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Dopaminergic activity in Tourette syndrome and obsessive-compulsive disorder.
Eur Neuropsychopharmacol. 2013 Nov; 23(11):1423-31.EN

Abstract

Tourette syndrome (TS) and obsessive-compulsive disorder (OCD) both are neuropsychiatric disorders associated with abnormalities in dopamine neurotransmission. Aims of this study were to quantify striatal D2/3 receptor availability in TS and OCD, and to examine dopamine release and symptom severity changes in both disorders following amphetamine challenge. Changes in [(11)C]raclopride binding potential (BP(ND)) were assessed using positron emission tomography before and after administration of d-amphetamine (0.3 mg kg(-1)) in 12 TS patients without comorbid OCD, 12 OCD patients without comorbid tics, and 12 healthy controls. Main outcome measures were baseline striatal D2/3 receptor BP(ND) and change in BP(ND) following amphetamine as a measure of dopamine release. Voxel-based analysis revealed significantly decreased baseline [(11)C]raclopride BP(ND) in bilateral putamen of both patient groups vs. healthy controls, differences being more pronounced in the TS than in the OCD group. Changes in BP(ND) following amphetamine were not significantly different between groups. Following amphetamine administration, tic severity increased in the TS group, which correlated with BP(ND) changes in right ventral striatum. Symptom severity in the OCD group did not change significantly following amphetamine challenge and was not associated with changes in BP(ND). This study provides evidence for decreased striatal D2/3 receptor availability in TS and OCD, presumably reflecting higher endogenous dopamine levels in both disorders. In addition, it provides the first direct evidence that ventral striatal dopamine release is related to the pathophysiology of tics.

Authors+Show Affiliations

Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; The Netherlands Institute for Neuroscience, An Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands. Electronic address: ddenys@gmail.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23876376

Citation

Denys, Damiaan, et al. "Dopaminergic Activity in Tourette Syndrome and Obsessive-compulsive Disorder." European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, vol. 23, no. 11, 2013, pp. 1423-31.
Denys D, de Vries F, Cath D, et al. Dopaminergic activity in Tourette syndrome and obsessive-compulsive disorder. Eur Neuropsychopharmacol. 2013;23(11):1423-31.
Denys, D., de Vries, F., Cath, D., Figee, M., Vulink, N., Veltman, D. J., van der Doef, T. F., Boellaard, R., Westenberg, H., van Balkom, A., Lammertsma, A. A., & van Berckel, B. N. (2013). Dopaminergic activity in Tourette syndrome and obsessive-compulsive disorder. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, 23(11), 1423-31. https://doi.org/10.1016/j.euroneuro.2013.05.012
Denys D, et al. Dopaminergic Activity in Tourette Syndrome and Obsessive-compulsive Disorder. Eur Neuropsychopharmacol. 2013;23(11):1423-31. PubMed PMID: 23876376.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dopaminergic activity in Tourette syndrome and obsessive-compulsive disorder. AU - Denys,Damiaan, AU - de Vries,Froukje, AU - Cath,Danielle, AU - Figee,Martijn, AU - Vulink,Nienke, AU - Veltman,Dick J, AU - van der Doef,Thalia F, AU - Boellaard,Ronald, AU - Westenberg,Herman, AU - van Balkom,Anton, AU - Lammertsma,Adriaan A, AU - van Berckel,Bart N M, Y1 - 2013/07/19/ PY - 2013/01/24/received PY - 2013/05/22/revised PY - 2013/05/24/accepted PY - 2013/7/24/entrez PY - 2013/7/24/pubmed PY - 2014/6/18/medline KW - Amphetamine KW - Dopamine KW - Obsessive-compulsive disorder KW - Positron emission tomography KW - Tourette syndrome KW - [(11)C]raclopride SP - 1423 EP - 31 JF - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology JO - Eur Neuropsychopharmacol VL - 23 IS - 11 N2 - Tourette syndrome (TS) and obsessive-compulsive disorder (OCD) both are neuropsychiatric disorders associated with abnormalities in dopamine neurotransmission. Aims of this study were to quantify striatal D2/3 receptor availability in TS and OCD, and to examine dopamine release and symptom severity changes in both disorders following amphetamine challenge. Changes in [(11)C]raclopride binding potential (BP(ND)) were assessed using positron emission tomography before and after administration of d-amphetamine (0.3 mg kg(-1)) in 12 TS patients without comorbid OCD, 12 OCD patients without comorbid tics, and 12 healthy controls. Main outcome measures were baseline striatal D2/3 receptor BP(ND) and change in BP(ND) following amphetamine as a measure of dopamine release. Voxel-based analysis revealed significantly decreased baseline [(11)C]raclopride BP(ND) in bilateral putamen of both patient groups vs. healthy controls, differences being more pronounced in the TS than in the OCD group. Changes in BP(ND) following amphetamine were not significantly different between groups. Following amphetamine administration, tic severity increased in the TS group, which correlated with BP(ND) changes in right ventral striatum. Symptom severity in the OCD group did not change significantly following amphetamine challenge and was not associated with changes in BP(ND). This study provides evidence for decreased striatal D2/3 receptor availability in TS and OCD, presumably reflecting higher endogenous dopamine levels in both disorders. In addition, it provides the first direct evidence that ventral striatal dopamine release is related to the pathophysiology of tics. SN - 1873-7862 UR - https://www.unboundmedicine.com/medline/citation/23876376/Dopaminergic_activity_in_Tourette_syndrome_and_obsessive_compulsive_disorder_ DB - PRIME DP - Unbound Medicine ER -