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Use of zinc protoporphyrin in screening individuals for exposure to lead.
Clin Chem. 1990 Aug; 36(8 Pt 1):1456-9.CC

Abstract

We studied the relation between the concentrations of lead in blood (PbB) and zinc protoporphyrin in blood (ZPP) in a group of 801 men occupationally exposed for more than one year to lead or inorganic lead compounds. Linear regression of PbB on log ZPP provided 95% tolerance intervals for PbB values for a given ZPP value. The intervals we found are too large to warrant the estimation of PbB on the basis of ZPP measurements in health surveillance of lead workers. Instead we propose a procedure in which ZPP can be used as an indicator to decide which individuals exposed to lead need further investigation of PbB in light of existing limit values for PbB. The procedure is applicable only for PbB values of 2.4 mumol/L or more but may reduce considerably the costs for screening individuals or groups of people exposed to lead.

Authors+Show Affiliations

Department of Occupational Toxicology, TNO Medical Biological Laboratory, Rijswijk, The Netherlands.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2387041

Citation

Zwennis, W C., et al. "Use of Zinc Protoporphyrin in Screening Individuals for Exposure to Lead." Clinical Chemistry, vol. 36, no. 8 Pt 1, 1990, pp. 1456-9.
Zwennis WC, Franssen AC, Wijnans MJ. Use of zinc protoporphyrin in screening individuals for exposure to lead. Clin Chem. 1990;36(8 Pt 1):1456-9.
Zwennis, W. C., Franssen, A. C., & Wijnans, M. J. (1990). Use of zinc protoporphyrin in screening individuals for exposure to lead. Clinical Chemistry, 36(8 Pt 1), 1456-9.
Zwennis WC, Franssen AC, Wijnans MJ. Use of Zinc Protoporphyrin in Screening Individuals for Exposure to Lead. Clin Chem. 1990;36(8 Pt 1):1456-9. PubMed PMID: 2387041.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of zinc protoporphyrin in screening individuals for exposure to lead. AU - Zwennis,W C, AU - Franssen,A C, AU - Wijnans,M J, PY - 1990/8/1/pubmed PY - 1990/8/1/medline PY - 1990/8/1/entrez SP - 1456 EP - 9 JF - Clinical chemistry JO - Clin Chem VL - 36 IS - 8 Pt 1 N2 - We studied the relation between the concentrations of lead in blood (PbB) and zinc protoporphyrin in blood (ZPP) in a group of 801 men occupationally exposed for more than one year to lead or inorganic lead compounds. Linear regression of PbB on log ZPP provided 95% tolerance intervals for PbB values for a given ZPP value. The intervals we found are too large to warrant the estimation of PbB on the basis of ZPP measurements in health surveillance of lead workers. Instead we propose a procedure in which ZPP can be used as an indicator to decide which individuals exposed to lead need further investigation of PbB in light of existing limit values for PbB. The procedure is applicable only for PbB values of 2.4 mumol/L or more but may reduce considerably the costs for screening individuals or groups of people exposed to lead. SN - 0009-9147 UR - https://www.unboundmedicine.com/medline/citation/2387041/Use_of_zinc_protoporphyrin_in_screening_individuals_for_exposure_to_lead_ DB - PRIME DP - Unbound Medicine ER -