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Reduced 25-hydroxyvitamin D and risk of Alzheimer's disease and vascular dementia.

Abstract

BACKGROUND

Vitamin D deficiency has been implicated as a risk factor for dementia in several cross-sectional studies. We tested the hypothesis that reduced plasma 25-hydroxyvitamin D (25[OH]D) is associated with increased risk of Alzheimer's disease (AD) and vascular dementia in the general population.

METHODS

We measured baseline plasma 25(OH)D in 10,186 white individuals from the Danish general population.

RESULTS

During 30 years of follow-up, 418 participants developed AD and 92 developed vascular dementia. Multivariable adjusted hazard ratios for AD were 1.25 (95% confidence interval [CI], 0.95-1.64) for 25(OH)D less than 25 nmol/L vs. greater than or equal to 50 nmol/L, and 1.29 (95% CI, 1.01-1.66) for less than the 25th seasonally adjusted 25(OH)D percentile vs. more than the 50th seasonally adjusted 25(OH)D percentile. Multivariable adjusted hazard ratios for vascular dementia were 1.22 (95% CI, 0.77-1.91) for 25(OH)D less than 50 nmol/L vs. greater than or equal to 50 nmol/L, and 1.22 (95% CI, 0.79-1.87) for less than or equal to the 50th vs. more than the 50th seasonally adjusted 25(OH)D percentile. Last, multivariable adjusted hazard ratios for the combined end point were 1.28 (95% CI, 1.00-1.64) for 25(OH)D less than 25 nmol/L vs. greater than or equal to 50 nmol/L, and 1.27 (95% CI, 1.01-1.60) for less than the 25th vs. more than the 50th seasonally adjusted 25(OH)D.

CONCLUSIONS

We observed an association of reduced plasma 25(OH)D with increased risk of the combined end point of AD and vascular dementia in this prospective cohort study of the general population.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    The Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark.

    ,

    The Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark; The Copenhagen City Heart Study, Bispebjerg Hospital, Copenhagen University Hospital, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Herlev, Denmark.

    The Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark; The Copenhagen City Heart Study, Bispebjerg Hospital, Copenhagen University Hospital, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Herlev, Denmark. Electronic address: Boerge.Nordestgaard@regionh.dk.

    Source

    MeSH

    Aged
    Alzheimer Disease
    Blood Chemical Analysis
    Dementia, Vascular
    Denmark
    Female
    Follow-Up Studies
    Humans
    Male
    Middle Aged
    Multivariate Analysis
    Proportional Hazards Models
    Prospective Studies
    Risk
    Risk Factors
    Vitamin D
    Vitamin D Deficiency

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    23871764

    Citation

    Afzal, Shoaib, et al. "Reduced 25-hydroxyvitamin D and Risk of Alzheimer's Disease and Vascular Dementia." Alzheimer's & Dementia : the Journal of the Alzheimer's Association, vol. 10, no. 3, 2014, pp. 296-302.
    Afzal S, Bojesen SE, Nordestgaard BG. Reduced 25-hydroxyvitamin D and risk of Alzheimer's disease and vascular dementia. Alzheimers Dement. 2014;10(3):296-302.
    Afzal, S., Bojesen, S. E., & Nordestgaard, B. G. (2014). Reduced 25-hydroxyvitamin D and risk of Alzheimer's disease and vascular dementia. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 10(3), pp. 296-302. doi:10.1016/j.jalz.2013.05.1765.
    Afzal S, Bojesen SE, Nordestgaard BG. Reduced 25-hydroxyvitamin D and Risk of Alzheimer's Disease and Vascular Dementia. Alzheimers Dement. 2014;10(3):296-302. PubMed PMID: 23871764.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Reduced 25-hydroxyvitamin D and risk of Alzheimer's disease and vascular dementia. AU - Afzal,Shoaib, AU - Bojesen,Stig E, AU - Nordestgaard,Børge G, Y1 - 2013/07/18/ PY - 2013/01/30/received PY - 2013/05/04/revised PY - 2013/05/08/accepted PY - 2013/7/23/entrez PY - 2013/7/23/pubmed PY - 2014/12/15/medline KW - Alzheimer’s disease KW - Cohort study KW - General population KW - Vascular dementia KW - Vitamin D SP - 296 EP - 302 JF - Alzheimer's & dementia : the journal of the Alzheimer's Association JO - Alzheimers Dement VL - 10 IS - 3 N2 - BACKGROUND: Vitamin D deficiency has been implicated as a risk factor for dementia in several cross-sectional studies. We tested the hypothesis that reduced plasma 25-hydroxyvitamin D (25[OH]D) is associated with increased risk of Alzheimer's disease (AD) and vascular dementia in the general population. METHODS: We measured baseline plasma 25(OH)D in 10,186 white individuals from the Danish general population. RESULTS: During 30 years of follow-up, 418 participants developed AD and 92 developed vascular dementia. Multivariable adjusted hazard ratios for AD were 1.25 (95% confidence interval [CI], 0.95-1.64) for 25(OH)D less than 25 nmol/L vs. greater than or equal to 50 nmol/L, and 1.29 (95% CI, 1.01-1.66) for less than the 25th seasonally adjusted 25(OH)D percentile vs. more than the 50th seasonally adjusted 25(OH)D percentile. Multivariable adjusted hazard ratios for vascular dementia were 1.22 (95% CI, 0.77-1.91) for 25(OH)D less than 50 nmol/L vs. greater than or equal to 50 nmol/L, and 1.22 (95% CI, 0.79-1.87) for less than or equal to the 50th vs. more than the 50th seasonally adjusted 25(OH)D percentile. Last, multivariable adjusted hazard ratios for the combined end point were 1.28 (95% CI, 1.00-1.64) for 25(OH)D less than 25 nmol/L vs. greater than or equal to 50 nmol/L, and 1.27 (95% CI, 1.01-1.60) for less than the 25th vs. more than the 50th seasonally adjusted 25(OH)D. CONCLUSIONS: We observed an association of reduced plasma 25(OH)D with increased risk of the combined end point of AD and vascular dementia in this prospective cohort study of the general population. SN - 1552-5279 UR - https://www.unboundmedicine.com/medline/citation/23871764/Reduced_25_hydroxyvitamin_D_and_risk_of_Alzheimer's_disease_and_vascular_dementia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1552-5260(13)02425-4 DB - PRIME DP - Unbound Medicine ER -