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Protective role of Punica granatum (pomegranate) peel and seed oil extracts on diethylnitrosamine and phenobarbital-induced hepatic injury in male rats.
Food Chem. 2013 Dec 01; 141(3):1587-96.FC

Abstract

The present study is an attempt to reveal the protective role of Punica granatum peel and seed oil extracts against diethylnitrosamine (DEN) and phenobarbital (PB) induced hepatic injury in rats. DEN administration increased the levels of malondialdehyde (MDA), DNA fragmentation, caspase-3 and glutathione reductase (GSR) activities, while the level of reduced glutathione (GSH) and the activities of superoxide dismutase (SOD), glutathione S-transferase (GST) and total glutathione peroxidase (t-GPx) were decreased compared with the control. Treatment with peel and seed oil extracts pre, during and post DEN administration improved liver functions, decreased the levels of MDA, DNA fragmentation, caspase-3 and GSR activities with an elevation in levels of GSH, SOD, GST and t-GPx activities. This indicates that these extracts reduced the oxidative stress and apoptosis induced by DEN. Also the effect of administration of PE and SOE separately for a long time (23 weeks) on healthy rats was studied.

Authors+Show Affiliations

Biochemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt. nshaban2001@yahoo.co.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23870864

Citation

Shaban, Nadia Z., et al. "Protective Role of Punica Granatum (pomegranate) Peel and Seed Oil Extracts On Diethylnitrosamine and Phenobarbital-induced Hepatic Injury in Male Rats." Food Chemistry, vol. 141, no. 3, 2013, pp. 1587-96.
Shaban NZ, El-Kersh MA, El-Rashidy FH, et al. Protective role of Punica granatum (pomegranate) peel and seed oil extracts on diethylnitrosamine and phenobarbital-induced hepatic injury in male rats. Food Chem. 2013;141(3):1587-96.
Shaban, N. Z., El-Kersh, M. A., El-Rashidy, F. H., & Habashy, N. H. (2013). Protective role of Punica granatum (pomegranate) peel and seed oil extracts on diethylnitrosamine and phenobarbital-induced hepatic injury in male rats. Food Chemistry, 141(3), 1587-96. https://doi.org/10.1016/j.foodchem.2013.04.134
Shaban NZ, et al. Protective Role of Punica Granatum (pomegranate) Peel and Seed Oil Extracts On Diethylnitrosamine and Phenobarbital-induced Hepatic Injury in Male Rats. Food Chem. 2013 Dec 1;141(3):1587-96. PubMed PMID: 23870864.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective role of Punica granatum (pomegranate) peel and seed oil extracts on diethylnitrosamine and phenobarbital-induced hepatic injury in male rats. AU - Shaban,Nadia Z, AU - El-Kersh,Mohamed A L, AU - El-Rashidy,Fatma H, AU - Habashy,Noha H, Y1 - 2013/05/23/ PY - 2012/11/01/received PY - 2013/02/19/revised PY - 2013/04/30/accepted PY - 2013/7/23/entrez PY - 2013/7/23/pubmed PY - 2014/2/1/medline KW - Antioxidant KW - Apoptosis KW - Caspase-3 KW - DNA fragmentation KW - Diethylnitrosoamine KW - Hepatic injury KW - Lipid peroxidation KW - Pomegranate SP - 1587 EP - 96 JF - Food chemistry JO - Food Chem VL - 141 IS - 3 N2 - The present study is an attempt to reveal the protective role of Punica granatum peel and seed oil extracts against diethylnitrosamine (DEN) and phenobarbital (PB) induced hepatic injury in rats. DEN administration increased the levels of malondialdehyde (MDA), DNA fragmentation, caspase-3 and glutathione reductase (GSR) activities, while the level of reduced glutathione (GSH) and the activities of superoxide dismutase (SOD), glutathione S-transferase (GST) and total glutathione peroxidase (t-GPx) were decreased compared with the control. Treatment with peel and seed oil extracts pre, during and post DEN administration improved liver functions, decreased the levels of MDA, DNA fragmentation, caspase-3 and GSR activities with an elevation in levels of GSH, SOD, GST and t-GPx activities. This indicates that these extracts reduced the oxidative stress and apoptosis induced by DEN. Also the effect of administration of PE and SOE separately for a long time (23 weeks) on healthy rats was studied. SN - 1873-7072 UR - https://www.unboundmedicine.com/medline/citation/23870864/Protective_role_of_Punica_granatum__pomegranate__peel_and_seed_oil_extracts_on_diethylnitrosamine_and_phenobarbital_induced_hepatic_injury_in_male_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0308-8146(13)00676-6 DB - PRIME DP - Unbound Medicine ER -