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CMV amplifies T-cell redeployment to acute exercise independently of HSV-1 serostatus.
Med Sci Sports Exerc. 2014 Feb; 46(2):257-67.MS

Abstract

PURPOSE

Latent cytomegalovirus (CMV) infection has been shown to alter the lymphocyte response to acute aerobic exercise, likely due to the corresponding increase in exercise-responsive memory CD8(+) T cells. It is unknown if latent infection with another herpesvirus, herpes simplex virus 1 (HSV-1), also plays a role in shaping the lymphocyte response to exercise.

METHODS

Thirty-two men (ages 39.3 ± 14.7 yr) counterbalanced by CMV and HSV-1 serostatus (positive/negative) cycled for 30 min at ∼80% peak power. Blood sampled before, immediately after, and 1 h after exercise was analyzed by flow cytometry for T-cell subset enumeration.

RESULTS

In resting blood, HSV-1(+) had fewer lymphocytes, CD4(+) T cells, KLRG1(-) CD28(+) CD4(+) T cells, and CD45RA(-)CCR7(+)CD4(+) T cells than HSV-1(-), whereas CMV(+) had increased numbers of lymphocytes, CD8(+) T cells, KLRG1(+)CD28(-)CD4(+) and CD8(+) T cells, and CD45RA(+)CCR7(-)CD8(+) T cells and a lower CD4:CD8 T-cell ratio than CMV(-). After exercise, CMV(+) had a greater mobilization of CD8(+) T cells, KLRG1+CD28(-)CD4+ and CD8(+) T cells, and CD45RA+CCR7(-)CD8+ T cells independently of HSV-1 serostatus, as well as a greater egress of these subsets 1 h after exercise. HSV serostatus did not influence total CD8(+) T-cell response to exercise.

CONCLUSIONS

The impact of latent CMV infection on the redeployment of T-cell subsets with exercise is independent of HSV-1 infection. This is most likely due to the unique ability of CMV to alter the composition of the memory T-cell pool in favor of exercise-responsive T-cell subsets.

Authors+Show Affiliations

Laboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, Houston, TX.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

23877375

Citation

Lavoy, Emily C., et al. "CMV Amplifies T-cell Redeployment to Acute Exercise Independently of HSV-1 Serostatus." Medicine and Science in Sports and Exercise, vol. 46, no. 2, 2014, pp. 257-67.
Lavoy EC, Bigley AB, Spielmann G, et al. CMV amplifies T-cell redeployment to acute exercise independently of HSV-1 serostatus. Med Sci Sports Exerc. 2014;46(2):257-67.
Lavoy, E. C., Bigley, A. B., Spielmann, G., Rector, J. L., Morrison, M. R., O'Connor, D. P., & Simpson, R. J. (2014). CMV amplifies T-cell redeployment to acute exercise independently of HSV-1 serostatus. Medicine and Science in Sports and Exercise, 46(2), 257-67. https://doi.org/10.1249/MSS.0b013e3182a5a0fb
Lavoy EC, et al. CMV Amplifies T-cell Redeployment to Acute Exercise Independently of HSV-1 Serostatus. Med Sci Sports Exerc. 2014;46(2):257-67. PubMed PMID: 23877375.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CMV amplifies T-cell redeployment to acute exercise independently of HSV-1 serostatus. AU - Lavoy,Emily C, AU - Bigley,Austin B, AU - Spielmann,Guillaume, AU - Rector,Jerrald L, AU - Morrison,Mark R, AU - O'Connor,Daniel P, AU - Simpson,Richard J, PY - 2013/7/24/entrez PY - 2013/7/24/pubmed PY - 2017/1/11/medline SP - 257 EP - 67 JF - Medicine and science in sports and exercise JO - Med Sci Sports Exerc VL - 46 IS - 2 N2 - PURPOSE: Latent cytomegalovirus (CMV) infection has been shown to alter the lymphocyte response to acute aerobic exercise, likely due to the corresponding increase in exercise-responsive memory CD8(+) T cells. It is unknown if latent infection with another herpesvirus, herpes simplex virus 1 (HSV-1), also plays a role in shaping the lymphocyte response to exercise. METHODS: Thirty-two men (ages 39.3 ± 14.7 yr) counterbalanced by CMV and HSV-1 serostatus (positive/negative) cycled for 30 min at ∼80% peak power. Blood sampled before, immediately after, and 1 h after exercise was analyzed by flow cytometry for T-cell subset enumeration. RESULTS: In resting blood, HSV-1(+) had fewer lymphocytes, CD4(+) T cells, KLRG1(-) CD28(+) CD4(+) T cells, and CD45RA(-)CCR7(+)CD4(+) T cells than HSV-1(-), whereas CMV(+) had increased numbers of lymphocytes, CD8(+) T cells, KLRG1(+)CD28(-)CD4(+) and CD8(+) T cells, and CD45RA(+)CCR7(-)CD8(+) T cells and a lower CD4:CD8 T-cell ratio than CMV(-). After exercise, CMV(+) had a greater mobilization of CD8(+) T cells, KLRG1+CD28(-)CD4+ and CD8(+) T cells, and CD45RA+CCR7(-)CD8+ T cells independently of HSV-1 serostatus, as well as a greater egress of these subsets 1 h after exercise. HSV serostatus did not influence total CD8(+) T-cell response to exercise. CONCLUSIONS: The impact of latent CMV infection on the redeployment of T-cell subsets with exercise is independent of HSV-1 infection. This is most likely due to the unique ability of CMV to alter the composition of the memory T-cell pool in favor of exercise-responsive T-cell subsets. SN - 1530-0315 UR - https://www.unboundmedicine.com/medline/citation/23877375/CMV_amplifies_T_cell_redeployment_to_acute_exercise_independently_of_HSV_1_serostatus_ L2 - https://doi.org/10.1249/MSS.0b013e3182a5a0fb DB - PRIME DP - Unbound Medicine ER -