dong, YanHong, et al. "Comparison of the Montreal Cognitive Assessment and the Mini-Mental State Examination in Detecting Multi-domain Mild Cognitive Impairment in a Chinese Sub-sample Drawn From a Population-based Study." International Psychogeriatrics, vol. 25, no. 11, 2013, pp. 1831-8.
Dong Y, Yean Lee W, Hilal S, et al. Comparison of the Montreal Cognitive Assessment and the Mini-Mental State Examination in detecting multi-domain mild cognitive impairment in a Chinese sub-sample drawn from a population-based study. Int Psychogeriatr. 2013;25(11):1831-8.
Dong, Y., Yean Lee, W., Hilal, S., Saini, M., Wong, T. Y., Chen, C. L., Venketasubramanian, N., & Ikram, M. K. (2013). Comparison of the Montreal Cognitive Assessment and the Mini-Mental State Examination in detecting multi-domain mild cognitive impairment in a Chinese sub-sample drawn from a population-based study. International Psychogeriatrics, 25(11), 1831-8. https://doi.org/10.1017/S1041610213001129
Dong Y, et al. Comparison of the Montreal Cognitive Assessment and the Mini-Mental State Examination in Detecting Multi-domain Mild Cognitive Impairment in a Chinese Sub-sample Drawn From a Population-based Study. Int Psychogeriatr. 2013;25(11):1831-8. PubMed PMID: 23870281.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of the Montreal Cognitive Assessment and the Mini-Mental State Examination in detecting multi-domain mild cognitive impairment in a Chinese sub-sample drawn from a population-based study. AU - Dong,YanHong, AU - Yean Lee,Wah, AU - Hilal,Saima, AU - Saini,Monica, AU - Wong,Tien Yin, AU - Chen,Christopher Li-Hsian, AU - Venketasubramanian,Narayanaswamy, AU - Ikram,Mohammad Kamran, Y1 - 2013/07/22/ PY - 2013/7/23/entrez PY - 2013/7/23/pubmed PY - 2014/8/15/medline SP - 1831 EP - 8 JF - International psychogeriatrics JO - Int Psychogeriatr VL - 25 IS - 11 N2 - BACKGROUND: We examined the discriminant validity of the Montreal Cognitive Assessment (MoCA) and the Mini-Mental State Examination (MMSE) in detecting multiple-domain mild cognitive impairment (md-MCI) in a Chinese sub-sample drawn from elderly population-based study. METHODS: This study included Chinese participants from the Epidemiology of Dementia in Singapore (EDIS) study aged ≥ 60 years who underwent cognitive screening with the Abbreviated Mental Test and Progressive Forgetfulness Questionnaire. Screen-positive participants subsequently underwent MoCA, MMSE, and a comprehensive formal neuropsychological battery. MCI was defined by Petersen's criteria and further classified into single-domain MCI (sd-MCI) and md-MCI. Area under the receiver operating characteristic curve (AUC) with 95% confidence intervals (CIs) was computed for the MoCA and the MMSE in detecting md-MCI. RESULTS: A total of 300 participants were recruited: 128 (42.7%) were diagnosed with no cognitive impairment (NCI), 47 (15.7%) with sd-MCI, and 83 (28.0%) with md-MCI. Forty-one participants were excluded, 7 (2.3%) had dementia, and 34 (11.3%) had only objective cognitive impairment without subjective complaints. Although the MoCA had a significantly larger AUC than the MMSE (0.94 (95% CI = 0.91-0.97) vs. 0.91 (95% CI = 0.86-0.95), p= 0.04), at optimal cut-off points, the MoCA (19/20) was equivalent to the MMSE (25/26) in detecting md-MCI (sensitivity: 0.80 vs. 0.87, specificity: 0.92 vs. 0.80). CONCLUSION: Both screening tests had good discriminant validity and can be used in detecting md-MCI in a sub-sample of Chinese drawn from a population-based study. SN - 1741-203X UR - https://www.unboundmedicine.com/medline/citation/23870281/Comparison_of_the_Montreal_Cognitive_Assessment_and_the_Mini_Mental_State_Examination_in_detecting_multi_domain_mild_cognitive_impairment_in_a_Chinese_sub_sample_drawn_from_a_population_based_study_ L2 - https://www.cambridge.org/core/product/identifier/S1041610213001129/type/journal_article DB - PRIME DP - Unbound Medicine ER -