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The role of α₂ adrenoceptor in mediating noradrenaline action in the ventrolateral orbital cortex on allodynia following spared nerve injury.
Exp Neurol. 2013 Oct; 248:381-6.EN

Abstract

The present study examined the role of α₂ adrenoceptor in mediating noradrenaline action in the ventrolateral orbital cortex (VLO) on allodynia induced by spared nerve injury (SNI) in the rat. The mechanical paw withdrawal threshold (PWT) was measured using von-Frey filaments. Microinjection of noradrenaline (1, 2, 4 μg in 0.5 μl) into the VLO, contralateral to the site of nerve injury, reduced allodynia; PWT increased in a dose-dependent manner. Similar to noradrenaline, microinjection of selective α₂ adrenoceptor agonist clonidine into the same VLO site also reduced allodynia, and was blocked by selective α₂ adrenoceptor antagonist yohimbine. Furthermore, administration of γ-aminobutyric acid A (GABAA) receptor antagonist bicuculline or picrotoxin to the VLO significantly enhanced clonidine-induced inhibition of allodynia, while GABAA receptor agonist muscimol or THIP (2,5,6,7-retrahydroisoxazolo(5,4-c)pyridine-3-ol hydrochloride) attenuated clonidine-induced inhibition. These results suggest that noradrenaline acting in the VLO can potentially reduce allodynia induced by SNI, and this effect is mediated by α₂ adrenoceptor. Moreover, GABAergic disinhibition may participate in α₂ receptor mediating effects in neuropathic pain in the central nervous system.

Authors+Show Affiliations

Department of Physiology and Pathophysiology, Xi'an Jiaotong University College of Medicine, Yanta Road W. 76#, Xi'an, Shaanxi 710061, PR China; Department of Physiology, Xi'an Medical University, Xinwang Road 1#, Xi'an, Shaanxi 710021, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23872512

Citation

Zhu, Juan-Xia, et al. "The Role of Α₂ Adrenoceptor in Mediating Noradrenaline Action in the Ventrolateral Orbital Cortex On Allodynia Following Spared Nerve Injury." Experimental Neurology, vol. 248, 2013, pp. 381-6.
Zhu JX, Xu FY, Xu WJ, et al. The role of α₂ adrenoceptor in mediating noradrenaline action in the ventrolateral orbital cortex on allodynia following spared nerve injury. Exp Neurol. 2013;248:381-6.
Zhu, J. X., Xu, F. Y., Xu, W. J., Zhao, Y., Qu, C. L., Tang, J. S., Barry, D. M., Du, J. Q., & Huo, F. Q. (2013). The role of α₂ adrenoceptor in mediating noradrenaline action in the ventrolateral orbital cortex on allodynia following spared nerve injury. Experimental Neurology, 248, 381-6. https://doi.org/10.1016/j.expneurol.2013.07.004
Zhu JX, et al. The Role of Α₂ Adrenoceptor in Mediating Noradrenaline Action in the Ventrolateral Orbital Cortex On Allodynia Following Spared Nerve Injury. Exp Neurol. 2013;248:381-6. PubMed PMID: 23872512.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of α₂ adrenoceptor in mediating noradrenaline action in the ventrolateral orbital cortex on allodynia following spared nerve injury. AU - Zhu,Juan-Xia, AU - Xu,Feng-Yi, AU - Xu,Wen-Jin, AU - Zhao,Yan, AU - Qu,Chao-Ling, AU - Tang,Jing-Shi, AU - Barry,Devin M, AU - Du,Jian-Qing, AU - Huo,Fu-Quan, Y1 - 2013/07/18/ PY - 2013/05/24/received PY - 2013/07/05/revised PY - 2013/07/11/accepted PY - 2013/7/23/entrez PY - 2013/7/23/pubmed PY - 2013/12/16/medline KW - (+)-bicuculline, (S), 9(R) KW - 2,5,6,7-retrahydroisoxazolo(5,4-c)pyridine-3-ol hydrochloride KW - Allodynia KW - Bicuculline KW - Clonidine KW - GABA KW - GABAergic modulation KW - L-(−)-norepinephrine (+)-bitartrate salt monohydrate KW - Muscimol KW - Neuropathic pain KW - Noradrenaline KW - PAG KW - PWT KW - SNI KW - Sm KW - THIP KW - VLO KW - Ventrolateral orbital cortex KW - Yohimbine KW - clonidine hydrochloride KW - muscimol hydrochloride KW - nucleus submedius KW - paw withdrawal threshold KW - periaqueductal gray KW - spared nerve injury KW - ventrolateral orbital cortex KW - yohimbine hydrochloride KW - α(2) adrenoceptor KW - γ-aminobutyric acid SP - 381 EP - 6 JF - Experimental neurology JO - Exp Neurol VL - 248 N2 - The present study examined the role of α₂ adrenoceptor in mediating noradrenaline action in the ventrolateral orbital cortex (VLO) on allodynia induced by spared nerve injury (SNI) in the rat. The mechanical paw withdrawal threshold (PWT) was measured using von-Frey filaments. Microinjection of noradrenaline (1, 2, 4 μg in 0.5 μl) into the VLO, contralateral to the site of nerve injury, reduced allodynia; PWT increased in a dose-dependent manner. Similar to noradrenaline, microinjection of selective α₂ adrenoceptor agonist clonidine into the same VLO site also reduced allodynia, and was blocked by selective α₂ adrenoceptor antagonist yohimbine. Furthermore, administration of γ-aminobutyric acid A (GABAA) receptor antagonist bicuculline or picrotoxin to the VLO significantly enhanced clonidine-induced inhibition of allodynia, while GABAA receptor agonist muscimol or THIP (2,5,6,7-retrahydroisoxazolo(5,4-c)pyridine-3-ol hydrochloride) attenuated clonidine-induced inhibition. These results suggest that noradrenaline acting in the VLO can potentially reduce allodynia induced by SNI, and this effect is mediated by α₂ adrenoceptor. Moreover, GABAergic disinhibition may participate in α₂ receptor mediating effects in neuropathic pain in the central nervous system. SN - 1090-2430 UR - https://www.unboundmedicine.com/medline/citation/23872512/The_role_of_α₂_adrenoceptor_in_mediating_noradrenaline_action_in_the_ventrolateral_orbital_cortex_on_allodynia_following_spared_nerve_injury_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-4886(13)00214-8 DB - PRIME DP - Unbound Medicine ER -