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Riboflavin/UVA photochemical therapy for severe infectious keratitis.
Eur J Ophthalmol. 2014 Jan-Feb; 24(1):21-8.EJ

Abstract

PURPOSE

To describe the antibacterial activity of treatment with riboflavin and ultraviolet A light (UVA) in cases of severe infectious keratitis.

METHODS

A retrospective analysis was performed of an interventional case series in which 6 eyes of 6 patients with severe infectious keratitis, all of whom were refractive to multidrug conventional therapy, were treated with riboflavin/UVA. The procedure was conducted according to the standardized protocol of corneal collagen crosslinking (CXL) for keratoconus. Best spectacle-corrected visual acuity and clinical outcomes were evaluated before and during the follow-up period.

RESULTS

Five of the 6 patients showed rapid reduction in symptoms and decreased infiltrate size after riboflavin/UVA photochemical therapy. Signs of infection and inflammation mostly resolved within 1 to 2 weeks after the treatment. Despite this therapy, one patient continued to deteriorate, and penetrating keratoplasty was performed.

CONCLUSIONS

The adjunctive use of riboflavin/UVA photochemical therapy has a positive effect on refractory infectious keratitis. The treatment seems to be safe and effective and should be considered as part of the first-line therapy in severe cases of infectious keratitis.

Authors+Show Affiliations

2 Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv - Israel.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

23873492

Citation

Skaat, Alon, et al. "Riboflavin/UVA Photochemical Therapy for Severe Infectious Keratitis." European Journal of Ophthalmology, vol. 24, no. 1, 2014, pp. 21-8.
Skaat A, Zadok D, Goldich Y, et al. Riboflavin/UVA photochemical therapy for severe infectious keratitis. Eur J Ophthalmol. 2014;24(1):21-8.
Skaat, A., Zadok, D., Goldich, Y., Varssano, D., Berger, Y., Ezra-Nimni, O., Avni, I., & Barequet, I. S. (2014). Riboflavin/UVA photochemical therapy for severe infectious keratitis. European Journal of Ophthalmology, 24(1), 21-8. https://doi.org/10.5301/ejo.5000330
Skaat A, et al. Riboflavin/UVA Photochemical Therapy for Severe Infectious Keratitis. Eur J Ophthalmol. 2014 Jan-Feb;24(1):21-8. PubMed PMID: 23873492.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Riboflavin/UVA photochemical therapy for severe infectious keratitis. AU - Skaat,Alon, AU - Zadok,David, AU - Goldich,Yakov, AU - Varssano,David, AU - Berger,Yoav, AU - Ezra-Nimni,Orit, AU - Avni,Isaac, AU - Barequet,Irina S, Y1 - 2013/07/17/ PY - 2013/05/23/accepted PY - 2013/7/23/entrez PY - 2013/7/23/pubmed PY - 2014/2/8/medline SP - 21 EP - 8 JF - European journal of ophthalmology JO - Eur J Ophthalmol VL - 24 IS - 1 N2 - PURPOSE: To describe the antibacterial activity of treatment with riboflavin and ultraviolet A light (UVA) in cases of severe infectious keratitis. METHODS: A retrospective analysis was performed of an interventional case series in which 6 eyes of 6 patients with severe infectious keratitis, all of whom were refractive to multidrug conventional therapy, were treated with riboflavin/UVA. The procedure was conducted according to the standardized protocol of corneal collagen crosslinking (CXL) for keratoconus. Best spectacle-corrected visual acuity and clinical outcomes were evaluated before and during the follow-up period. RESULTS: Five of the 6 patients showed rapid reduction in symptoms and decreased infiltrate size after riboflavin/UVA photochemical therapy. Signs of infection and inflammation mostly resolved within 1 to 2 weeks after the treatment. Despite this therapy, one patient continued to deteriorate, and penetrating keratoplasty was performed. CONCLUSIONS: The adjunctive use of riboflavin/UVA photochemical therapy has a positive effect on refractory infectious keratitis. The treatment seems to be safe and effective and should be considered as part of the first-line therapy in severe cases of infectious keratitis. SN - 1724-6016 UR - https://www.unboundmedicine.com/medline/citation/23873492/Riboflavin/UVA_photochemical_therapy_for_severe_infectious_keratitis_ L2 - https://journals.sagepub.com/doi/10.5301/ejo.5000330?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -