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Effects of habitual coffee consumption on cardiometabolic disease, cardiovascular health, and all-cause mortality.

Abstract

Coffee, after water, is the most widely consumed beverage in the United States, and is the principal source of caffeine intake among adults. The biological effects of coffee may be substantial and are not limited to the actions of caffeine. Coffee is a complex beverage containing hundreds of biologically active compounds, and the health effects of chronic coffee intake are wide ranging. From a cardiovascular (CV) standpoint, coffee consumption may reduce the risk of type 2 diabetes mellitus and hypertension, as well as other conditions associated with CV risk such as obesity and depression; but it may adversely affect lipid profiles depending on how the beverage is prepared. Regardless, a growing body of data suggests that habitual coffee consumption is neutral to beneficial regarding the risks of a variety of adverse CV outcomes including coronary heart disease, congestive heart failure, arrhythmias, and stroke. Moreover, large epidemiological studies suggest that regular coffee drinkers have reduced risks of mortality, both CV and all-cause. The potential benefits also include protection against neurodegenerative diseases, improved asthma control, and lower risk of select gastrointestinal diseases. A daily intake of ∼2 to 3 cups of coffee appears to be safe and is associated with neutral to beneficial effects for most of the studied health outcomes. However, most of the data on coffee's health effects are based on observational data, with very few randomized, controlled studies, and association does not prove causation. Additionally, the possible advantages of regular coffee consumption have to be weighed against potential risks (which are mostly related to its high caffeine content) including anxiety, insomnia, tremulousness, and palpitations, as well as bone loss and possibly increased risk of fractures.

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  • Authors+Show Affiliations

    ,

    Mid America Heart Institute at Saint Luke's Hospital of Kansas City and University of Missouri-Kansas City, Kansas City, Missouri. Electronic address: jokeefe@saint-lukes.org.

    ,

    Mid America Heart Institute at Saint Luke's Hospital of Kansas City and University of Missouri-Kansas City, Kansas City, Missouri.

    ,

    Mid America Heart Institute at Saint Luke's Hospital of Kansas City and University of Missouri-Kansas City, Kansas City, Missouri.

    ,

    Mid America Heart Institute at Saint Luke's Hospital of Kansas City and University of Missouri-Kansas City, Kansas City, Missouri.

    ,

    Department of Family and Social Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York.

    John Ochsner Heart and Vascular Institute, Ochsner Clinical School, The University of Queensland School of Medicine, New Orleans, Louisiana.

    Source

    Journal of the American College of Cardiology 62:12 2013 Sep 17 pg 1043-1051

    MeSH

    Animals
    Blood Pressure
    Cardiovascular Diseases
    Cardiovascular Physiological Phenomena
    Coffee
    Humans
    Insulin Resistance
    Lipids
    Mortality

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    23871889

    Citation

    O'Keefe, James H., et al. "Effects of Habitual Coffee Consumption On Cardiometabolic Disease, Cardiovascular Health, and All-cause Mortality." Journal of the American College of Cardiology, vol. 62, no. 12, 2013, pp. 1043-1051.
    O'Keefe JH, Bhatti SK, Patil HR, et al. Effects of habitual coffee consumption on cardiometabolic disease, cardiovascular health, and all-cause mortality. J Am Coll Cardiol. 2013;62(12):1043-1051.
    O'Keefe, J. H., Bhatti, S. K., Patil, H. R., DiNicolantonio, J. J., Lucan, S. C., & Lavie, C. J. (2013). Effects of habitual coffee consumption on cardiometabolic disease, cardiovascular health, and all-cause mortality. Journal of the American College of Cardiology, 62(12), pp. 1043-1051. doi:10.1016/j.jacc.2013.06.035.
    O'Keefe JH, et al. Effects of Habitual Coffee Consumption On Cardiometabolic Disease, Cardiovascular Health, and All-cause Mortality. J Am Coll Cardiol. 2013 Sep 17;62(12):1043-1051. PubMed PMID: 23871889.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effects of habitual coffee consumption on cardiometabolic disease, cardiovascular health, and all-cause mortality. AU - O'Keefe,James H, AU - Bhatti,Salman K, AU - Patil,Harshal R, AU - DiNicolantonio,James J, AU - Lucan,Sean C, AU - Lavie,Carl J, Y1 - 2013/07/17/ PY - 2013/05/08/received PY - 2013/06/09/revised PY - 2013/06/18/accepted PY - 2013/7/23/entrez PY - 2013/7/23/pubmed PY - 2013/11/14/medline KW - AF KW - BP KW - CHD KW - CHF KW - CI KW - CV KW - HTN KW - LDL KW - MI KW - RCT KW - RR KW - T2DM KW - atrial fibrillation KW - blood pressure KW - caffeine KW - cardiometabolic disease KW - cardiovascular KW - coffee KW - confidence interval KW - congestive heart failure KW - coronary heart disease KW - coronary heart disease KW - hypertension KW - low-density lipoprotein KW - myocardial infarction KW - randomized, controlled trial KW - relative risk KW - type 2 diabetes mellitus SP - 1043 EP - 1051 JF - Journal of the American College of Cardiology JO - J. Am. Coll. Cardiol. VL - 62 IS - 12 N2 - Coffee, after water, is the most widely consumed beverage in the United States, and is the principal source of caffeine intake among adults. The biological effects of coffee may be substantial and are not limited to the actions of caffeine. Coffee is a complex beverage containing hundreds of biologically active compounds, and the health effects of chronic coffee intake are wide ranging. From a cardiovascular (CV) standpoint, coffee consumption may reduce the risk of type 2 diabetes mellitus and hypertension, as well as other conditions associated with CV risk such as obesity and depression; but it may adversely affect lipid profiles depending on how the beverage is prepared. Regardless, a growing body of data suggests that habitual coffee consumption is neutral to beneficial regarding the risks of a variety of adverse CV outcomes including coronary heart disease, congestive heart failure, arrhythmias, and stroke. Moreover, large epidemiological studies suggest that regular coffee drinkers have reduced risks of mortality, both CV and all-cause. The potential benefits also include protection against neurodegenerative diseases, improved asthma control, and lower risk of select gastrointestinal diseases. A daily intake of ∼2 to 3 cups of coffee appears to be safe and is associated with neutral to beneficial effects for most of the studied health outcomes. However, most of the data on coffee's health effects are based on observational data, with very few randomized, controlled studies, and association does not prove causation. Additionally, the possible advantages of regular coffee consumption have to be weighed against potential risks (which are mostly related to its high caffeine content) including anxiety, insomnia, tremulousness, and palpitations, as well as bone loss and possibly increased risk of fractures. SN - 1558-3597 UR - https://www.unboundmedicine.com/medline/citation/23871889/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735-1097(13)02601-6 DB - PRIME DP - Unbound Medicine ER -